Synergistic effect of quercetin and quinic acid by alleviating structural degeneration in the liver, kidney and pancreas tissues of STZ-induced diabetic rats: A mechanistic study
•The present study was to investigate the synergistic effects of QE and QA on STZ-induced diabetic rats.•Combination dose of QE and QA prevents the hyperglycaemia, oxidative stress and lipid accumulation in diabetic rats.•QE and QA treatment also inhibited the Bax expression and increased the Bcl-2...
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| creator | Arya, Aditya Jamil Al-Obaidi, Mazen M Shahid, Nayiar Bin Noordin, Mohamed Ibrahim Looi, Chung Yeng Wong, Won Fen Khaing, Si Lay Mustafa, Mohd Rais |
| description | •The present study was to investigate the synergistic effects of QE and QA on STZ-induced diabetic rats.•Combination dose of QE and QA prevents the hyperglycaemia, oxidative stress and lipid accumulation in diabetic rats.•QE and QA treatment also inhibited the Bax expression and increased the Bcl-2 expression in kidney cells.•Histological studies also revealed the protective role QE and QA in diabetic rats.•Our findings open a new window of research on the combinatorial therapy of flavonoids.
The aim of this study was to investigate the synergistic effects of quercetin (QE) and quinic acid (QA) on a STZ-induced diabetic rat model to determine their potential role in alleviating diabetes and its associated complications. In our study design, diabetic rats were treated with single and combined doses of QE and QA for 45days to analyse their effects on liver, kidney and pancreas tissues. The study result showed that QE and QA treated groups down-regulated hyperglycaemia and oxidative stress by up-regulating insulin and C-peptide levels. Moreover, histological observations of the liver, kidney and pancreas of diabetic rats treated with single and combined doses of QE and QA showed a significant improvement in the structural degeneration. Interestingly, the combination dose of QE and QA (50mg/kg) exhibited maximum inhibition of the pro-apoptotic protein Bax expression and demonstrate enhancement of the anti-apoptotic protein Bcl-2 expression in the kidney tissues, suggesting a protective role in the kidneys of diabetic rats. Taken together, these results indicates the synergistic effects of QE and QA in ameliorating hyperglycaemia, hyperlipidemia and insulin resistance in diabetic rats and therefore, open a new window of research on the combinatorial therapy of flavonoids. |
| doi_str_mv | 10.1016/j.fct.2014.06.010 |
| format | Article |
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The aim of this study was to investigate the synergistic effects of quercetin (QE) and quinic acid (QA) on a STZ-induced diabetic rat model to determine their potential role in alleviating diabetes and its associated complications. In our study design, diabetic rats were treated with single and combined doses of QE and QA for 45days to analyse their effects on liver, kidney and pancreas tissues. The study result showed that QE and QA treated groups down-regulated hyperglycaemia and oxidative stress by up-regulating insulin and C-peptide levels. Moreover, histological observations of the liver, kidney and pancreas of diabetic rats treated with single and combined doses of QE and QA showed a significant improvement in the structural degeneration. Interestingly, the combination dose of QE and QA (50mg/kg) exhibited maximum inhibition of the pro-apoptotic protein Bax expression and demonstrate enhancement of the anti-apoptotic protein Bcl-2 expression in the kidney tissues, suggesting a protective role in the kidneys of diabetic rats. Taken together, these results indicates the synergistic effects of QE and QA in ameliorating hyperglycaemia, hyperlipidemia and insulin resistance in diabetic rats and therefore, open a new window of research on the combinatorial therapy of flavonoids.</description><identifier>ISSN: 0278-6915</identifier><identifier>EISSN: 1873-6351</identifier><identifier>DOI: 10.1016/j.fct.2014.06.010</identifier><identifier>PMID: 24953551</identifier><identifier>CODEN: FCTOD7</identifier><language>eng</language><publisher>Oxford: Elsevier Ltd</publisher><subject>Animals ; Antibacterial agents ; Antibiotics. Antiinfectious agents. Antiparasitic agents ; Antineoplastic agents ; Antioxidants - metabolism ; Biological and medical sciences ; Chemotherapy ; Diabetes mellitus ; Diabetes. Impaired glucose tolerance ; Drug Synergism ; Endocrine pancreas. Apud cells (diseases) ; Endocrinopathies ; Enzymes - blood ; Etiopathogenesis. Screening. Investigations. Target tissue resistance ; Food toxicology ; Kidney - drug effects ; Kidney - pathology ; Liver - drug effects ; Liver - pathology ; Male ; Malondialdehyde - metabolism ; Medical sciences ; Pancreas - drug effects ; Pancreas - pathology ; Pharmacology. Drug treatments ; Quercetin ; Quercetin - pharmacology ; Quinic acid ; Quinic Acid - pharmacology ; Rats ; Rats, Sprague-Dawley ; Streptozocin ; Streptozotocin ; Synergistic effect ; Toxicology</subject><ispartof>Food and chemical toxicology, 2014-09, Vol.71, p.183-196</ispartof><rights>2014 Elsevier Ltd</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2014 Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c482t-fd953cb2ebe4e5fe3f3889b69865f61c38a8e10b53ecad38ab331a0778a8d263</citedby><cites>FETCH-LOGICAL-c482t-fd953cb2ebe4e5fe3f3889b69865f61c38a8e10b53ecad38ab331a0778a8d263</cites><orcidid>0000-0003-0296-9037</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0278691514002853$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27903,27904,65309</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=28688656$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24953551$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Arya, Aditya</creatorcontrib><creatorcontrib>Jamil Al-Obaidi, Mazen M</creatorcontrib><creatorcontrib>Shahid, Nayiar</creatorcontrib><creatorcontrib>Bin Noordin, Mohamed Ibrahim</creatorcontrib><creatorcontrib>Looi, Chung Yeng</creatorcontrib><creatorcontrib>Wong, Won Fen</creatorcontrib><creatorcontrib>Khaing, Si Lay</creatorcontrib><creatorcontrib>Mustafa, Mohd Rais</creatorcontrib><title>Synergistic effect of quercetin and quinic acid by alleviating structural degeneration in the liver, kidney and pancreas tissues of STZ-induced diabetic rats: A mechanistic study</title><title>Food and chemical toxicology</title><addtitle>Food Chem Toxicol</addtitle><description>•The present study was to investigate the synergistic effects of QE and QA on STZ-induced diabetic rats.•Combination dose of QE and QA prevents the hyperglycaemia, oxidative stress and lipid accumulation in diabetic rats.•QE and QA treatment also inhibited the Bax expression and increased the Bcl-2 expression in kidney cells.•Histological studies also revealed the protective role QE and QA in diabetic rats.•Our findings open a new window of research on the combinatorial therapy of flavonoids.
The aim of this study was to investigate the synergistic effects of quercetin (QE) and quinic acid (QA) on a STZ-induced diabetic rat model to determine their potential role in alleviating diabetes and its associated complications. In our study design, diabetic rats were treated with single and combined doses of QE and QA for 45days to analyse their effects on liver, kidney and pancreas tissues. The study result showed that QE and QA treated groups down-regulated hyperglycaemia and oxidative stress by up-regulating insulin and C-peptide levels. Moreover, histological observations of the liver, kidney and pancreas of diabetic rats treated with single and combined doses of QE and QA showed a significant improvement in the structural degeneration. Interestingly, the combination dose of QE and QA (50mg/kg) exhibited maximum inhibition of the pro-apoptotic protein Bax expression and demonstrate enhancement of the anti-apoptotic protein Bcl-2 expression in the kidney tissues, suggesting a protective role in the kidneys of diabetic rats. Taken together, these results indicates the synergistic effects of QE and QA in ameliorating hyperglycaemia, hyperlipidemia and insulin resistance in diabetic rats and therefore, open a new window of research on the combinatorial therapy of flavonoids.</description><subject>Animals</subject><subject>Antibacterial agents</subject><subject>Antibiotics. Antiinfectious agents. Antiparasitic agents</subject><subject>Antineoplastic agents</subject><subject>Antioxidants - metabolism</subject><subject>Biological and medical sciences</subject><subject>Chemotherapy</subject><subject>Diabetes mellitus</subject><subject>Diabetes. Impaired glucose tolerance</subject><subject>Drug Synergism</subject><subject>Endocrine pancreas. Apud cells (diseases)</subject><subject>Endocrinopathies</subject><subject>Enzymes - blood</subject><subject>Etiopathogenesis. Screening. Investigations. Target tissue resistance</subject><subject>Food toxicology</subject><subject>Kidney - drug effects</subject><subject>Kidney - pathology</subject><subject>Liver - drug effects</subject><subject>Liver - pathology</subject><subject>Male</subject><subject>Malondialdehyde - metabolism</subject><subject>Medical sciences</subject><subject>Pancreas - drug effects</subject><subject>Pancreas - pathology</subject><subject>Pharmacology. Drug treatments</subject><subject>Quercetin</subject><subject>Quercetin - pharmacology</subject><subject>Quinic acid</subject><subject>Quinic Acid - pharmacology</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Streptozocin</subject><subject>Streptozotocin</subject><subject>Synergistic effect</subject><subject>Toxicology</subject><issn>0278-6915</issn><issn>1873-6351</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9UcGO0zAQtRCI7S58ABfkCxIHEuy4cRL2tFqxgLQSh-2Ji-XY465L6hTbqZTf4guZ0AI3TqOZefNm5j1CXnFWcsbl-13pTC4rxtclkyXj7AlZ8bYRhRQ1f0pWrGraQna8viCXKe0YYw1v5HNyUa27WtQ1X5GfD3OAuPUpe0PBOTCZjo7-mCAayD5QHSxmPmBbG29pP1M9DHD0GrtbmnKcTJ6iHqiFLSAX1sdAcTI_Ah38EeI7-t3bAPNvroMOJoJONPuUJkjLtofNt8IHOxmw1Hrdw3IMEqUP9IbuwTzqcDow5cnOL8gzp4cEL8_ximzuPm5uPxf3Xz99ub25L8y6rXLhLP5o-gp6WEPtQDjRtl0vu1bWTnIjWt0CZ30twGiLWS8E16xpsG4rKa7I2xPtIY4oR8pq75OBYdABxikpLquma1DIBcpPUBPHlCI4dYh-r-OsOFOLU2qn0Cm1OKWYVOgUzrw-00_9HuzfiT_WIODNGaCT0YOLKJxP_3CtbPGTZfn1CQeoxdFDVMl4CKilj-imsqP_zxm_AEK-tQk</recordid><startdate>20140901</startdate><enddate>20140901</enddate><creator>Arya, Aditya</creator><creator>Jamil Al-Obaidi, Mazen M</creator><creator>Shahid, Nayiar</creator><creator>Bin Noordin, Mohamed Ibrahim</creator><creator>Looi, Chung Yeng</creator><creator>Wong, Won Fen</creator><creator>Khaing, Si Lay</creator><creator>Mustafa, Mohd Rais</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U7</scope><scope>C1K</scope><orcidid>https://orcid.org/0000-0003-0296-9037</orcidid></search><sort><creationdate>20140901</creationdate><title>Synergistic effect of quercetin and quinic acid by alleviating structural degeneration in the liver, kidney and pancreas tissues of STZ-induced diabetic rats: A mechanistic study</title><author>Arya, Aditya ; Jamil Al-Obaidi, Mazen M ; Shahid, Nayiar ; Bin Noordin, Mohamed Ibrahim ; Looi, Chung Yeng ; Wong, Won Fen ; Khaing, Si Lay ; Mustafa, Mohd Rais</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c482t-fd953cb2ebe4e5fe3f3889b69865f61c38a8e10b53ecad38ab331a0778a8d263</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Animals</topic><topic>Antibacterial agents</topic><topic>Antibiotics. Antiinfectious agents. Antiparasitic agents</topic><topic>Antineoplastic agents</topic><topic>Antioxidants - metabolism</topic><topic>Biological and medical sciences</topic><topic>Chemotherapy</topic><topic>Diabetes mellitus</topic><topic>Diabetes. Impaired glucose tolerance</topic><topic>Drug Synergism</topic><topic>Endocrine pancreas. Apud cells (diseases)</topic><topic>Endocrinopathies</topic><topic>Enzymes - blood</topic><topic>Etiopathogenesis. Screening. Investigations. Target tissue resistance</topic><topic>Food toxicology</topic><topic>Kidney - drug effects</topic><topic>Kidney - pathology</topic><topic>Liver - drug effects</topic><topic>Liver - pathology</topic><topic>Male</topic><topic>Malondialdehyde - metabolism</topic><topic>Medical sciences</topic><topic>Pancreas - drug effects</topic><topic>Pancreas - pathology</topic><topic>Pharmacology. Drug treatments</topic><topic>Quercetin</topic><topic>Quercetin - pharmacology</topic><topic>Quinic acid</topic><topic>Quinic Acid - pharmacology</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Streptozocin</topic><topic>Streptozotocin</topic><topic>Synergistic effect</topic><topic>Toxicology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Arya, Aditya</creatorcontrib><creatorcontrib>Jamil Al-Obaidi, Mazen M</creatorcontrib><creatorcontrib>Shahid, Nayiar</creatorcontrib><creatorcontrib>Bin Noordin, Mohamed Ibrahim</creatorcontrib><creatorcontrib>Looi, Chung Yeng</creatorcontrib><creatorcontrib>Wong, Won Fen</creatorcontrib><creatorcontrib>Khaing, Si Lay</creatorcontrib><creatorcontrib>Mustafa, Mohd Rais</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>Food and chemical toxicology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Arya, Aditya</au><au>Jamil Al-Obaidi, Mazen M</au><au>Shahid, Nayiar</au><au>Bin Noordin, Mohamed Ibrahim</au><au>Looi, Chung Yeng</au><au>Wong, Won Fen</au><au>Khaing, Si Lay</au><au>Mustafa, Mohd Rais</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Synergistic effect of quercetin and quinic acid by alleviating structural degeneration in the liver, kidney and pancreas tissues of STZ-induced diabetic rats: A mechanistic study</atitle><jtitle>Food and chemical toxicology</jtitle><addtitle>Food Chem Toxicol</addtitle><date>2014-09-01</date><risdate>2014</risdate><volume>71</volume><spage>183</spage><epage>196</epage><pages>183-196</pages><issn>0278-6915</issn><eissn>1873-6351</eissn><coden>FCTOD7</coden><abstract>•The present study was to investigate the synergistic effects of QE and QA on STZ-induced diabetic rats.•Combination dose of QE and QA prevents the hyperglycaemia, oxidative stress and lipid accumulation in diabetic rats.•QE and QA treatment also inhibited the Bax expression and increased the Bcl-2 expression in kidney cells.•Histological studies also revealed the protective role QE and QA in diabetic rats.•Our findings open a new window of research on the combinatorial therapy of flavonoids.
The aim of this study was to investigate the synergistic effects of quercetin (QE) and quinic acid (QA) on a STZ-induced diabetic rat model to determine their potential role in alleviating diabetes and its associated complications. In our study design, diabetic rats were treated with single and combined doses of QE and QA for 45days to analyse their effects on liver, kidney and pancreas tissues. The study result showed that QE and QA treated groups down-regulated hyperglycaemia and oxidative stress by up-regulating insulin and C-peptide levels. Moreover, histological observations of the liver, kidney and pancreas of diabetic rats treated with single and combined doses of QE and QA showed a significant improvement in the structural degeneration. Interestingly, the combination dose of QE and QA (50mg/kg) exhibited maximum inhibition of the pro-apoptotic protein Bax expression and demonstrate enhancement of the anti-apoptotic protein Bcl-2 expression in the kidney tissues, suggesting a protective role in the kidneys of diabetic rats. Taken together, these results indicates the synergistic effects of QE and QA in ameliorating hyperglycaemia, hyperlipidemia and insulin resistance in diabetic rats and therefore, open a new window of research on the combinatorial therapy of flavonoids.</abstract><cop>Oxford</cop><pub>Elsevier Ltd</pub><pmid>24953551</pmid><doi>10.1016/j.fct.2014.06.010</doi><tpages>14</tpages><orcidid>https://orcid.org/0000-0003-0296-9037</orcidid></addata></record> |
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| ispartof | Food and chemical toxicology, 2014-09, Vol.71, p.183-196 |
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| subjects | Animals Antibacterial agents Antibiotics. Antiinfectious agents. Antiparasitic agents Antineoplastic agents Antioxidants - metabolism Biological and medical sciences Chemotherapy Diabetes mellitus Diabetes. Impaired glucose tolerance Drug Synergism Endocrine pancreas. Apud cells (diseases) Endocrinopathies Enzymes - blood Etiopathogenesis. Screening. Investigations. Target tissue resistance Food toxicology Kidney - drug effects Kidney - pathology Liver - drug effects Liver - pathology Male Malondialdehyde - metabolism Medical sciences Pancreas - drug effects Pancreas - pathology Pharmacology. Drug treatments Quercetin Quercetin - pharmacology Quinic acid Quinic Acid - pharmacology Rats Rats, Sprague-Dawley Streptozocin Streptozotocin Synergistic effect Toxicology |
| title | Synergistic effect of quercetin and quinic acid by alleviating structural degeneration in the liver, kidney and pancreas tissues of STZ-induced diabetic rats: A mechanistic study |
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