Disparate roles for TNF-alpha and Fas ligand in concanavalin A-induced hepatitis

Apoptosis is a physiologic process that serves to eliminate cells during development or in response to immunologic regulation. In acute inflammation, however, apoptosis triggered by the overproduction of "death factors" such as TNF-alpha or Fas ligand (FasL) may contribute to tissue injury...

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Veröffentlicht in:	The Journal of immunology (1950) 1998-04, Vol.160 (8), p.4082-4089
Hauptverfasser:	Ksontini, R, Colagiovanni, D B, Josephs, M D, Edwards, 3rd, C K, Tannahill, C L, Solorzano, C C, Norman, J, Denham, W, Clare-Salzler, M, MacKay, S L, Moldawer, L L
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Base Sequence Caspase 1 Chemical and Drug Induced Liver Injury - etiology Chemical and Drug Induced Liver Injury - immunology Chemical and Drug Induced Liver Injury - physiopathology Concanavalin A - toxicity Cysteine Endopeptidases - deficiency Cysteine Endopeptidases - physiology DNA Primers - genetics Fas Ligand Protein Liver - drug effects Liver - immunology Liver - pathology Male Membrane Glycoproteins - antagonists & inhibitors Membrane Glycoproteins - genetics Membrane Glycoproteins - physiology Mice Mice, Inbred C57BL Polymerase Chain Reaction RNA, Messenger - genetics RNA, Messenger - metabolism Tumor Necrosis Factor-alpha - antagonists & inhibitors Tumor Necrosis Factor-alpha - genetics Tumor Necrosis Factor-alpha - physiology Up-Regulation - drug effects
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