Early administration of tumor necrosis factor-alpha antagonist promotes survival of transplanted neural stem cells and axon myelination after spinal cord injury in rats

Abstract Neural stem cell (NSC) transplantation has been reported to be a leading strategy to stimulate neuroplasticity, repair neuronal loss and promote the morphologic and functional recovery of spinal cord injury (SCI). However, massive death of transplanted NSCs is still a problem, which is cons...

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Veröffentlicht in:	Brain research 2014-08, Vol.1575, p.87-100
Hauptverfasser:	Wang, Le, Wei, Fu-xin, Cen, Jing-sheng, Ping, Su-ning, Li, Zi-qing, Chen, Ning-ning, Cui, Shang-bin, Wan, Yong, Liu, Shao-yu
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Biological and medical sciences Cell Survival Drug Therapy, Combination Etanercept Evoked Potentials, Motor Female Functional recovery Fundamental and applied biological sciences. Psychology Immunoglobulin G - administration & dosage Immunoglobulin G - therapeutic use Motor Activity - drug effects Nerve Fibers, Myelinated - drug effects Nerve Fibers, Myelinated - pathology Nerve Regeneration Neural stem cells Neural Stem Cells - drug effects Neural Stem Cells - physiology Neural Stem Cells - transplantation Neurology Neuroprotective Agents - administration & dosage Neuroprotective Agents - therapeutic use Rats Rats, Sprague-Dawley Receptors, Tumor Necrosis Factor - administration & dosage Receptors, Tumor Necrosis Factor - therapeutic use Spinal Cord Injuries - drug therapy Spinal Cord Injuries - metabolism Spinal Cord Injuries - physiopathology Spinal cord injury TNF-α Tumor Necrosis Factor-alpha - antagonists & inhibitors Tumor Necrosis Factor-alpha - metabolism Vertebrates: nervous system and sense organs
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