Overexpression of B7-H3 in CD14+ monocytes is associated with renal cell carcinoma progression
Renal cell carcinoma (RCC) is well known as a typical hypervascular tumor and has a high mortality rate. Tumor-induced angiogenesis is crucial for tumor growth and metastasis. It also plays an important role in the development and progression of RCC. However, the molecular mechanism is still unclear...
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| Veröffentlicht in: | Medical oncology (Northwood, London, England) London, England), 2014-12, Vol.31 (12), p.349-349, Article 349 |
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| container_title | Medical oncology (Northwood, London, England) |
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| creator | Li, Miao Zhang, Guangbo Zhang, Xuefeng Lv, Guanglin Wei, Xuedong Yuan, Hexing Hou, Jianquan |
| description | Renal cell carcinoma (RCC) is well known as a typical hypervascular tumor and has a high mortality rate. Tumor-induced angiogenesis is crucial for tumor growth and metastasis. It also plays an important role in the development and progression of RCC. However, the molecular mechanism is still unclear. In our study, we evaluated the expression level of B7-H3 in CD14
+
monocytes in 56 paired RCC samples and distant normal tissues by flow cytometry and located the co-expression of B7-H3 and CD14 by immunohistochemistry. In addition, we analyzed its association with clinical pathologic features through Chi-square test and Fisher exact test. Results showed that B7-H3 and CD14 co-expressed in tumor stroma surrounding the vessels and that the level of B7-H3 expression was higher in tumor than in normal tissues (63.42 ± 11.92 vs. 15.59 ± 3.01,
P
|
| doi_str_mv | 10.1007/s12032-014-0349-1 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1627951038</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1627951038</sourcerecordid><originalsourceid>FETCH-LOGICAL-c414t-8d8a12feec1bc3a6a059eb362e24def983580b3735750975317f410f408ac3593</originalsourceid><addsrcrecordid>eNp9kE1PG0EMhkdVUUNpf0Av1RwrVVvs-diPI4RSkCJxAYlTR5OJl26U3QnjDZB_z0RJOXKxLfn1a_sR4hvCLwSoThkVaFUAmgK0aQr8II7R2lxovP-Ya22rAmwJE_GZeQmg0Krmk5goa7AEi8fi780TJXpZJ2Lu4iBjK8-r4krLbpDTCzQ_ZR-HGLYjsexYeuYYOj_SQj534z-ZaPArGWiVg0-hG2Lv5TrFh4PfF3HU-hXT10M-EXeXv2-nV8Xs5s_19GxWBINmLOpF7VG1RAHnQfvSg21orktFyiyobWpta5jrKv9joamsxqo1CK2B2gdtG30ifux98-7HDfHo-o53Z_mB4oYdlqpqLIKusxT30pAic6LWrVPX-7R1CG6H1e2xuozV7bA6zDPfD_abeU-Lt4n_HLNA7QWcW8MDJbeMm5TZ8DuurxrrgUk</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1627951038</pqid></control><display><type>article</type><title>Overexpression of B7-H3 in CD14+ monocytes is associated with renal cell carcinoma progression</title><source>MEDLINE</source><source>SpringerLink Journals - AutoHoldings</source><creator>Li, Miao ; Zhang, Guangbo ; Zhang, Xuefeng ; Lv, Guanglin ; Wei, Xuedong ; Yuan, Hexing ; Hou, Jianquan</creator><creatorcontrib>Li, Miao ; Zhang, Guangbo ; Zhang, Xuefeng ; Lv, Guanglin ; Wei, Xuedong ; Yuan, Hexing ; Hou, Jianquan</creatorcontrib><description>Renal cell carcinoma (RCC) is well known as a typical hypervascular tumor and has a high mortality rate. Tumor-induced angiogenesis is crucial for tumor growth and metastasis. It also plays an important role in the development and progression of RCC. However, the molecular mechanism is still unclear. In our study, we evaluated the expression level of B7-H3 in CD14
+
monocytes in 56 paired RCC samples and distant normal tissues by flow cytometry and located the co-expression of B7-H3 and CD14 by immunohistochemistry. In addition, we analyzed its association with clinical pathologic features through Chi-square test and Fisher exact test. Results showed that B7-H3 and CD14 co-expressed in tumor stroma surrounding the vessels and that the level of B7-H3 expression was higher in tumor than in normal tissues (63.42 ± 11.92 vs. 15.59 ± 3.01,
P
< 0.0001). Furthermore, the expression level was significantly associated with RCC stage (
P
= 0.000), nodal metastasis (
P
= 0.003), distant metastasis (
P
= 0.020), and nuclear grade (
P
= 0.004). Conclusively, we found the phenomenon that B7-H3 and CD14 co-expressed in RCC tissues. The level of expression was closely associated with the tumor’s progression, indicating that B7-H3 might play an important role in angiogenesis of RCC mediated by CD14
+
monocytes.</description><identifier>ISSN: 1357-0560</identifier><identifier>EISSN: 1559-131X</identifier><identifier>DOI: 10.1007/s12032-014-0349-1</identifier><identifier>PMID: 25416051</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Adult ; Aged ; Aged, 80 and over ; B7 Antigens - metabolism ; Carcinoma, Renal Cell - metabolism ; Carcinoma, Renal Cell - pathology ; Female ; Hematology ; Humans ; Internal Medicine ; Kidney - blood supply ; Kidney - pathology ; Kidney Neoplasms - metabolism ; Kidney Neoplasms - pathology ; Lipopolysaccharide Receptors - metabolism ; Lymphatic Metastasis ; Male ; Medicine ; Medicine & Public Health ; Middle Aged ; Monocytes - metabolism ; Monocytes - pathology ; Neovascularization, Pathologic ; Oncology ; Original Paper ; Pathology</subject><ispartof>Medical oncology (Northwood, London, England), 2014-12, Vol.31 (12), p.349-349, Article 349</ispartof><rights>Springer Science+Business Media New York 2014</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c414t-8d8a12feec1bc3a6a059eb362e24def983580b3735750975317f410f408ac3593</citedby><cites>FETCH-LOGICAL-c414t-8d8a12feec1bc3a6a059eb362e24def983580b3735750975317f410f408ac3593</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s12032-014-0349-1$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s12032-014-0349-1$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25416051$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Li, Miao</creatorcontrib><creatorcontrib>Zhang, Guangbo</creatorcontrib><creatorcontrib>Zhang, Xuefeng</creatorcontrib><creatorcontrib>Lv, Guanglin</creatorcontrib><creatorcontrib>Wei, Xuedong</creatorcontrib><creatorcontrib>Yuan, Hexing</creatorcontrib><creatorcontrib>Hou, Jianquan</creatorcontrib><title>Overexpression of B7-H3 in CD14+ monocytes is associated with renal cell carcinoma progression</title><title>Medical oncology (Northwood, London, England)</title><addtitle>Med Oncol</addtitle><addtitle>Med Oncol</addtitle><description>Renal cell carcinoma (RCC) is well known as a typical hypervascular tumor and has a high mortality rate. Tumor-induced angiogenesis is crucial for tumor growth and metastasis. It also plays an important role in the development and progression of RCC. However, the molecular mechanism is still unclear. In our study, we evaluated the expression level of B7-H3 in CD14
+
monocytes in 56 paired RCC samples and distant normal tissues by flow cytometry and located the co-expression of B7-H3 and CD14 by immunohistochemistry. In addition, we analyzed its association with clinical pathologic features through Chi-square test and Fisher exact test. Results showed that B7-H3 and CD14 co-expressed in tumor stroma surrounding the vessels and that the level of B7-H3 expression was higher in tumor than in normal tissues (63.42 ± 11.92 vs. 15.59 ± 3.01,
P
< 0.0001). Furthermore, the expression level was significantly associated with RCC stage (
P
= 0.000), nodal metastasis (
P
= 0.003), distant metastasis (
P
= 0.020), and nuclear grade (
P
= 0.004). Conclusively, we found the phenomenon that B7-H3 and CD14 co-expressed in RCC tissues. The level of expression was closely associated with the tumor’s progression, indicating that B7-H3 might play an important role in angiogenesis of RCC mediated by CD14
+
monocytes.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>B7 Antigens - metabolism</subject><subject>Carcinoma, Renal Cell - metabolism</subject><subject>Carcinoma, Renal Cell - pathology</subject><subject>Female</subject><subject>Hematology</subject><subject>Humans</subject><subject>Internal Medicine</subject><subject>Kidney - blood supply</subject><subject>Kidney - pathology</subject><subject>Kidney Neoplasms - metabolism</subject><subject>Kidney Neoplasms - pathology</subject><subject>Lipopolysaccharide Receptors - metabolism</subject><subject>Lymphatic Metastasis</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Monocytes - metabolism</subject><subject>Monocytes - pathology</subject><subject>Neovascularization, Pathologic</subject><subject>Oncology</subject><subject>Original Paper</subject><subject>Pathology</subject><issn>1357-0560</issn><issn>1559-131X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1PG0EMhkdVUUNpf0Av1RwrVVvs-diPI4RSkCJxAYlTR5OJl26U3QnjDZB_z0RJOXKxLfn1a_sR4hvCLwSoThkVaFUAmgK0aQr8II7R2lxovP-Ya22rAmwJE_GZeQmg0Krmk5goa7AEi8fi780TJXpZJ2Lu4iBjK8-r4krLbpDTCzQ_ZR-HGLYjsexYeuYYOj_SQj534z-ZaPArGWiVg0-hG2Lv5TrFh4PfF3HU-hXT10M-EXeXv2-nV8Xs5s_19GxWBINmLOpF7VG1RAHnQfvSg21orktFyiyobWpta5jrKv9joamsxqo1CK2B2gdtG30ifux98-7HDfHo-o53Z_mB4oYdlqpqLIKusxT30pAic6LWrVPX-7R1CG6H1e2xuozV7bA6zDPfD_abeU-Lt4n_HLNA7QWcW8MDJbeMm5TZ8DuurxrrgUk</recordid><startdate>20141201</startdate><enddate>20141201</enddate><creator>Li, Miao</creator><creator>Zhang, Guangbo</creator><creator>Zhang, Xuefeng</creator><creator>Lv, Guanglin</creator><creator>Wei, Xuedong</creator><creator>Yuan, Hexing</creator><creator>Hou, Jianquan</creator><general>Springer US</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20141201</creationdate><title>Overexpression of B7-H3 in CD14+ monocytes is associated with renal cell carcinoma progression</title><author>Li, Miao ; Zhang, Guangbo ; Zhang, Xuefeng ; Lv, Guanglin ; Wei, Xuedong ; Yuan, Hexing ; Hou, Jianquan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c414t-8d8a12feec1bc3a6a059eb362e24def983580b3735750975317f410f408ac3593</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>B7 Antigens - metabolism</topic><topic>Carcinoma, Renal Cell - metabolism</topic><topic>Carcinoma, Renal Cell - pathology</topic><topic>Female</topic><topic>Hematology</topic><topic>Humans</topic><topic>Internal Medicine</topic><topic>Kidney - blood supply</topic><topic>Kidney - pathology</topic><topic>Kidney Neoplasms - metabolism</topic><topic>Kidney Neoplasms - pathology</topic><topic>Lipopolysaccharide Receptors - metabolism</topic><topic>Lymphatic Metastasis</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Monocytes - metabolism</topic><topic>Monocytes - pathology</topic><topic>Neovascularization, Pathologic</topic><topic>Oncology</topic><topic>Original Paper</topic><topic>Pathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Li, Miao</creatorcontrib><creatorcontrib>Zhang, Guangbo</creatorcontrib><creatorcontrib>Zhang, Xuefeng</creatorcontrib><creatorcontrib>Lv, Guanglin</creatorcontrib><creatorcontrib>Wei, Xuedong</creatorcontrib><creatorcontrib>Yuan, Hexing</creatorcontrib><creatorcontrib>Hou, Jianquan</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Medical oncology (Northwood, London, England)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Li, Miao</au><au>Zhang, Guangbo</au><au>Zhang, Xuefeng</au><au>Lv, Guanglin</au><au>Wei, Xuedong</au><au>Yuan, Hexing</au><au>Hou, Jianquan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Overexpression of B7-H3 in CD14+ monocytes is associated with renal cell carcinoma progression</atitle><jtitle>Medical oncology (Northwood, London, England)</jtitle><stitle>Med Oncol</stitle><addtitle>Med Oncol</addtitle><date>2014-12-01</date><risdate>2014</risdate><volume>31</volume><issue>12</issue><spage>349</spage><epage>349</epage><pages>349-349</pages><artnum>349</artnum><issn>1357-0560</issn><eissn>1559-131X</eissn><abstract>Renal cell carcinoma (RCC) is well known as a typical hypervascular tumor and has a high mortality rate. Tumor-induced angiogenesis is crucial for tumor growth and metastasis. It also plays an important role in the development and progression of RCC. However, the molecular mechanism is still unclear. In our study, we evaluated the expression level of B7-H3 in CD14
+
monocytes in 56 paired RCC samples and distant normal tissues by flow cytometry and located the co-expression of B7-H3 and CD14 by immunohistochemistry. In addition, we analyzed its association with clinical pathologic features through Chi-square test and Fisher exact test. Results showed that B7-H3 and CD14 co-expressed in tumor stroma surrounding the vessels and that the level of B7-H3 expression was higher in tumor than in normal tissues (63.42 ± 11.92 vs. 15.59 ± 3.01,
P
< 0.0001). Furthermore, the expression level was significantly associated with RCC stage (
P
= 0.000), nodal metastasis (
P
= 0.003), distant metastasis (
P
= 0.020), and nuclear grade (
P
= 0.004). Conclusively, we found the phenomenon that B7-H3 and CD14 co-expressed in RCC tissues. The level of expression was closely associated with the tumor’s progression, indicating that B7-H3 might play an important role in angiogenesis of RCC mediated by CD14
+
monocytes.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>25416051</pmid><doi>10.1007/s12032-014-0349-1</doi><tpages>1</tpages></addata></record> |
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| ispartof | Medical oncology (Northwood, London, England), 2014-12, Vol.31 (12), p.349-349, Article 349 |
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| subjects | Adult Aged Aged, 80 and over B7 Antigens - metabolism Carcinoma, Renal Cell - metabolism Carcinoma, Renal Cell - pathology Female Hematology Humans Internal Medicine Kidney - blood supply Kidney - pathology Kidney Neoplasms - metabolism Kidney Neoplasms - pathology Lipopolysaccharide Receptors - metabolism Lymphatic Metastasis Male Medicine Medicine & Public Health Middle Aged Monocytes - metabolism Monocytes - pathology Neovascularization, Pathologic Oncology Original Paper Pathology |
| title | Overexpression of B7-H3 in CD14+ monocytes is associated with renal cell carcinoma progression |
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