Correlation of transcriptomic responses and metal bioaccumulation in Mytilus edulis L. reveals early indicators of stress

•Gene expression and metal tissue concentrations were compared in Mytilus edulis.•Expression levels of several transcripts correlated with metal concentrations.•Transcripts involved in the unfolded protein response (UPR) were induced.•Integration of transcriptomics and tissue levels provides insight...

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Veröffentlicht in:	Aquatic toxicology 2014-10, Vol.155, p.129-141
Hauptverfasser:	Poynton, Helen C., Robinson, William E., Blalock, Bonnie J., Hannigan, Robyn E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal, plant and microbial ecology Animals Applied ecology Biological and medical sciences Biomarkers - metabolism Cadmium Cadmium - metabolism Cadmium - toxicity Ecotoxicology, biological effects of pollution Effects of pollution and side effects of pesticides on protozoa and invertebrates Environmental Monitoring Fundamental and applied biological sciences. Psychology Gene Expression Regulation - drug effects Gills - metabolism Lead Lead - metabolism Lead - toxicity Metals - metabolism Metals - toxicity Mytilus edulis Mytilus edulis - drug effects Mytilus edulis - physiology Protein Array Analysis Quantitative RT-PCR Stress, Physiological - drug effects Tissue residue approach Toxicogenomics Transcriptome Water Pollutants, Chemical - toxicity
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