Phosphatidylinositol 3-Kinase Mediates Chemoattractant-Stimulated, CD11b/CD18-Dependent Cell-Cell Adhesion of Human Neutrophils: Evidence for an ERK-Independent Pathway

We examined the role of phosphatidylinositol 3-kinase (PI 3-K) in FMLP-stimulated cell-cell adhesion of human neutrophils. The specific PI 3-K inhibitors wortmannin and LY294002 inhibited neutrophil homotypic aggregation stimulated by chemoattractants such as FMLP (50% inhibitory concentration (IC50...

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Veröffentlicht in:	The Journal of immunology (1950) 1998-02, Vol.160 (4), p.1901-1909
Hauptverfasser:	Capodici, Constance, Hanft, Simon, Feoktistov, Marianne, Pillinger, Michael H
Format:	Artikel
Sprache:	eng
Schlagworte:	Androstadienes - pharmacology Calcium-Calmodulin-Dependent Protein Kinases - antagonists & inhibitors Calcium-Calmodulin-Dependent Protein Kinases - physiology CD18 Antigens - biosynthesis CD18 Antigens - physiology Cell Adhesion - drug effects Cell Adhesion - immunology Cell Aggregation - drug effects Cell Aggregation - immunology Cell Line, Transformed Chromones - pharmacology Complement C5a - antagonists & inhibitors Complement C5a - physiology Endothelium, Vascular - drug effects Endothelium, Vascular - immunology Epitopes - biosynthesis Humans Ionophores - pharmacology Macrophage-1 Antigen - biosynthesis Macrophage-1 Antigen - physiology Morpholines - pharmacology Muramidase - antagonists & inhibitors Muramidase - metabolism N-Formylmethionine Leucyl-Phenylalanine - antagonists & inhibitors N-Formylmethionine Leucyl-Phenylalanine - pharmacology Neutrophil Activation - immunology Neutrophils - drug effects Neutrophils - enzymology Neutrophils - immunology Phosphatidylinositol 3-Kinases - physiology Tetradecanoylphorbol Acetate - pharmacology Up-Regulation - drug effects Up-Regulation - immunology
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