Skin cancer and chromosomal aberrations induced by ultraviolet radiation: Evidence for lack of correlation in xeroderma pigmentosum variant and group E patients

Ultraviolet radiation (UV) in sunlight induces an abnormally high incidence of skin cancer in patients with xeroderma pigmentosum (XP), an autosomal recessive disease with defects in the repair of damaged DNA. We determined the frequency of UV-induced chromosomal aberrations in cultured lymphoblast...

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Veröffentlicht in:	Cancer genetics and cytogenetics 1992-06, Vol.60 (2), p.111-116
Hauptverfasser:	Seguin, Lana R., Ganges, Mary B., Tarone, Robert E., Robbins, Jay H.
Format:	Artikel
Sprache:	eng
Schlagworte:	Caffeine - pharmacology cancer Cell Line, Transformed Chromosome Aberrations DNA Repair - drug effects DNA Repair - radiation effects Humans man Neoplasms, Radiation-Induced - genetics skin Skin Neoplasms - genetics U.V. radiation Ultraviolet Rays - adverse effects xeroderma pigmentosum Xeroderma Pigmentosum - genetics
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