Endophilin-1 regulates blood–brain barrier permeability by controlling ZO-1 and occludin expression via the EGFR–ERK1/2 pathway

Abstract The blood–brain barrier (BBB) plays a pivotal role in maintenance and regulation of the neural microenvironment. Brain endothelial cells (BECs), held together by tight junctions (TJs), have a primary role in restricting the permeability of the BBB. Endophilin-1 is a multifunctional protein...

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Veröffentlicht in:	Brain research 2014-07, Vol.1573, p.17-26
Hauptverfasser:	Liu, Wenjing, Wang, Ping, Shang, Chao, Chen, Lin, Cai, Heng, Ma, Jun, Yao, Yilong, Shang, Xiuli, Xue, Yixue
Format:	Artikel
Sprache:	eng
Schlagworte:	Acyltransferases - genetics Acyltransferases - metabolism Biological and medical sciences Blood-Brain Barrier - drug effects Blood-Brain Barrier - physiology Blood–brain barrier permeability Blotting, Western Capillary Permeability - drug effects Capillary Permeability - physiology Cell Line Cerebral circulation. Blood-brain barrier. Choroid plexus. Cerebrospinal fluid. Circumventricular organ. Meninges Electric Impedance Endophilin-1 Epithelial growth factor receptor Extracellular signal-regulated kinases Fluorescent Antibody Technique Fundamental and applied biological sciences. Psychology Gene Expression Regulation Humans Immunoprecipitation MAP Kinase Signaling System - drug effects MAP Kinase Signaling System - physiology Neurology Occludin - metabolism Receptor, Epidermal Growth Factor - metabolism Tight junction Tight Junction Proteins - metabolism Transfection Vertebrates: nervous system and sense organs Zonula Occludens-1 Protein - metabolism
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