Mechanisms of endothelial to mesenchymal transition in the retina in diabetes

Hyperglycemia-induced endothelial damage is a key pathogenetic factor in diabetic retinopathy. Endothelial damage may lead to phenotypic changes in the cells manifested by reduced expression of endothelial markers and increased expression of mesenchymal markers, termed endothelial to mesenchymal tra...

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Veröffentlicht in:	Investigative ophthalmology & visual science 2014-11, Vol.55 (11), p.7321-7331
Hauptverfasser:	Cao, Yanan, Feng, Biao, Chen, Shali, Chu, Yanhui, Chakrabarti, Subrata
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Blotting, Western Cells, Cultured Diabetes Mellitus, Experimental Diabetic Retinopathy - genetics Diabetic Retinopathy - metabolism Diabetic Retinopathy - pathology Down-Regulation E1A-Associated p300 Protein - biosynthesis E1A-Associated p300 Protein - genetics Endothelial Cells - metabolism Endothelial Cells - pathology Enzyme-Linked Immunosorbent Assay Humans Male Mice Mice, Inbred C57BL Mice, Transgenic MicroRNAs - biosynthesis MicroRNAs - genetics Retinal Ganglion Cells - metabolism Retinal Ganglion Cells - pathology Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - genetics
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