Disturbed Hsp70 and Hsp27 expression and thiol redox status in porcine kidney PK15 cells provoked by individual and combined ochratoxin A and citrinin treatments

•OTA and CTN exert cytotoxic synergism in porcine kidney PK15 cells.•Single and combined toxins decreased total thiols and GSH/GSSG ratio.•Hsp70 and Hsp27 were differentially affected by single and dual mycotoxin treatment.•OTA and CTN synergistically affect Hsps and redox homeostasis. The aim of th...

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Veröffentlicht in:	Food and chemical toxicology 2014-09, Vol.71, p.97-105
Hauptverfasser:	Šegvić Klarić, Maja, Medić, Nevena, Hulina, Andrea, Žanić Grubišić, Tihana, Rumora, Lada
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibacterial agents Antibiotics. Antiinfectious agents. Antiparasitic agents Biological and medical sciences Cell Line Citrinin Citrinin - toxicity Food toxicology Glutathione Glutathione - metabolism Heat shock proteins HSP27 Heat-Shock Proteins - metabolism HSP70 Heat-Shock Proteins - metabolism Kidney - cytology Kidney - drug effects Kidney - metabolism Medical sciences Ochratoxin A Ochratoxins - toxicity Oxidation-Reduction Oxidative stress Pharmacology. Drug treatments PK15 cells Plant poisons toxicology Sulfhydryl Compounds - metabolism Toxicology
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