Anti-tumor activity of human IgG1 anti-gp75 TA99 mAb against B16F10 melanoma in human FcgammaRI transgenic mice

Highlights • Human IgG1 anti-gp75 TA99 mAb shows normal target binding and functional in in vitro ADCC. • Human IgG1 TA99 mAb does not prevent outgrowth of B16F10 melanoma in wild type mice. • Anti-tumor effects of human IgG1 TA99 mAb against B16F10 melanoma in human FcgammaRI transgenic mice and Fc...

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Veröffentlicht in:	Immunology letters 2014-08, Vol.160 (2), p.151-157
Hauptverfasser:	Boross, Peter, Jansen, J.H. Marco, van Tetering, Geert, Nederend, Maaike, Brandsma, Arianne, Meyer, Saskia, Torfs, Ellen, van den Ham, Henk-Jan, Meulenbroek, Laura, de Haij, Simone, Leusen, Jeanette H.W
Format:	Artikel
Sprache:	eng
Schlagworte:	Allergy and Immunology Amino Acid Sequence Animals Antibodies, Monoclonal - chemistry Antibodies, Monoclonal - genetics Antibodies, Monoclonal - pharmacology Antibody therapy Cross Reactions Fc receptor gp75 Humans Hybridomas - chemistry Hybridomas - immunology Immunoglobulin G - chemistry Immunoglobulin G - genetics Immunoglobulin G - pharmacology Melanoma Melanoma, Experimental - immunology Melanoma, Experimental - pathology Melanoma, Experimental - therapy Membrane Glycoproteins - antagonists & inhibitors Membrane Glycoproteins - genetics Membrane Glycoproteins - immunology Mice Mice, Transgenic Molecular Sequence Data Oxidoreductases - antagonists & inhibitors Oxidoreductases - genetics Oxidoreductases - immunology Receptors, IgG - deficiency Receptors, IgG - genetics Receptors, IgG - immunology Recombinant Fusion Proteins - chemistry Recombinant Fusion Proteins - genetics Recombinant Fusion Proteins - pharmacology Skin Neoplasms - immunology Skin Neoplasms - pathology Skin Neoplasms - therapy TA99 Transgenes
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Beschreibung
Zusammenfassung:	Highlights • Human IgG1 anti-gp75 TA99 mAb shows normal target binding and functional in in vitro ADCC. • Human IgG1 TA99 mAb does not prevent outgrowth of B16F10 melanoma in wild type mice. • Anti-tumor effects of human IgG1 TA99 mAb against B16F10 melanoma in human FcgammaRI transgenic mice and FcgRIIB knockout mice.
ISSN:	0165-2478 1879-0542 1879-0542
DOI:	10.1016/j.imlet.2014.02.005