Pregnane X receptor upregulates ABC-transporter Abcg2 and Abcb1 at the blood-brain barrier

Abstract ATP-driven efflux transporters are important, selective elements of the blood-brain barrier. Abcg2 (also brain multidrug resistance protein) and Abcb1 (P-glycoprotein) belong to the best known ABC-transporters which limit the access of therapeutic drugs to the brain and impair pharmacothera...

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Veröffentlicht in:	Brain research 2013-01, Vol.1491 (23), p.1-13
Hauptverfasser:	Lemmen, Julia, Tozakidis, Iasson E.P, Galla, Hans-Joachim
Format:	Artikel
Sprache:	eng
Schlagworte:	ABC transporters Abcb1 (P-glycoprotein) Abcb2 (brain multidrug resistance protein/breast cancer related protein) active transport Animals ATP Binding Cassette Transporter, Sub-Family B - biosynthesis ATP Binding Cassette Transporter, Sub-Family B - genetics ATP-Binding Cassette, Sub-Family B, Member 1 - biosynthesis ATP-Binding Cassette, Sub-Family B, Member 1 - genetics Benzimidazoles Biological and medical sciences Blood-brain barrier Blood-Brain Barrier - drug effects Blotting, Western brain Capillaries - drug effects Capillaries - metabolism Cells, Cultured Cerebral circulation. Blood-brain barrier. Choroid plexus. Cerebrospinal fluid. Circumventricular organ. Meninges Electric Stimulation endothelial cells Endothelial Cells - metabolism Fluorescent Dyes Fundamental and applied biological sciences. Psychology gene expression regulation humans hyperforin multiple drug resistance Neurology pharmacokinetics Phloroglucinol - analogs & derivatives Phloroglucinol - pharmacology Porcine brain capillary endothelial cells Pregnane X receptor protein synthesis quantitative polymerase chain reaction Real-Time Polymerase Chain Reaction Receptors, Steroid - drug effects Regulation rifampicin Rifampin - pharmacology RNA RNA - biosynthesis RNA - genetics Stimulation, Chemical Swine Terpenes - pharmacology transcription factors Up-Regulation - drug effects Vertebrates: nervous system and sense organs Western blotting xenobiotics
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