Antagonism of Immunostimulatory CpG-Oligodeoxynucleotides by Quinacrine, Chloroquine, and Structurally Related Compounds

Phosphorothioate oligodeoxynucleotides containing CpG (CpG-ODN) activate immune responses. We report that quinacrine, chloroquine, and structurally related compounds completely inhibit the antiapoptotic effect of CpG-ODN on WEHI 231 murine B lymphoma cells and inhibit CpG-ODN-induced secretion of IL...

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Veröffentlicht in:	The Journal of immunology (1950) 1998-02, Vol.160 (3), p.1122-1131
Hauptverfasser:	Macfarlane, Donald E, Manzel, Lori
Format:	Artikel
Sprache:	eng
Schlagworte:	Acids - antagonists & inhibitors Acids - metabolism Adjuvants, Immunologic - antagonists & inhibitors Adjuvants, Immunologic - physiology Animals Apoptosis - drug effects Apoptosis - immunology Binding, Competitive - immunology Biological Transport - drug effects Biological Transport - immunology Cell Division - drug effects Cell Division - immunology Cell Line Chloroquine - pharmacology CpG Islands - drug effects CpG Islands - immunology Drug Resistance, Multiple - immunology Humans Immunosuppressive Agents - pharmacology Intercalating Agents - pharmacology Interleukin-6 - biosynthesis Kinetics Leukocytes, Mononuclear - drug effects Lipopolysaccharides - pharmacology Mice Oligodeoxyribonucleotides - antagonists & inhibitors Oligodeoxyribonucleotides - immunology Oligodeoxyribonucleotides - metabolism Quinacrine - pharmacology Structure-Activity Relationship Thionucleotides - antagonists & inhibitors Thionucleotides - immunology Thionucleotides - metabolism
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