Sodium arsenite induces ROS-dependent autophagic cell death in pancreatic β-cells

•Sodium arsenite increased autophagosome formation in INS-1 cells.•Sodium arsenite induced autophagic cell death in INS-1 cells.•Intracellular ROS played a vital role in the arsenite-induced autophagic cell death. Inorganic arsenic is a worldwide environmental pollutant. Inorganic arsenic’s positive...

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Veröffentlicht in:	Food and chemical toxicology 2014-08, Vol.70, p.144-150
Hauptverfasser:	Zhu, Xue-Xin, Yao, Xiao-Feng, Jiang, Li-Ping, Geng, Cheng-Yan, Zhong, Lai-Fu, Yang, Guang, Zheng, Bai-Lu, Sun, Xian-Ce
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Arsenites - toxicity Autophagy Autophagy - drug effects Biological and medical sciences Cell Line Cell Survival - drug effects Chemical and industrial products toxicology. Toxic occupational diseases Diabetes Mellitus, Type 2 - chemically induced Diabetes Mellitus, Type 2 - pathology Food toxicology INS-1 cell Insulin-Secreting Cells - drug effects Medical sciences Metals and various inorganic compounds Rats Reactive oxygen species Reactive Oxygen Species - metabolism Sodium arsenite Sodium Compounds - toxicity Toxicology
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