Uncoupling protein 2 −866G/A and uncoupling protein 3 −55C/T polymorphisms in young South African Indian coronary artery disease patients
Uncoupling proteins (UCPs) 2 and 3 play an important role in the regulation of oxidative stress which contributes to chronic inflammation. Promoter polymorphisms of these genes have been linked to chronic diseases including heart disease and type II diabetes mellitus in several populations. This is...
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| Veröffentlicht in: | Gene 2013-07, Vol.524 (2), p.79-83 |
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| creator | Phulukdaree, Alisa Moodley, Devapregasan Khan, Sajidah Chuturgoon, Anil A. |
| description | Uncoupling proteins (UCPs) 2 and 3 play an important role in the regulation of oxidative stress which contributes to chronic inflammation. Promoter polymorphisms of these genes have been linked to chronic diseases including heart disease and type II diabetes mellitus in several populations. This is the first investigation of the UCP2 −866G/A rs659366 and UCP3 −55C/T rs1800849 polymorphisms in young South African (SA) Indians with coronary artery disease (CAD).
A total of 300 subjects were recruited into this study of which 100 were SA Indian males with CAD, 100 age- (range 24–45years), gender- and race-matched controls and 100 age-matched black SA males. The frequency of the UCP2 −866G/A and UPC3 −55C/T genotypes was assessed by polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP).
The heterozygous UCP2 −866G/A and homozygous UCP3 −55C/C genotypes occurred at highest frequency in CAD patients (60% and 64%, respectively) compared to SA Indian controls (52% and 63%) and SA Black controls (50% and 58%). The UCP2 −886G/A (OR=1.110; 95% CI=0.7438–1.655; p=0.6835) and UCP3 −55C/T (OR=0.788; 95% CI=0.482–1.289; p=0.382) polymorphisms did not influence the risk of CAD.
The rare homozygous UCP3 −55T/T genotype was associated with highest fasting glucose (11.87±3.7mmol/L vs. C/C:6.11±0.27mmol/L and C/T:6.48±0.57mmol/L, p=0.0025), HbA1c (10.05±2.57% vs. C/C:6.44±0.21% and C/T:6.76±0.35%, p=0.0006) and triglycerides (6.47±1.7mmol/L vs. C/C:2.33±0.17mmol/L and C/T:2.06±0.25mmol/L, p |
| doi_str_mv | 10.1016/j.gene.2013.04.048 |
| format | Article |
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A total of 300 subjects were recruited into this study of which 100 were SA Indian males with CAD, 100 age- (range 24–45years), gender- and race-matched controls and 100 age-matched black SA males. The frequency of the UCP2 −866G/A and UPC3 −55C/T genotypes was assessed by polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP).
The heterozygous UCP2 −866G/A and homozygous UCP3 −55C/C genotypes occurred at highest frequency in CAD patients (60% and 64%, respectively) compared to SA Indian controls (52% and 63%) and SA Black controls (50% and 58%). The UCP2 −886G/A (OR=1.110; 95% CI=0.7438–1.655; p=0.6835) and UCP3 −55C/T (OR=0.788; 95% CI=0.482–1.289; p=0.382) polymorphisms did not influence the risk of CAD.
The rare homozygous UCP3 −55T/T genotype was associated with highest fasting glucose (11.87±3.7mmol/L vs. C/C:6.11±0.27mmol/L and C/T:6.48±0.57mmol/L, p=0.0025), HbA1c (10.05±2.57% vs. C/C:6.44±0.21% and C/T:6.76±0.35%, p=0.0006) and triglycerides (6.47±1.7mmol/L vs. C/C:2.33±0.17mmol/L and C/T:2.06±0.25mmol/L, p<0.0001) in CAD patients.
The frequency of the UCP2 −866G/A and UCP3 −55C/T polymorphisms was similar in our SA Indian and SA Black groups. The presence of the UCP2 −866G/A and UCP3 −55C/T polymorphisms does not influence the risk of CAD in young South African Indian CAD patients.
•The frequency of UCP2 -866G/A and UCP3 -55C/T were similar in SA Indians and Blacks.•These SNP’s do not influence the risk of CAD in young SA Indian patients.•Higher levels of hsCRP was found in UCP2 GG and UCP3 TT patient groups.•UCP3 -55C/T SNP may influence the risk of metabolic syndrome in SA Indians with CAD.</description><identifier>ISSN: 0378-1119</identifier><identifier>EISSN: 1879-0038</identifier><identifier>DOI: 10.1016/j.gene.2013.04.048</identifier><identifier>PMID: 23639961</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Adult ; African Continental Ancestry Group - genetics ; Blood Glucose - analysis ; Case-Control Studies ; chronic diseases ; Coronary artery disease ; Coronary Artery Disease - ethnology ; Coronary Artery Disease - genetics ; fasting ; Gene Frequency ; genes ; Genetic Association Studies ; Genotype ; glucose ; Glycated Hemoglobin A - analysis ; heterozygosity ; homozygosity ; Humans ; India - ethnology ; inflammation ; Ion Channels - genetics ; Male ; males ; Middle Aged ; Mitochondrial Proteins - genetics ; noninsulin-dependent diabetes mellitus ; Odds Ratio ; oxidative stress ; patients ; Polymerase Chain Reaction ; Polymorphism ; Polymorphism, Restriction Fragment Length ; Polymorphism, Single Nucleotide ; Promoter Regions, Genetic ; proteins ; restriction fragment length polymorphism ; risk ; Risk Factors ; South Africa - epidemiology ; triacylglycerols ; Triglycerides - analysis ; Uncoupling protein ; Uncoupling Protein 2 ; Uncoupling Protein 3 ; Young Adult</subject><ispartof>Gene, 2013-07, Vol.524 (2), p.79-83</ispartof><rights>2013 Elsevier B.V.</rights><rights>Copyright © 2013 Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c413t-7e5ca92e5fb12013782268baaf80389f4cad6e30e7d05a10d5907482fcc6d763</citedby><cites>FETCH-LOGICAL-c413t-7e5ca92e5fb12013782268baaf80389f4cad6e30e7d05a10d5907482fcc6d763</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.gene.2013.04.048$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23639961$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Phulukdaree, Alisa</creatorcontrib><creatorcontrib>Moodley, Devapregasan</creatorcontrib><creatorcontrib>Khan, Sajidah</creatorcontrib><creatorcontrib>Chuturgoon, Anil A.</creatorcontrib><title>Uncoupling protein 2 −866G/A and uncoupling protein 3 −55C/T polymorphisms in young South African Indian coronary artery disease patients</title><title>Gene</title><addtitle>Gene</addtitle><description>Uncoupling proteins (UCPs) 2 and 3 play an important role in the regulation of oxidative stress which contributes to chronic inflammation. Promoter polymorphisms of these genes have been linked to chronic diseases including heart disease and type II diabetes mellitus in several populations. This is the first investigation of the UCP2 −866G/A rs659366 and UCP3 −55C/T rs1800849 polymorphisms in young South African (SA) Indians with coronary artery disease (CAD).
A total of 300 subjects were recruited into this study of which 100 were SA Indian males with CAD, 100 age- (range 24–45years), gender- and race-matched controls and 100 age-matched black SA males. The frequency of the UCP2 −866G/A and UPC3 −55C/T genotypes was assessed by polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP).
The heterozygous UCP2 −866G/A and homozygous UCP3 −55C/C genotypes occurred at highest frequency in CAD patients (60% and 64%, respectively) compared to SA Indian controls (52% and 63%) and SA Black controls (50% and 58%). The UCP2 −886G/A (OR=1.110; 95% CI=0.7438–1.655; p=0.6835) and UCP3 −55C/T (OR=0.788; 95% CI=0.482–1.289; p=0.382) polymorphisms did not influence the risk of CAD.
The rare homozygous UCP3 −55T/T genotype was associated with highest fasting glucose (11.87±3.7mmol/L vs. C/C:6.11±0.27mmol/L and C/T:6.48±0.57mmol/L, p=0.0025), HbA1c (10.05±2.57% vs. C/C:6.44±0.21% and C/T:6.76±0.35%, p=0.0006) and triglycerides (6.47±1.7mmol/L vs. C/C:2.33±0.17mmol/L and C/T:2.06±0.25mmol/L, p<0.0001) in CAD patients.
The frequency of the UCP2 −866G/A and UCP3 −55C/T polymorphisms was similar in our SA Indian and SA Black groups. The presence of the UCP2 −866G/A and UCP3 −55C/T polymorphisms does not influence the risk of CAD in young South African Indian CAD patients.
•The frequency of UCP2 -866G/A and UCP3 -55C/T were similar in SA Indians and Blacks.•These SNP’s do not influence the risk of CAD in young SA Indian patients.•Higher levels of hsCRP was found in UCP2 GG and UCP3 TT patient groups.•UCP3 -55C/T SNP may influence the risk of metabolic syndrome in SA Indians with CAD.</description><subject>Adult</subject><subject>African Continental Ancestry Group - genetics</subject><subject>Blood Glucose - analysis</subject><subject>Case-Control Studies</subject><subject>chronic diseases</subject><subject>Coronary artery disease</subject><subject>Coronary Artery Disease - ethnology</subject><subject>Coronary Artery Disease - genetics</subject><subject>fasting</subject><subject>Gene Frequency</subject><subject>genes</subject><subject>Genetic Association Studies</subject><subject>Genotype</subject><subject>glucose</subject><subject>Glycated Hemoglobin A - analysis</subject><subject>heterozygosity</subject><subject>homozygosity</subject><subject>Humans</subject><subject>India - ethnology</subject><subject>inflammation</subject><subject>Ion Channels - genetics</subject><subject>Male</subject><subject>males</subject><subject>Middle Aged</subject><subject>Mitochondrial Proteins - genetics</subject><subject>noninsulin-dependent diabetes mellitus</subject><subject>Odds Ratio</subject><subject>oxidative stress</subject><subject>patients</subject><subject>Polymerase Chain Reaction</subject><subject>Polymorphism</subject><subject>Polymorphism, Restriction Fragment Length</subject><subject>Polymorphism, Single Nucleotide</subject><subject>Promoter Regions, Genetic</subject><subject>proteins</subject><subject>restriction fragment length polymorphism</subject><subject>risk</subject><subject>Risk Factors</subject><subject>South Africa - epidemiology</subject><subject>triacylglycerols</subject><subject>Triglycerides - analysis</subject><subject>Uncoupling protein</subject><subject>Uncoupling Protein 2</subject><subject>Uncoupling Protein 3</subject><subject>Young Adult</subject><issn>0378-1119</issn><issn>1879-0038</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc9uEzEQxi0EoqHwAhzARy6b-M_a65W4RBEtlSpxaHq2HHs2dZS1F3sXKW_AhQuP2CfBqxQuSGCNNAf_5tP3zSD0lpIlJVSuDss9BFgyQvmS1KXUM7SgqmkrQrh6jhaEN6qilLYX6FXOB1KeEOwlumBc8raVdIF-3Acbp-Howx4PKY7gA2b48ftPJeX1ao1NcHj6G-EzIsRmtcVDPJ76mIYHn_uMy98pToW8i9P4gNdd8tYEfBOcL83GFINJJ2zSCKU5n8FkwIMZPYQxv0YvOnPM8OapX6Lt1aft5nN1--X6ZrO-rWxN-Vg1IKxpGYhuR-f0jWJMqp0xnSrB2662xkngBBpHhKHEiZY0tWKdtdI1kl-iD2fZEufrBHnUvc8WjkcTIE5ZU8maVrairPG_KJdSNEVcFZSdUZtizgk6PSTfl7SaEj0fTB_0fDA9W9akLjUPvXvSn3Y9uD8jvy9UgPdnoDNRm33yWd_fFYVijtS1ELwQH88ElI1985B0tmWbFpxPYEftov-Xg18MQ7Ib</recordid><startdate>20130725</startdate><enddate>20130725</enddate><creator>Phulukdaree, Alisa</creator><creator>Moodley, Devapregasan</creator><creator>Khan, Sajidah</creator><creator>Chuturgoon, Anil A.</creator><general>Elsevier B.V</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope></search><sort><creationdate>20130725</creationdate><title>Uncoupling protein 2 −866G/A and uncoupling protein 3 −55C/T polymorphisms in young South African Indian coronary artery disease patients</title><author>Phulukdaree, Alisa ; Moodley, Devapregasan ; Khan, Sajidah ; Chuturgoon, Anil A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c413t-7e5ca92e5fb12013782268baaf80389f4cad6e30e7d05a10d5907482fcc6d763</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Adult</topic><topic>African Continental Ancestry Group - genetics</topic><topic>Blood Glucose - analysis</topic><topic>Case-Control Studies</topic><topic>chronic diseases</topic><topic>Coronary artery disease</topic><topic>Coronary Artery Disease - ethnology</topic><topic>Coronary Artery Disease - genetics</topic><topic>fasting</topic><topic>Gene Frequency</topic><topic>genes</topic><topic>Genetic Association Studies</topic><topic>Genotype</topic><topic>glucose</topic><topic>Glycated Hemoglobin A - analysis</topic><topic>heterozygosity</topic><topic>homozygosity</topic><topic>Humans</topic><topic>India - ethnology</topic><topic>inflammation</topic><topic>Ion Channels - genetics</topic><topic>Male</topic><topic>males</topic><topic>Middle Aged</topic><topic>Mitochondrial Proteins - genetics</topic><topic>noninsulin-dependent diabetes mellitus</topic><topic>Odds Ratio</topic><topic>oxidative stress</topic><topic>patients</topic><topic>Polymerase Chain Reaction</topic><topic>Polymorphism</topic><topic>Polymorphism, Restriction Fragment Length</topic><topic>Polymorphism, Single Nucleotide</topic><topic>Promoter Regions, Genetic</topic><topic>proteins</topic><topic>restriction fragment length polymorphism</topic><topic>risk</topic><topic>Risk Factors</topic><topic>South Africa - epidemiology</topic><topic>triacylglycerols</topic><topic>Triglycerides - analysis</topic><topic>Uncoupling protein</topic><topic>Uncoupling Protein 2</topic><topic>Uncoupling Protein 3</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Phulukdaree, Alisa</creatorcontrib><creatorcontrib>Moodley, Devapregasan</creatorcontrib><creatorcontrib>Khan, Sajidah</creatorcontrib><creatorcontrib>Chuturgoon, Anil A.</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><jtitle>Gene</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Phulukdaree, Alisa</au><au>Moodley, Devapregasan</au><au>Khan, Sajidah</au><au>Chuturgoon, Anil A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Uncoupling protein 2 −866G/A and uncoupling protein 3 −55C/T polymorphisms in young South African Indian coronary artery disease patients</atitle><jtitle>Gene</jtitle><addtitle>Gene</addtitle><date>2013-07-25</date><risdate>2013</risdate><volume>524</volume><issue>2</issue><spage>79</spage><epage>83</epage><pages>79-83</pages><issn>0378-1119</issn><eissn>1879-0038</eissn><abstract>Uncoupling proteins (UCPs) 2 and 3 play an important role in the regulation of oxidative stress which contributes to chronic inflammation. Promoter polymorphisms of these genes have been linked to chronic diseases including heart disease and type II diabetes mellitus in several populations. This is the first investigation of the UCP2 −866G/A rs659366 and UCP3 −55C/T rs1800849 polymorphisms in young South African (SA) Indians with coronary artery disease (CAD).
A total of 300 subjects were recruited into this study of which 100 were SA Indian males with CAD, 100 age- (range 24–45years), gender- and race-matched controls and 100 age-matched black SA males. The frequency of the UCP2 −866G/A and UPC3 −55C/T genotypes was assessed by polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP).
The heterozygous UCP2 −866G/A and homozygous UCP3 −55C/C genotypes occurred at highest frequency in CAD patients (60% and 64%, respectively) compared to SA Indian controls (52% and 63%) and SA Black controls (50% and 58%). The UCP2 −886G/A (OR=1.110; 95% CI=0.7438–1.655; p=0.6835) and UCP3 −55C/T (OR=0.788; 95% CI=0.482–1.289; p=0.382) polymorphisms did not influence the risk of CAD.
The rare homozygous UCP3 −55T/T genotype was associated with highest fasting glucose (11.87±3.7mmol/L vs. C/C:6.11±0.27mmol/L and C/T:6.48±0.57mmol/L, p=0.0025), HbA1c (10.05±2.57% vs. C/C:6.44±0.21% and C/T:6.76±0.35%, p=0.0006) and triglycerides (6.47±1.7mmol/L vs. C/C:2.33±0.17mmol/L and C/T:2.06±0.25mmol/L, p<0.0001) in CAD patients.
The frequency of the UCP2 −866G/A and UCP3 −55C/T polymorphisms was similar in our SA Indian and SA Black groups. The presence of the UCP2 −866G/A and UCP3 −55C/T polymorphisms does not influence the risk of CAD in young South African Indian CAD patients.
•The frequency of UCP2 -866G/A and UCP3 -55C/T were similar in SA Indians and Blacks.•These SNP’s do not influence the risk of CAD in young SA Indian patients.•Higher levels of hsCRP was found in UCP2 GG and UCP3 TT patient groups.•UCP3 -55C/T SNP may influence the risk of metabolic syndrome in SA Indians with CAD.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>23639961</pmid><doi>10.1016/j.gene.2013.04.048</doi><tpages>5</tpages></addata></record> |
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| subjects | Adult African Continental Ancestry Group - genetics Blood Glucose - analysis Case-Control Studies chronic diseases Coronary artery disease Coronary Artery Disease - ethnology Coronary Artery Disease - genetics fasting Gene Frequency genes Genetic Association Studies Genotype glucose Glycated Hemoglobin A - analysis heterozygosity homozygosity Humans India - ethnology inflammation Ion Channels - genetics Male males Middle Aged Mitochondrial Proteins - genetics noninsulin-dependent diabetes mellitus Odds Ratio oxidative stress patients Polymerase Chain Reaction Polymorphism Polymorphism, Restriction Fragment Length Polymorphism, Single Nucleotide Promoter Regions, Genetic proteins restriction fragment length polymorphism risk Risk Factors South Africa - epidemiology triacylglycerols Triglycerides - analysis Uncoupling protein Uncoupling Protein 2 Uncoupling Protein 3 Young Adult |
| title | Uncoupling protein 2 −866G/A and uncoupling protein 3 −55C/T polymorphisms in young South African Indian coronary artery disease patients |
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