Metabolic profiling of synovial fluid in a unilateral ovine model of anterior cruciate ligament reconstruction of the knee suggests biomarkers for early osteoarthritis

ABSTRACT Joint injuries and subsequent osteoarthritis (OA) are the leading causes of chronic joint disease. In this work, we explore the possibility of applying magnetic resonance spectroscopy‐based metabolomics to detect host responses to an anterior cruciate ligament (ACL) reconstruction injury in...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Journal of orthopaedic research 2015-01, Vol.33 (1), p.71-77
Hauptverfasser:	Mickiewicz, Beata, Heard, Bryan J., Chau, Johnny K., Chung, May, Hart, David A., Shrive, Nigel G., Frank, Cyril B., Vogel, Hans J.
Format:	Artikel
Sprache:	eng
Schlagworte:	1H nuclear magnetic resonance spectroscopy Animals Anterior Cruciate Ligament Reconstruction Asparagine - metabolism Biomarkers - metabolism Disease Models, Animal Female Glucose - metabolism Hydroxyproline - metabolism Isobutyrates - metabolism knee injury Knee Joint - surgery Magnetic Resonance Spectroscopy Metabolome metabolomics osteoarthritis Osteoarthritis, Knee - diagnosis Osteoarthritis, Knee - metabolism Serine - metabolism Sheep synovial fluid Synovial Fluid - metabolism Uridine - metabolism
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!