CYP2E1 induction leads to oxidative stress and cytotoxicity in glutathione-depleted cerebellar granule neurons

•CYP2E1 is expressed in cerebellar granule cultured neurons.•Brain CYP2E1 induction leads to ROS generation.•CYP2E1 induction results in oxidative damage in glutathione-depleted neurons.•Oxidative damage can be inhibited by the addition of CYP2E1 inhibitor or antioxidant. Increasing evidence suggest...

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