Neurofibromin inactivation impairs osteocyte development in Nf1Prx1 and Nf1Col1 mouse models

Abstract Neurofibromin has been identified as a critical regulator of osteoblast differentiation. Osteoblast specific inactivation of neurofibromin in mice results in a high bone mass phenotype and hyperosteoidosis. Here, we show that inactivation of the Nf1 gene also impairs osteocyte development....

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Veröffentlicht in:	Bone (New York, N.Y.) N.Y.), 2014-09, Vol.66, p.155-162
Hauptverfasser:	Kühnisch, Jirko, Seto, Jong, Lange, Claudia, Stumpp, Sabine, Kobus, Karolina, Grohmann, Julia, Elefteriou, Florent, Fratzl, Peter, Mundlos, Stefan, Kolanczyk, Mateusz
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Bone Calcification, Physiologic - genetics Cell Shape Cell Survival Energy Metabolism Extracellular Matrix - metabolism Fundamental and applied biological sciences. Psychology Gene Expression Regulation Humerus - pathology MAPK Medical sciences Mice Mice, Mutant Strains Models, Animal neurofibromin Neurofibromin 1 - deficiency Neurofibromin 1 - metabolism Neurology NF1 Orthopedics osteocyte Osteocytes - metabolism Osteocytes - pathology Osteocytes - ultrastructure Stress, Mechanical Transcription, Genetic Tumors of the nervous system. Phacomatoses Vertebrates: anatomy and physiology, studies on body, several organs or systems
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