Effects of sodium fluoride on MAPKs signaling pathway in the gills of a freshwater teleost, Cyprinus carpio

•ERK relative activation decreased and JNK activation increased as fluoride level.•MAPKs inhibitors effectively prevented JNK induction and ERK inhibition.•Activation of JNK and inactivation of ERK were caused by oxidative stress.•JNK activation and ERK inactivation mechanism play a role in gill dam...

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Veröffentlicht in:	Aquatic toxicology 2014-07, Vol.152, p.164-172
Hauptverfasser:	Cao, Jinling, Chen, Jianjie, Wang, Jundong, Klerks, Paul, Xie, Lingtian
Format:	Artikel
Sprache:	eng
Schlagworte:	Agnatha. Pisces Animal, plant and microbial ecology Animals Apoptosis - drug effects Applied ecology Biological and medical sciences Carps - physiology Caspase 3 - metabolism Cell Line Cyprinus carpio Ecotoxicology, biological effects of pollution Effects of pollution and side effects of pesticides on vertebrates Fluoride Fresh Water Fundamental and applied biological sciences. Psychology Gill Gills - cytology Gills - drug effects Gills - enzymology MAPKs signaling pathway Mitochondria - genetics Mitogen-Activated Protein Kinases - metabolism Molecular Sequence Data RNA, Ribosomal, 16S - genetics Signal Transduction - drug effects Sodium Fluoride - toxicity Teleostei Water Pollutants, Chemical - toxicity Western blotting
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