Disruption of the blood–brain barrier exacerbates spreading depression in the locust CNS

[Display omitted] •We disrupted the locust blood–brain barrier (BBB) by transient exposure to 3M urea.•Urea pre-treatment increased the severity of ouabain-induced spreading depression.•The propagation rate of spreading depression was faster following urea treatment.•Following disruption of the BBB...

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Veröffentlicht in:	Journal of insect physiology 2014-07, Vol.66, p.1-9
Hauptverfasser:	Spong, Kristin E., Rochon-Terry, Geneviève, Money, Tomas G.A., Meldrum Robertson, R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Blood-Brain Barrier - drug effects Blood–brain barrier Central Nervous System - physiopathology Evoked Potentials - drug effects Glia Homeostasis - drug effects Ionic homeostasis Ions - metabolism Locust Locusta migratoria Locusta migratoria - physiology Male Ouabain - pharmacology Potassium Potassium - metabolism Spreading depression Stress, Physiological - drug effects Urea - pharmacology
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