Circulating progenitor cells: a comparison of patients with glioblastoma or meningioma
Blood circulating endothelial cells and circulating hematopoietic progenitor cells (CPCs) are two cell populations that are thought to play important role in angiogenesis. In the present study, we investigated the role of CPCs in patients with brain tumors. We prospectively studied 19 brain tumor pa...
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| Veröffentlicht in: | Acta neurologica Belgica 2013-03, Vol.113 (1), p.7-11 |
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| container_title | Acta neurologica Belgica |
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| creator | Alexiou, George A. Vartholomatos, George Karamoutsios, Achilleas Batistatou, Anna Kyritsis, Athanasios P. Voulgaris, Spyridon |
| description | Blood circulating endothelial cells and circulating hematopoietic progenitor cells (CPCs) are two cell populations that are thought to play important role in angiogenesis. In the present study, we investigated the role of CPCs in patients with brain tumors. We prospectively studied 19 brain tumor patients. Ten healthy individuals were used as controls. Variables that were analyzed included age, sex, Ki-67 index, symptom duration, tumor location, tumor size and preoperative Karnofsky performance status score (KPS). CPCs were determined as CD45
dim
/CD34+/CD133+ in the peripheral blood. Twelve patients had glioblastoma (GBM), 1 patient had a grade II glioma and 6 patients had meningioma. Brain tumor patients had significantly higher CPC levels compared to healthy volunteers. Patients with gliomas had significantly higher CPC levels than patients with meningiomas. In GBM patients no correlation was found between CPC levels and sex, age, Ki-67 index, tumor location, size and KPS. Patients with CPC levels lower than 1,743 cells/ml had a higher progression-free survival but the difference was not statistically significant. Glioma patients had higher CPC levels compared to patients with meningiomas. Larger studies are obviously needed to verify the role of CPC levels in patients with brain tumors. |
| doi_str_mv | 10.1007/s13760-012-0097-y |
| format | Article |
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dim
/CD34+/CD133+ in the peripheral blood. Twelve patients had glioblastoma (GBM), 1 patient had a grade II glioma and 6 patients had meningioma. Brain tumor patients had significantly higher CPC levels compared to healthy volunteers. Patients with gliomas had significantly higher CPC levels than patients with meningiomas. In GBM patients no correlation was found between CPC levels and sex, age, Ki-67 index, tumor location, size and KPS. Patients with CPC levels lower than 1,743 cells/ml had a higher progression-free survival but the difference was not statistically significant. Glioma patients had higher CPC levels compared to patients with meningiomas. Larger studies are obviously needed to verify the role of CPC levels in patients with brain tumors.</description><identifier>ISSN: 0300-9009</identifier><identifier>EISSN: 2240-2993</identifier><identifier>DOI: 10.1007/s13760-012-0097-y</identifier><identifier>PMID: 22688590</identifier><language>eng</language><publisher>Milan: Springer Milan</publisher><subject>Adult ; Aged ; Biomedical and Life Sciences ; Biomedicine ; Brain Neoplasms - blood ; Brain Neoplasms - pathology ; Disease-Free Survival ; Female ; Glioblastoma - blood ; Glioblastoma - pathology ; Hematopoietic Stem Cells - pathology ; Humans ; Magnetic Resonance Imaging ; Male ; Medicine/Public Health ; Meningeal Neoplasms - blood ; Meningeal Neoplasms - pathology ; Meningioma - blood ; Meningioma - pathology ; Middle Aged ; Neovascularization, Pathologic - blood ; Neovascularization, Pathologic - pathology ; Neurology ; Neuroradiology ; Neurosciences ; Original Article ; Prospective Studies</subject><ispartof>Acta neurologica Belgica, 2013-03, Vol.113 (1), p.7-11</ispartof><rights>Belgian Neurological Society 2012</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c377t-fe28fffa38ced57e48120d16255a43b7eebfe82df650dfca2fa52c6f0aa29923</citedby><cites>FETCH-LOGICAL-c377t-fe28fffa38ced57e48120d16255a43b7eebfe82df650dfca2fa52c6f0aa29923</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s13760-012-0097-y$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s13760-012-0097-y$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>315,781,785,27926,27927,41490,42559,51321</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22688590$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Alexiou, George A.</creatorcontrib><creatorcontrib>Vartholomatos, George</creatorcontrib><creatorcontrib>Karamoutsios, Achilleas</creatorcontrib><creatorcontrib>Batistatou, Anna</creatorcontrib><creatorcontrib>Kyritsis, Athanasios P.</creatorcontrib><creatorcontrib>Voulgaris, Spyridon</creatorcontrib><title>Circulating progenitor cells: a comparison of patients with glioblastoma or meningioma</title><title>Acta neurologica Belgica</title><addtitle>Acta Neurol Belg</addtitle><addtitle>Acta Neurol Belg</addtitle><description>Blood circulating endothelial cells and circulating hematopoietic progenitor cells (CPCs) are two cell populations that are thought to play important role in angiogenesis. In the present study, we investigated the role of CPCs in patients with brain tumors. We prospectively studied 19 brain tumor patients. Ten healthy individuals were used as controls. Variables that were analyzed included age, sex, Ki-67 index, symptom duration, tumor location, tumor size and preoperative Karnofsky performance status score (KPS). CPCs were determined as CD45
dim
/CD34+/CD133+ in the peripheral blood. Twelve patients had glioblastoma (GBM), 1 patient had a grade II glioma and 6 patients had meningioma. Brain tumor patients had significantly higher CPC levels compared to healthy volunteers. Patients with gliomas had significantly higher CPC levels than patients with meningiomas. In GBM patients no correlation was found between CPC levels and sex, age, Ki-67 index, tumor location, size and KPS. Patients with CPC levels lower than 1,743 cells/ml had a higher progression-free survival but the difference was not statistically significant. Glioma patients had higher CPC levels compared to patients with meningiomas. Larger studies are obviously needed to verify the role of CPC levels in patients with brain tumors.</description><subject>Adult</subject><subject>Aged</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Brain Neoplasms - blood</subject><subject>Brain Neoplasms - pathology</subject><subject>Disease-Free Survival</subject><subject>Female</subject><subject>Glioblastoma - blood</subject><subject>Glioblastoma - pathology</subject><subject>Hematopoietic Stem Cells - pathology</subject><subject>Humans</subject><subject>Magnetic Resonance Imaging</subject><subject>Male</subject><subject>Medicine/Public Health</subject><subject>Meningeal Neoplasms - blood</subject><subject>Meningeal Neoplasms - pathology</subject><subject>Meningioma - blood</subject><subject>Meningioma - pathology</subject><subject>Middle Aged</subject><subject>Neovascularization, Pathologic - blood</subject><subject>Neovascularization, Pathologic - pathology</subject><subject>Neurology</subject><subject>Neuroradiology</subject><subject>Neurosciences</subject><subject>Original Article</subject><subject>Prospective Studies</subject><issn>0300-9009</issn><issn>2240-2993</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkM1KxDAURoMozjDOA7iRLN1Eb5K2ad3J4B8MuBnchrRNaoa2GZMWmbc3pepSswnhnu_j5iB0SeGGAojbQLnIgABlBKAQ5HiClowlQFhR8FO0BA5AijhaoHUIe4gnyRgV2TlaMJbleVrAEr1trK_GVg22b_DBu0b3dnAeV7ptwx1WuHLdQXkbXI-dwYcI6n4I-NMO77hprStbFQbXKRxDXQz3jY2vC3RmVBv0-vteod3jw27zTLavTy-b-y2puBADMZrlxhjF80rXqdBJThnUNGNpqhJeCq1Lo3NWmyyF2lSKGZWyKjOgVPwl4yt0PdfGzT9GHQbZ2TCtrnrtxiBjkyiSPJ7_UU5FHlE-tdIZrbwLwWsjD952yh8lBTm5l7N7Gd3Lyb08xszVd_1Ydrr-TfyYjgCbgRBHfaO93LvR91HOH61fBISQ8g</recordid><startdate>20130301</startdate><enddate>20130301</enddate><creator>Alexiou, George A.</creator><creator>Vartholomatos, George</creator><creator>Karamoutsios, Achilleas</creator><creator>Batistatou, Anna</creator><creator>Kyritsis, Athanasios P.</creator><creator>Voulgaris, Spyridon</creator><general>Springer Milan</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7TK</scope></search><sort><creationdate>20130301</creationdate><title>Circulating progenitor cells: a comparison of patients with glioblastoma or meningioma</title><author>Alexiou, George A. ; Vartholomatos, George ; Karamoutsios, Achilleas ; Batistatou, Anna ; Kyritsis, Athanasios P. ; Voulgaris, Spyridon</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c377t-fe28fffa38ced57e48120d16255a43b7eebfe82df650dfca2fa52c6f0aa29923</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Brain Neoplasms - blood</topic><topic>Brain Neoplasms - pathology</topic><topic>Disease-Free Survival</topic><topic>Female</topic><topic>Glioblastoma - blood</topic><topic>Glioblastoma - pathology</topic><topic>Hematopoietic Stem Cells - pathology</topic><topic>Humans</topic><topic>Magnetic Resonance Imaging</topic><topic>Male</topic><topic>Medicine/Public Health</topic><topic>Meningeal Neoplasms - blood</topic><topic>Meningeal Neoplasms - pathology</topic><topic>Meningioma - blood</topic><topic>Meningioma - pathology</topic><topic>Middle Aged</topic><topic>Neovascularization, Pathologic - blood</topic><topic>Neovascularization, Pathologic - pathology</topic><topic>Neurology</topic><topic>Neuroradiology</topic><topic>Neurosciences</topic><topic>Original Article</topic><topic>Prospective Studies</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Alexiou, George A.</creatorcontrib><creatorcontrib>Vartholomatos, George</creatorcontrib><creatorcontrib>Karamoutsios, Achilleas</creatorcontrib><creatorcontrib>Batistatou, Anna</creatorcontrib><creatorcontrib>Kyritsis, Athanasios P.</creatorcontrib><creatorcontrib>Voulgaris, Spyridon</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Neurosciences Abstracts</collection><jtitle>Acta neurologica Belgica</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Alexiou, George A.</au><au>Vartholomatos, George</au><au>Karamoutsios, Achilleas</au><au>Batistatou, Anna</au><au>Kyritsis, Athanasios P.</au><au>Voulgaris, Spyridon</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Circulating progenitor cells: a comparison of patients with glioblastoma or meningioma</atitle><jtitle>Acta neurologica Belgica</jtitle><stitle>Acta Neurol Belg</stitle><addtitle>Acta Neurol Belg</addtitle><date>2013-03-01</date><risdate>2013</risdate><volume>113</volume><issue>1</issue><spage>7</spage><epage>11</epage><pages>7-11</pages><issn>0300-9009</issn><eissn>2240-2993</eissn><abstract>Blood circulating endothelial cells and circulating hematopoietic progenitor cells (CPCs) are two cell populations that are thought to play important role in angiogenesis. In the present study, we investigated the role of CPCs in patients with brain tumors. We prospectively studied 19 brain tumor patients. Ten healthy individuals were used as controls. Variables that were analyzed included age, sex, Ki-67 index, symptom duration, tumor location, tumor size and preoperative Karnofsky performance status score (KPS). CPCs were determined as CD45
dim
/CD34+/CD133+ in the peripheral blood. Twelve patients had glioblastoma (GBM), 1 patient had a grade II glioma and 6 patients had meningioma. Brain tumor patients had significantly higher CPC levels compared to healthy volunteers. Patients with gliomas had significantly higher CPC levels than patients with meningiomas. In GBM patients no correlation was found between CPC levels and sex, age, Ki-67 index, tumor location, size and KPS. Patients with CPC levels lower than 1,743 cells/ml had a higher progression-free survival but the difference was not statistically significant. Glioma patients had higher CPC levels compared to patients with meningiomas. Larger studies are obviously needed to verify the role of CPC levels in patients with brain tumors.</abstract><cop>Milan</cop><pub>Springer Milan</pub><pmid>22688590</pmid><doi>10.1007/s13760-012-0097-y</doi><tpages>5</tpages></addata></record> |
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| subjects | Adult Aged Biomedical and Life Sciences Biomedicine Brain Neoplasms - blood Brain Neoplasms - pathology Disease-Free Survival Female Glioblastoma - blood Glioblastoma - pathology Hematopoietic Stem Cells - pathology Humans Magnetic Resonance Imaging Male Medicine/Public Health Meningeal Neoplasms - blood Meningeal Neoplasms - pathology Meningioma - blood Meningioma - pathology Middle Aged Neovascularization, Pathologic - blood Neovascularization, Pathologic - pathology Neurology Neuroradiology Neurosciences Original Article Prospective Studies |
| title | Circulating progenitor cells: a comparison of patients with glioblastoma or meningioma |
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