Icariside II improves cerebral microcirculatory disturbance and alleviates hippocampal injury in gerbils after ischemia–reperfusion

Abstract Objective : the purpose of the present study was to examine the protective effect of Icariside II (IS) on cerebral microcirculatory disturbance and neuronal injury in hippocampal CA1 region induced by global cerebral I/R and the underlying mechanism. Methods : male Mongolian gerbils (50–70...

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Veröffentlicht in:	Brain research 2014-07, Vol.1573, p.63-73
Hauptverfasser:	Yan, Ben-Yong, Pan, Chun-Shui, Mao, Xiao-Wei, Yang, Lei, Liu, Yu-Ying, Yan, Li, Mu, Hong-Na, Wang, Chuan-She, Sun, Kai, Liao, Fu-Long, Fan, Jing-Yu, Wang, Xue-Mei, Han, Jing-Yan
Format:	Artikel
Sprache:	eng
Schlagworte:	Albumin leakage Animals Apoptosis Biological and medical sciences Brain - blood supply Brain - drug effects Brain - pathology Brain - physiopathology Brain Ischemia - drug therapy Brain Ischemia - pathology Brain Ischemia - physiopathology CA1 Region, Hippocampal - blood supply CA1 Region, Hippocampal - drug effects CA1 Region, Hippocampal - pathology CA1 Region, Hippocampal - physiopathology Carotid Artery, Common Cerebrovascular Circulation - drug effects Cerebrovascular Circulation - physiology Complex I Flavonoids - pharmacology Fundamental and applied biological sciences. Psychology Gerbillinae Leukocyte adhesion Male Meriones unguiculatus Microcirculation - drug effects Microcirculation - physiology Mitochondria Neurology Neuroprotective Agents - pharmacology Reperfusion Injury - drug therapy Reperfusion Injury - pathology Reperfusion Injury - physiopathology Time Factors Vertebrates: nervous system and sense organs
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