3-Methylindole-induced splenotoxicity: Biochemical mechanisms of cytotoxicity

3-Methylindole (3-MI) is a pneumotoxic metabolite of l-tryptophan that can form in the digestive tracts of humans and ruminants as a result of microbial protein metabolism. Alternatively, human lungs can be directly exposed to 3-MI formed during protein pyrolysis and inhalation of tobacco smoke. 3-M...

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Veröffentlicht in:	Toxicology and applied pharmacology 1991-07, Vol.109 (3), p.375-390
Hauptverfasser:	Updyke, Lawrence W., Yoon, Hyunah L., Kiorpes, Anthony L., Robinson, J.Paul, Pfeifer, Richard W., Marcus, Craig B.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adrenalectomy Animals Biological and medical sciences Cell Survival - drug effects Cells, Cultured Injections, Intraperitoneal Male Medical sciences Mice Miscellaneous Organ Size - drug effects Rats Rats, Inbred Strains Skatole - toxicity Spleen - drug effects Spleen - pathology Toxicology
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