Effects of an Ethanol Extract of Brazilian Green Propolis on Human Cytochrome P450 Enzyme Activities in Vitro

Supplement–drug interaction on CYP enzyme activity is occasionally found to cause clinically adverse events, and no report on interactions of propolis is available either in vitro or clinical. In this study, we tried to estimate the risk of an interaction between an ethanol extract of Brazilian gree...

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Veröffentlicht in:	Journal of agricultural and food chemistry 2014-11, Vol.62 (46), p.11296-11302
Hauptverfasser:	Naramoto, Kyoko, Kato, Masashi, Ichihara, Kenji
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals blood Brazil cytochrome P-450 Cytochrome P-450 Enzyme Inhibitors - chemistry Cytochrome P-450 Enzyme Inhibitors - metabolism Cytochrome P-450 Enzyme System - chemistry Cytochrome P-450 Enzyme System - metabolism drugs enzyme activity ethanol Food-Drug Interactions Humans inhibitory concentration 50 kaempferol Kinetics liver Male propolis Propolis - chemistry Propolis - metabolism Rats Rats, Wistar risk estimate
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