Allelic Imbalance at an 8q24 Oncogenic SNP is Involved in Activating MYC in Human Colorectal Cancer

Background The rs6983267 at 8q24.21 has been established as a significant cancer-related single nucleotide polymorphism (SNP). The risk allele showed similarity to the binding site of transcription factor TCF4/LEF1 that activates transcription of MYC . However, little is known about the role of this...

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Veröffentlicht in:	Annals of surgical oncology 2014-12, Vol.21 (Suppl 4), p.515-521
Hauptverfasser:	Sugimachi, Keishi, Niida, Atsushi, Yamamoto, Ken, Shimamura, Teppei, Imoto, Seiya, Iinuma, Hisae, Shinden, Yoshiaki, Eguchi, Hidetoshi, Sudo, Tomoya, Watanabe, Masahiko, Tanaka, Junichi, Kudo, Shinei, Hase, Kazuo, Kusunoki, Masato, Yamada, Kazutaka, Shimada, Yasuhiro, Sugihara, Kenichi, Maehara, Yoshihiko, Miyano, Satoru, Mori, Masaki, Mimori, Koshi
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Alleles Cecal Neoplasms - genetics Cell Line, Tumor Chromosomes, Human, Pair 8 DNA Copy Number Variations Female Gene Amplification Gene Expression Genes, myc - genetics Genotype Humans Leukocytes, Mononuclear Loss of Heterozygosity Male Medicine Medicine & Public Health Middle Aged Oncology Polymorphism, Single Nucleotide Rectal Neoplasms - genetics Sigmoid Neoplasms - genetics Surgery Surgical Oncology Translational Research and Biomarkers
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