Sensory-motor performance after acute glutathione depletion by l-buthionine sulfoximine injection into substantia nigra pars compacta

•Transient glutathione depletion leads to sensory-motor impairment in rats.•Sensory-motor impairment is accompanied TH-positive cell loss in the SNpc.•TH-positive cell loss was not related to oxidative damage.•Glutathione depletion is accompanied by antioxidant response in SNpc. Glutathione is the m...

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Veröffentlicht in:	Behavioural brain research 2014-09, Vol.271, p.286-293
Hauptverfasser:	Díaz-Hung, Mei-Li, Blanco, Lisette, Pavón, Nancy, León, Rilda, Estupiñan, Bárbara, Orta, Eduardo, Martínez, Klaudia, Fernández, Isabel
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antioxidant enzymes Astrocytes Behavioral psychophysiology Biological and medical sciences Buthionine Sulfoximine - toxicity Corpus Striatum - metabolism Dopaminergic cell Dopaminergic Neurons - drug effects Dopaminergic Neurons - metabolism Fundamental and applied biological sciences. Psychology Glial Fibrillary Acidic Protein - metabolism Glutathione Glutathione - metabolism Locomotion - drug effects Male Malondialdehyde Microinjections Motor Activity - drug effects Pars Compacta - metabolism Psychology. Psychoanalysis. Psychiatry Psychology. Psychophysiology Psychomotor Performance - drug effects Rats Rats, Sprague-Dawley Sensory-motor function Tyrosine 3-Monooxygenase - metabolism Vertebrates: nervous system and sense organs
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