Effects of Lactobacillus rhamnosus on allergic march model by suppressing Th2, Th17, and TSLP responses via CD4+ CD25+ Foxp3+ Tregs

Abstract Allergic march (AM) is characterized by the progression of clinical signs of atopic dermatitis (AD) to allergic asthma or rhinitis, but its pathogenesis is not completely understood. We developed mouse model of AM with three 1-week exposures (separated by 2-week interval) to an OVA or salin...

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Veröffentlicht in:	Clinical immunology (Orlando, Fla.) Fla.), 2014-07, Vol.153 (1), p.178-186
Hauptverfasser:	Kim, Ha-Jung, Kim, Young-Joon, Lee, Seung-Hwa, Yu, Jinho, Jeong, Se Kyoo, Hong, Soo-Jong
Format:	Artikel
Sprache:	eng
Schlagworte:	Allergic march Allergy and Immunology Animals Asthma - immunology Asthma - metabolism Asthma - pathology Cytokines - immunology Cytokines - metabolism Dermatitis, Atopic - immunology Dermatitis, Atopic - metabolism Disease Models, Animal Female Forkhead Transcription Factors - metabolism Interleukin-17 - metabolism Interleukin-2 Receptor alpha Subunit - metabolism Interleukin-4 - metabolism Lactobacillus rhamnosus Lactobacillus rhamnosus - immunology Lymph Nodes - immunology Lymph Nodes - metabolism Mesentery Mice Neutrophils - immunology Probiotics Probiotics - administration & dosage Regulatory T cells Skin - immunology Skin - metabolism T-Lymphocytes, Regulatory - immunology T-Lymphocytes, Regulatory - metabolism Th17 Th17 Cells - immunology Th17 Cells - metabolism Th2 Cells - immunology Th2 Cells - metabolism Thymic stromal lymphopoietin
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