Protective Effects of Benidipine on Arachidonic Acid-Induced Acute Cerebral Ischemia in Rats

Acute cerebral ischemia was produced in rats by injection of arachidonic acid (AA) into the internal carotid artery. Evans blue (EB) was intravenously injected and its extravasation into the brain was determined as an indicator of disturbances in the blood-brain barrier and endothelial cells. Contro...

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Veröffentlicht in:	Japanese Journal of Pharmacology 1992, Vol.59(1), pp.15-22
Hauptverfasser:	Shirakura, Shiro, Sano, Jun-ichi, Karasawa, Akira, Kubo, Kazuhiro
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Arachidonic acid Arachidonic Acid - toxicity Atomic and molecular physics Benidipine Benzoquinones - pharmacology Blood-Brain Barrier - drug effects Brain Edema - prevention & control Brain Ischemia - chemically induced Brain Ischemia - drug therapy Calcium Channel Blockers - pharmacology Cerebral edema Cerebral Infarction - chemically induced Cerebral Infarction - drug therapy Cerebral ischemia (acute) Dihydropyridines - pharmacology Evans Blue - chemistry Exact sciences and technology Lipoxygenase Inhibitors - pharmacology Male Methacrylates - pharmacology Nicardipine Nicardipine - pharmacology Other special atoms, molecules, ions and clusters Physics Rats Rats, Inbred Strains Studies of special atoms, molecules and their ions clusters Thromboxane-A Synthase - antagonists & inhibitors Ticlopidine - pharmacology
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