Sperm typing allows accurate measurement of the recombination fraction between D3S2 and D3S3 on the short arm of human chromosome 3
The interval between the D3S2 and D3S3 loci on human chromosome 3p is a frequent site of deletions in a number of different cancers and contains the most common fragile site in man. Both loci have been physically mapped to 3p but because heterozygosity for D3S3 is so infrequent, recombination betwee...
Gespeichert in:
| Veröffentlicht in: | Genomics (San Diego, Calif.) Calif.), 1992-04, Vol.12 (4), p.683-687 |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 687 |
|---|---|
| container_issue | 4 |
| container_start_page | 683 |
| container_title | Genomics (San Diego, Calif.) |
| container_volume | 12 |
| creator | Hubert, Rene Stanton, Vincent P. Aburatani, Hiroyuki Warren, John Li, Honghua Housman, David E. Arnheim, Norman |
| description | The interval between the D3S2 and D3S3 loci on human chromosome 3p is a frequent site of deletions in a number of different cancers and contains the most common fragile site in man. Both loci have been physically mapped to 3p but because heterozygosity for D3S3 is so infrequent, recombination between them could not be determined accurately by using family studies. Sperm typing can measure recombination between DNA polymorphisms even in a single individual and thus can make use of polymorphisms with a low PIC. The recombination fraction between D3S2 and D3S3 was estimated to be 0.28 based on analyzing 189 and 77 sperm from two doubly heterozygous donors, respectively. These results demonstrate one of the ways in which sperm typing can complement pedigree analysis in constructing genetic maps. |
| doi_str_mv | 10.1016/0888-7543(92)90294-3 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_proquest_miscellaneous_16266665</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>0888754392902943</els_id><sourcerecordid>72923362</sourcerecordid><originalsourceid>FETCH-LOGICAL-c388t-f929f938b60fa308f39f5e8ae9ee52d4a7d95de8a37c0ceeba268aa11d26f6713</originalsourceid><addsrcrecordid>eNqNkUuPFCEUhStGM7aj_0ATVkZjSnlUUbCZZNI-RjOJi9E1oaiLXaaAFig7s_aPS3V1xp3KhhvuOYcLX1U9Jfg1wYS_wUKIumsb9kLSlxJT2dTsXrUhWMha8IbfrzZ3kofVo5S-Y4wlE_SsOiOskVTyTfXrZg_RoXy7H_03pKcpHBLSxsxRZ0AOdJojOPAZBYvyDlAEE1w_ep3H4JGN2hyLHvIBwKO37IYi7YelYKg0Fk_ahZiRLveUkN3stEdmF4MLKThA7HH1wOopwZPTfl59ff_uy_aqvv784eP28ro2TIhc2zKxLfP3HFvNsLBM2haEBgnQ0qHR3SDboRywzmAD0GvKhdaEDJRb3hF2Xj1fc_cx_JghZeXGZGCatIcwJ9VRSRnj9J9Cwikvqy3CZhWaGFKKYNU-jk7HW0WwWiCphYBaCChJ1RGSYsX27JQ_9w6GP6aVSumLtX-APthkRvAG7lSXREp69antmsKT4O2Yjyy2Yfa5WF_9v7WoL1Y1lG__OUJUJ8cwFs5ZDWH8-0t-A-XFw2g</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>16266665</pqid></control><display><type>article</type><title>Sperm typing allows accurate measurement of the recombination fraction between D3S2 and D3S3 on the short arm of human chromosome 3</title><source>Web of Science - Science Citation Index Expanded - 1992<img src="https://exlibris-pub.s3.amazonaws.com/fromwos-v2.jpg" /></source><source>MEDLINE</source><source>Elsevier ScienceDirect Journals Complete</source><creator>Hubert, Rene ; Stanton, Vincent P. ; Aburatani, Hiroyuki ; Warren, John ; Li, Honghua ; Housman, David E. ; Arnheim, Norman</creator><creatorcontrib>Hubert, Rene ; Stanton, Vincent P. ; Aburatani, Hiroyuki ; Warren, John ; Li, Honghua ; Housman, David E. ; Arnheim, Norman</creatorcontrib><description>The interval between the D3S2 and D3S3 loci on human chromosome 3p is a frequent site of deletions in a number of different cancers and contains the most common fragile site in man. Both loci have been physically mapped to 3p but because heterozygosity for D3S3 is so infrequent, recombination between them could not be determined accurately by using family studies. Sperm typing can measure recombination between DNA polymorphisms even in a single individual and thus can make use of polymorphisms with a low PIC. The recombination fraction between D3S2 and D3S3 was estimated to be 0.28 based on analyzing 189 and 77 sperm from two doubly heterozygous donors, respectively. These results demonstrate one of the ways in which sperm typing can complement pedigree analysis in constructing genetic maps.</description><identifier>ISSN: 0888-7543</identifier><identifier>EISSN: 1089-8646</identifier><identifier>DOI: 10.1016/0888-7543(92)90294-3</identifier><identifier>PMID: 1349296</identifier><language>eng</language><publisher>SAN DIEGO: Elsevier Inc</publisher><subject>Base Sequence ; Biotechnology & Applied Microbiology ; chromosome 3 ; Chromosome Deletion ; Chromosome Fragile Sites ; Chromosome Fragility ; Chromosome Mapping ; Chromosomes, Human, Pair 3 ; D3S2 loci ; D3S3 loci ; DNA - genetics ; Genetics & Heredity ; Humans ; Life Sciences & Biomedicine ; loci ; Male ; man ; Molecular Sequence Data ; Neoplasms - genetics ; Polymerase Chain Reaction ; Polymorphism, Restriction Fragment Length ; recombination ; Recombination, Genetic ; Science & Technology ; spermatocytes ; Spermatozoa - ultrastructure ; typing</subject><ispartof>Genomics (San Diego, Calif.), 1992-04, Vol.12 (4), p.683-687</ispartof><rights>1992</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>true</woscitedreferencessubscribed><woscitedreferencescount>19</woscitedreferencescount><woscitedreferencesoriginalsourcerecordid>wosA1992HJ57400010</woscitedreferencesoriginalsourcerecordid><citedby>FETCH-LOGICAL-c388t-f929f938b60fa308f39f5e8ae9ee52d4a7d95de8a37c0ceeba268aa11d26f6713</citedby><cites>FETCH-LOGICAL-c388t-f929f938b60fa308f39f5e8ae9ee52d4a7d95de8a37c0ceeba268aa11d26f6713</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0888-7543(92)90294-3$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>315,781,785,3551,27197,27929,27930,46000</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1349296$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hubert, Rene</creatorcontrib><creatorcontrib>Stanton, Vincent P.</creatorcontrib><creatorcontrib>Aburatani, Hiroyuki</creatorcontrib><creatorcontrib>Warren, John</creatorcontrib><creatorcontrib>Li, Honghua</creatorcontrib><creatorcontrib>Housman, David E.</creatorcontrib><creatorcontrib>Arnheim, Norman</creatorcontrib><title>Sperm typing allows accurate measurement of the recombination fraction between D3S2 and D3S3 on the short arm of human chromosome 3</title><title>Genomics (San Diego, Calif.)</title><addtitle>GENOMICS</addtitle><addtitle>Genomics</addtitle><description>The interval between the D3S2 and D3S3 loci on human chromosome 3p is a frequent site of deletions in a number of different cancers and contains the most common fragile site in man. Both loci have been physically mapped to 3p but because heterozygosity for D3S3 is so infrequent, recombination between them could not be determined accurately by using family studies. Sperm typing can measure recombination between DNA polymorphisms even in a single individual and thus can make use of polymorphisms with a low PIC. The recombination fraction between D3S2 and D3S3 was estimated to be 0.28 based on analyzing 189 and 77 sperm from two doubly heterozygous donors, respectively. These results demonstrate one of the ways in which sperm typing can complement pedigree analysis in constructing genetic maps.</description><subject>Base Sequence</subject><subject>Biotechnology & Applied Microbiology</subject><subject>chromosome 3</subject><subject>Chromosome Deletion</subject><subject>Chromosome Fragile Sites</subject><subject>Chromosome Fragility</subject><subject>Chromosome Mapping</subject><subject>Chromosomes, Human, Pair 3</subject><subject>D3S2 loci</subject><subject>D3S3 loci</subject><subject>DNA - genetics</subject><subject>Genetics & Heredity</subject><subject>Humans</subject><subject>Life Sciences & Biomedicine</subject><subject>loci</subject><subject>Male</subject><subject>man</subject><subject>Molecular Sequence Data</subject><subject>Neoplasms - genetics</subject><subject>Polymerase Chain Reaction</subject><subject>Polymorphism, Restriction Fragment Length</subject><subject>recombination</subject><subject>Recombination, Genetic</subject><subject>Science & Technology</subject><subject>spermatocytes</subject><subject>Spermatozoa - ultrastructure</subject><subject>typing</subject><issn>0888-7543</issn><issn>1089-8646</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1992</creationdate><recordtype>article</recordtype><sourceid>EZCTM</sourceid><sourceid>EIF</sourceid><recordid>eNqNkUuPFCEUhStGM7aj_0ATVkZjSnlUUbCZZNI-RjOJi9E1oaiLXaaAFig7s_aPS3V1xp3KhhvuOYcLX1U9Jfg1wYS_wUKIumsb9kLSlxJT2dTsXrUhWMha8IbfrzZ3kofVo5S-Y4wlE_SsOiOskVTyTfXrZg_RoXy7H_03pKcpHBLSxsxRZ0AOdJojOPAZBYvyDlAEE1w_ep3H4JGN2hyLHvIBwKO37IYi7YelYKg0Fk_ahZiRLveUkN3stEdmF4MLKThA7HH1wOopwZPTfl59ff_uy_aqvv784eP28ro2TIhc2zKxLfP3HFvNsLBM2haEBgnQ0qHR3SDboRywzmAD0GvKhdaEDJRb3hF2Xj1fc_cx_JghZeXGZGCatIcwJ9VRSRnj9J9Cwikvqy3CZhWaGFKKYNU-jk7HW0WwWiCphYBaCChJ1RGSYsX27JQ_9w6GP6aVSumLtX-APthkRvAG7lSXREp69antmsKT4O2Yjyy2Yfa5WF_9v7WoL1Y1lG__OUJUJ8cwFs5ZDWH8-0t-A-XFw2g</recordid><startdate>19920401</startdate><enddate>19920401</enddate><creator>Hubert, Rene</creator><creator>Stanton, Vincent P.</creator><creator>Aburatani, Hiroyuki</creator><creator>Warren, John</creator><creator>Li, Honghua</creator><creator>Housman, David E.</creator><creator>Arnheim, Norman</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>BLEPL</scope><scope>DTL</scope><scope>EZCTM</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T3</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>19920401</creationdate><title>Sperm typing allows accurate measurement of the recombination fraction between D3S2 and D3S3 on the short arm of human chromosome 3</title><author>Hubert, Rene ; Stanton, Vincent P. ; Aburatani, Hiroyuki ; Warren, John ; Li, Honghua ; Housman, David E. ; Arnheim, Norman</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c388t-f929f938b60fa308f39f5e8ae9ee52d4a7d95de8a37c0ceeba268aa11d26f6713</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1992</creationdate><topic>Base Sequence</topic><topic>Biotechnology & Applied Microbiology</topic><topic>chromosome 3</topic><topic>Chromosome Deletion</topic><topic>Chromosome Fragile Sites</topic><topic>Chromosome Fragility</topic><topic>Chromosome Mapping</topic><topic>Chromosomes, Human, Pair 3</topic><topic>D3S2 loci</topic><topic>D3S3 loci</topic><topic>DNA - genetics</topic><topic>Genetics & Heredity</topic><topic>Humans</topic><topic>Life Sciences & Biomedicine</topic><topic>loci</topic><topic>Male</topic><topic>man</topic><topic>Molecular Sequence Data</topic><topic>Neoplasms - genetics</topic><topic>Polymerase Chain Reaction</topic><topic>Polymorphism, Restriction Fragment Length</topic><topic>recombination</topic><topic>Recombination, Genetic</topic><topic>Science & Technology</topic><topic>spermatocytes</topic><topic>Spermatozoa - ultrastructure</topic><topic>typing</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hubert, Rene</creatorcontrib><creatorcontrib>Stanton, Vincent P.</creatorcontrib><creatorcontrib>Aburatani, Hiroyuki</creatorcontrib><creatorcontrib>Warren, John</creatorcontrib><creatorcontrib>Li, Honghua</creatorcontrib><creatorcontrib>Housman, David E.</creatorcontrib><creatorcontrib>Arnheim, Norman</creatorcontrib><collection>Web of Science Core Collection</collection><collection>Science Citation Index Expanded</collection><collection>Web of Science - Science Citation Index Expanded - 1992</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Human Genome Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Genomics (San Diego, Calif.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hubert, Rene</au><au>Stanton, Vincent P.</au><au>Aburatani, Hiroyuki</au><au>Warren, John</au><au>Li, Honghua</au><au>Housman, David E.</au><au>Arnheim, Norman</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Sperm typing allows accurate measurement of the recombination fraction between D3S2 and D3S3 on the short arm of human chromosome 3</atitle><jtitle>Genomics (San Diego, Calif.)</jtitle><stitle>GENOMICS</stitle><addtitle>Genomics</addtitle><date>1992-04-01</date><risdate>1992</risdate><volume>12</volume><issue>4</issue><spage>683</spage><epage>687</epage><pages>683-687</pages><issn>0888-7543</issn><eissn>1089-8646</eissn><abstract>The interval between the D3S2 and D3S3 loci on human chromosome 3p is a frequent site of deletions in a number of different cancers and contains the most common fragile site in man. Both loci have been physically mapped to 3p but because heterozygosity for D3S3 is so infrequent, recombination between them could not be determined accurately by using family studies. Sperm typing can measure recombination between DNA polymorphisms even in a single individual and thus can make use of polymorphisms with a low PIC. The recombination fraction between D3S2 and D3S3 was estimated to be 0.28 based on analyzing 189 and 77 sperm from two doubly heterozygous donors, respectively. These results demonstrate one of the ways in which sperm typing can complement pedigree analysis in constructing genetic maps.</abstract><cop>SAN DIEGO</cop><pub>Elsevier Inc</pub><pmid>1349296</pmid><doi>10.1016/0888-7543(92)90294-3</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0888-7543 |
| ispartof | Genomics (San Diego, Calif.), 1992-04, Vol.12 (4), p.683-687 |
| issn | 0888-7543 1089-8646 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_16266665 |
| source | Web of Science - Science Citation Index Expanded - 1992<img src="https://exlibris-pub.s3.amazonaws.com/fromwos-v2.jpg" />; MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Base Sequence Biotechnology & Applied Microbiology chromosome 3 Chromosome Deletion Chromosome Fragile Sites Chromosome Fragility Chromosome Mapping Chromosomes, Human, Pair 3 D3S2 loci D3S3 loci DNA - genetics Genetics & Heredity Humans Life Sciences & Biomedicine loci Male man Molecular Sequence Data Neoplasms - genetics Polymerase Chain Reaction Polymorphism, Restriction Fragment Length recombination Recombination, Genetic Science & Technology spermatocytes Spermatozoa - ultrastructure typing |
| title | Sperm typing allows accurate measurement of the recombination fraction between D3S2 and D3S3 on the short arm of human chromosome 3 |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-13T22%3A02%3A48IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Sperm%20typing%20allows%20accurate%20measurement%20of%20the%20recombination%20fraction%20between%20D3S2%20and%20D3S3%20on%20the%20short%20arm%20of%20human%20chromosome%203&rft.jtitle=Genomics%20(San%20Diego,%20Calif.)&rft.au=Hubert,%20Rene&rft.date=1992-04-01&rft.volume=12&rft.issue=4&rft.spage=683&rft.epage=687&rft.pages=683-687&rft.issn=0888-7543&rft.eissn=1089-8646&rft_id=info:doi/10.1016/0888-7543(92)90294-3&rft_dat=%3Cproquest_pubme%3E72923362%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=16266665&rft_id=info:pmid/1349296&rft_els_id=0888754392902943&rfr_iscdi=true |