Causes of epidermal filaggrin reduction and their role in the pathogenesis of atopic dermatitis
The epidermis protects human subjects from exogenous stressors and helps to maintain internal fluid and electrolyte homeostasis. Filaggrin is a crucial epidermal protein that is important for the formation of the corneocyte, as well as the generation of its intracellular metabolites, which contribut...
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| Veröffentlicht in: | Journal of allergy and clinical immunology 2014-10, Vol.134 (4), p.792-799 |
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| creator | Thyssen, Jacob P., MD, PhD Kezic, Sanja, PhD |
| description | The epidermis protects human subjects from exogenous stressors and helps to maintain internal fluid and electrolyte homeostasis. Filaggrin is a crucial epidermal protein that is important for the formation of the corneocyte, as well as the generation of its intracellular metabolites, which contribute to stratum corneum hydration and pH. The levels of filaggrin and its degradation products are influenced not only by the filaggrin genotype but also by inflammation and exogenous stressors. Pertinently, filaggrin deficiency is observed in patients with atopic dermatitis regardless of filaggrin mutation status, suggesting that the absence of filaggrin is a key factor in the pathogenesis of this skin condition. In this article we review the various causes of low filaggrin levels, centralizing the functional and morphologic role of a deficiency in filaggrin, its metabolites, or both in the etiopathogenesis of atopic dermatitis. |
| doi_str_mv | 10.1016/j.jaci.2014.06.014 |
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Filaggrin is a crucial epidermal protein that is important for the formation of the corneocyte, as well as the generation of its intracellular metabolites, which contribute to stratum corneum hydration and pH. The levels of filaggrin and its degradation products are influenced not only by the filaggrin genotype but also by inflammation and exogenous stressors. Pertinently, filaggrin deficiency is observed in patients with atopic dermatitis regardless of filaggrin mutation status, suggesting that the absence of filaggrin is a key factor in the pathogenesis of this skin condition. In this article we review the various causes of low filaggrin levels, centralizing the functional and morphologic role of a deficiency in filaggrin, its metabolites, or both in the etiopathogenesis of atopic dermatitis.</description><identifier>ISSN: 0091-6749</identifier><identifier>EISSN: 1097-6825</identifier><identifier>DOI: 10.1016/j.jaci.2014.06.014</identifier><identifier>PMID: 25065719</identifier><identifier>CODEN: JACIBY</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Allergic diseases ; Allergy and Immunology ; Amino acids ; Animals ; Atopic dermatitis ; barrier function ; Biological and medical sciences ; Cell Membrane Permeability ; Cell Surface Extensions - metabolism ; Cell Surface Extensions - pathology ; Cytokines ; Cytokines - immunology ; Dermatitis, Atopic - genetics ; Dermatitis, Atopic - immunology ; Dermatology ; Down-Regulation ; Dyskeratosis ; Epidermis - immunology ; filaggrin ; Fundamental and applied biological sciences. Psychology ; Fundamental immunology ; Genetic Predisposition to Disease ; histidine ; Homeostasis ; Human subjects ; Humans ; Hydration ; ichthyosis vulgaris ; Immunopathology ; Intermediate Filament Proteins - deficiency ; Intermediate Filament Proteins - genetics ; lamellar body ; Lipid Metabolism ; Lipids ; Medical sciences ; Metabolites ; Mice ; Microorganisms ; Mutation ; Pathogenesis ; Proteins ; Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis ; Skin ; Skin allergic diseases. Stinging insect allergies ; stratum corneum ; Stress, Psychological - immunology ; Th2 Cells - immunology ; TH2 cytokines ; urocanic acid</subject><ispartof>Journal of allergy and clinical immunology, 2014-10, Vol.134 (4), p.792-799</ispartof><rights>American Academy of Allergy, Asthma & Immunology</rights><rights>2014 American Academy of Allergy, Asthma & Immunology</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2014 American Academy of Allergy, Asthma & Immunology. Published by Elsevier Inc. All rights reserved.</rights><rights>Copyright Elsevier Limited Oct 2014</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c535t-8dc116383543da6f255ffe767b0fd0dfa48ca2b12bd950ca1e7851fceec6d4353</citedby><cites>FETCH-LOGICAL-c535t-8dc116383543da6f255ffe767b0fd0dfa48ca2b12bd950ca1e7851fceec6d4353</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S009167491400863X$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=28887047$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25065719$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Thyssen, Jacob P., MD, PhD</creatorcontrib><creatorcontrib>Kezic, Sanja, PhD</creatorcontrib><title>Causes of epidermal filaggrin reduction and their role in the pathogenesis of atopic dermatitis</title><title>Journal of allergy and clinical immunology</title><addtitle>J Allergy Clin Immunol</addtitle><description>The epidermis protects human subjects from exogenous stressors and helps to maintain internal fluid and electrolyte homeostasis. Filaggrin is a crucial epidermal protein that is important for the formation of the corneocyte, as well as the generation of its intracellular metabolites, which contribute to stratum corneum hydration and pH. The levels of filaggrin and its degradation products are influenced not only by the filaggrin genotype but also by inflammation and exogenous stressors. Pertinently, filaggrin deficiency is observed in patients with atopic dermatitis regardless of filaggrin mutation status, suggesting that the absence of filaggrin is a key factor in the pathogenesis of this skin condition. In this article we review the various causes of low filaggrin levels, centralizing the functional and morphologic role of a deficiency in filaggrin, its metabolites, or both in the etiopathogenesis of atopic dermatitis.</description><subject>Allergic diseases</subject><subject>Allergy and Immunology</subject><subject>Amino acids</subject><subject>Animals</subject><subject>Atopic dermatitis</subject><subject>barrier function</subject><subject>Biological and medical sciences</subject><subject>Cell Membrane Permeability</subject><subject>Cell Surface Extensions - metabolism</subject><subject>Cell Surface Extensions - pathology</subject><subject>Cytokines</subject><subject>Cytokines - immunology</subject><subject>Dermatitis, Atopic - genetics</subject><subject>Dermatitis, Atopic - immunology</subject><subject>Dermatology</subject><subject>Down-Regulation</subject><subject>Dyskeratosis</subject><subject>Epidermis - immunology</subject><subject>filaggrin</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Fundamental immunology</subject><subject>Genetic Predisposition to Disease</subject><subject>histidine</subject><subject>Homeostasis</subject><subject>Human subjects</subject><subject>Humans</subject><subject>Hydration</subject><subject>ichthyosis vulgaris</subject><subject>Immunopathology</subject><subject>Intermediate Filament Proteins - deficiency</subject><subject>Intermediate Filament Proteins - genetics</subject><subject>lamellar body</subject><subject>Lipid Metabolism</subject><subject>Lipids</subject><subject>Medical sciences</subject><subject>Metabolites</subject><subject>Mice</subject><subject>Microorganisms</subject><subject>Mutation</subject><subject>Pathogenesis</subject><subject>Proteins</subject><subject>Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis</subject><subject>Skin</subject><subject>Skin allergic diseases. Stinging insect allergies</subject><subject>stratum corneum</subject><subject>Stress, Psychological - immunology</subject><subject>Th2 Cells - immunology</subject><subject>TH2 cytokines</subject><subject>urocanic acid</subject><issn>0091-6749</issn><issn>1097-6825</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkt-L1DAQx4so3nr6D_ggARF8aZ2kTZqCCLL4Cw58UMG3kE0me6ndpiatcP-96e7qwT2ID2EY8pnvZPKdonhKoaJAxau-6rXxFQPaVCCqHO4VGwpdWwrJ-P1iA9DRUrRNd1E8SqmHnNeye1hcMA6Ct7TbFGqrl4SJBEdw8hbjQQ_E-UHv99GPJKJdzOzDSPRoyXyNPpIYBiT5Lmdk0vN12OOIyR819Bwmb8hRZ_azT4-LB04PCZ-c42Xx7f27r9uP5dXnD5-2b69Kw2s-l9IaSkUta97UVgvHOHcOW9HuwFmwTjfSaLajbGc7DkZTbCWnziAaYZua15fFy5PuFMPPBdOsDj4ZHAY9YliSooKJfGTT_g_KBMiWi4w-v4P2YYljHiRTtKEgJWsyxU6UiSGliE5N0R90vFEU1OqU6tXqlFqdUiBUDrno2Vl62R3Q_i35Y00GXpwBnYweXNSj8emWk1K2cBzn9YnD_L2_PEaVjMfRoPURzaxs8P9-x5s75Wbwo88df-ANptt5VWIK1Jd1p9aVog2AFPX3-jdeR8YS</recordid><startdate>20141001</startdate><enddate>20141001</enddate><creator>Thyssen, Jacob P., MD, PhD</creator><creator>Kezic, Sanja, PhD</creator><general>Elsevier Inc</general><general>Elsevier</general><general>Elsevier Limited</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7SS</scope><scope>7T5</scope><scope>H94</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope></search><sort><creationdate>20141001</creationdate><title>Causes of epidermal filaggrin reduction and their role in the pathogenesis of atopic dermatitis</title><author>Thyssen, Jacob P., MD, PhD ; Kezic, Sanja, PhD</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c535t-8dc116383543da6f255ffe767b0fd0dfa48ca2b12bd950ca1e7851fceec6d4353</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Allergic diseases</topic><topic>Allergy and Immunology</topic><topic>Amino acids</topic><topic>Animals</topic><topic>Atopic dermatitis</topic><topic>barrier function</topic><topic>Biological and medical sciences</topic><topic>Cell Membrane Permeability</topic><topic>Cell Surface Extensions - metabolism</topic><topic>Cell Surface Extensions - pathology</topic><topic>Cytokines</topic><topic>Cytokines - immunology</topic><topic>Dermatitis, Atopic - genetics</topic><topic>Dermatitis, Atopic - immunology</topic><topic>Dermatology</topic><topic>Down-Regulation</topic><topic>Dyskeratosis</topic><topic>Epidermis - immunology</topic><topic>filaggrin</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Fundamental immunology</topic><topic>Genetic Predisposition to Disease</topic><topic>histidine</topic><topic>Homeostasis</topic><topic>Human subjects</topic><topic>Humans</topic><topic>Hydration</topic><topic>ichthyosis vulgaris</topic><topic>Immunopathology</topic><topic>Intermediate Filament Proteins - deficiency</topic><topic>Intermediate Filament Proteins - genetics</topic><topic>lamellar body</topic><topic>Lipid Metabolism</topic><topic>Lipids</topic><topic>Medical sciences</topic><topic>Metabolites</topic><topic>Mice</topic><topic>Microorganisms</topic><topic>Mutation</topic><topic>Pathogenesis</topic><topic>Proteins</topic><topic>Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis</topic><topic>Skin</topic><topic>Skin allergic diseases. Stinging insect allergies</topic><topic>stratum corneum</topic><topic>Stress, Psychological - immunology</topic><topic>Th2 Cells - immunology</topic><topic>TH2 cytokines</topic><topic>urocanic acid</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Thyssen, Jacob P., MD, PhD</creatorcontrib><creatorcontrib>Kezic, Sanja, PhD</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of allergy and clinical immunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Thyssen, Jacob P., MD, PhD</au><au>Kezic, Sanja, PhD</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Causes of epidermal filaggrin reduction and their role in the pathogenesis of atopic dermatitis</atitle><jtitle>Journal of allergy and clinical immunology</jtitle><addtitle>J Allergy Clin Immunol</addtitle><date>2014-10-01</date><risdate>2014</risdate><volume>134</volume><issue>4</issue><spage>792</spage><epage>799</epage><pages>792-799</pages><issn>0091-6749</issn><eissn>1097-6825</eissn><coden>JACIBY</coden><abstract>The epidermis protects human subjects from exogenous stressors and helps to maintain internal fluid and electrolyte homeostasis. Filaggrin is a crucial epidermal protein that is important for the formation of the corneocyte, as well as the generation of its intracellular metabolites, which contribute to stratum corneum hydration and pH. The levels of filaggrin and its degradation products are influenced not only by the filaggrin genotype but also by inflammation and exogenous stressors. Pertinently, filaggrin deficiency is observed in patients with atopic dermatitis regardless of filaggrin mutation status, suggesting that the absence of filaggrin is a key factor in the pathogenesis of this skin condition. In this article we review the various causes of low filaggrin levels, centralizing the functional and morphologic role of a deficiency in filaggrin, its metabolites, or both in the etiopathogenesis of atopic dermatitis.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>25065719</pmid><doi>10.1016/j.jaci.2014.06.014</doi><tpages>8</tpages></addata></record> |
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| subjects | Allergic diseases Allergy and Immunology Amino acids Animals Atopic dermatitis barrier function Biological and medical sciences Cell Membrane Permeability Cell Surface Extensions - metabolism Cell Surface Extensions - pathology Cytokines Cytokines - immunology Dermatitis, Atopic - genetics Dermatitis, Atopic - immunology Dermatology Down-Regulation Dyskeratosis Epidermis - immunology filaggrin Fundamental and applied biological sciences. Psychology Fundamental immunology Genetic Predisposition to Disease histidine Homeostasis Human subjects Humans Hydration ichthyosis vulgaris Immunopathology Intermediate Filament Proteins - deficiency Intermediate Filament Proteins - genetics lamellar body Lipid Metabolism Lipids Medical sciences Metabolites Mice Microorganisms Mutation Pathogenesis Proteins Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis Skin Skin allergic diseases. Stinging insect allergies stratum corneum Stress, Psychological - immunology Th2 Cells - immunology TH2 cytokines urocanic acid |
| title | Causes of epidermal filaggrin reduction and their role in the pathogenesis of atopic dermatitis |
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