Eye enucleation alters intracellular distribution of NO synthase in the superior colliculus
WE investigated the role of retinotectal projections on the distribution of nitric oxide synthase (NOS) in the retinoceptive layers of the rat superior colliculus (SC) using histochemical methods. Rats enucleated at birth showed no alteration in the temporal pattern of NOS expression. There was, how...
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| Veröffentlicht in: | Neuroreport 1998-01, Vol.9 (1), p.145-148 |
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| creator | Tenório, Frank Giraldi-Guimarães, Arthur Santos, Hélio R Cintra, Wagner M Mendez-Otero, Rosália |
| description | WE investigated the role of retinotectal projections on the distribution of nitric oxide synthase (NOS) in the retinoceptive layers of the rat superior colliculus (SC) using histochemical methods. Rats enucleated at birth showed no alteration in the temporal pattern of NOS expression. There was, however, a dramatic change in the NADPH-diaphorase staining pattern of NOS-positive cells. NOS was absent from the distal portions of the dendritic trees of the deafferented SC. Nevertheless, staining the dendritic trees of these cells with Lucifer yellow showed that they were not morphologically different from those of the ipsilateral SC of monoenucleated animals. The same results were obtained when enucleation was performed in adult rats. We conclude that NOS intracellular distribution in the SC cells can be regulated by retinotectal projections in both developing and adult animals. |
| doi_str_mv | 10.1097/00001756-199801050-00029 |
| format | Article |
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Rats enucleated at birth showed no alteration in the temporal pattern of NOS expression. There was, however, a dramatic change in the NADPH-diaphorase staining pattern of NOS-positive cells. NOS was absent from the distal portions of the dendritic trees of the deafferented SC. Nevertheless, staining the dendritic trees of these cells with Lucifer yellow showed that they were not morphologically different from those of the ipsilateral SC of monoenucleated animals. The same results were obtained when enucleation was performed in adult rats. We conclude that NOS intracellular distribution in the SC cells can be regulated by retinotectal projections in both developing and adult animals.</description><identifier>ISSN: 0959-4965</identifier><identifier>EISSN: 1473-558X</identifier><identifier>DOI: 10.1097/00001756-199801050-00029</identifier><identifier>PMID: 9592065</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott-Raven Publishers</publisher><subject>Analysis of Variance ; Animals ; Biological and medical sciences ; Eye and associated structures. Visual pathways and centers. Vision ; Eye Enucleation ; Fundamental and applied biological sciences. Psychology ; Histocytochemistry ; NADPH Dehydrogenase ; Nitric Oxide Synthase - analysis ; Rats ; Rats, Inbred Strains ; Retina - physiology ; Superior Colliculi - cytology ; Superior Colliculi - enzymology ; Vertebrates: nervous system and sense organs ; Visual Pathways - physiology</subject><ispartof>Neuroreport, 1998-01, Vol.9 (1), p.145-148</ispartof><rights>Lippincott-Raven Publishers.</rights><rights>1998 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3849-970075cf4ee817906d91fa56cd477b333f89d589b84e12f60d3b7f61fd15f99f3</citedby><cites>FETCH-LOGICAL-c3849-970075cf4ee817906d91fa56cd477b333f89d589b84e12f60d3b7f61fd15f99f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2106212$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9592065$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tenório, Frank</creatorcontrib><creatorcontrib>Giraldi-Guimarães, Arthur</creatorcontrib><creatorcontrib>Santos, Hélio R</creatorcontrib><creatorcontrib>Cintra, Wagner M</creatorcontrib><creatorcontrib>Mendez-Otero, Rosália</creatorcontrib><title>Eye enucleation alters intracellular distribution of NO synthase in the superior colliculus</title><title>Neuroreport</title><addtitle>Neuroreport</addtitle><description>WE investigated the role of retinotectal projections on the distribution of nitric oxide synthase (NOS) in the retinoceptive layers of the rat superior colliculus (SC) using histochemical methods. Rats enucleated at birth showed no alteration in the temporal pattern of NOS expression. There was, however, a dramatic change in the NADPH-diaphorase staining pattern of NOS-positive cells. NOS was absent from the distal portions of the dendritic trees of the deafferented SC. Nevertheless, staining the dendritic trees of these cells with Lucifer yellow showed that they were not morphologically different from those of the ipsilateral SC of monoenucleated animals. The same results were obtained when enucleation was performed in adult rats. We conclude that NOS intracellular distribution in the SC cells can be regulated by retinotectal projections in both developing and adult animals.</description><subject>Analysis of Variance</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Eye and associated structures. Visual pathways and centers. Vision</subject><subject>Eye Enucleation</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Histocytochemistry</subject><subject>NADPH Dehydrogenase</subject><subject>Nitric Oxide Synthase - analysis</subject><subject>Rats</subject><subject>Rats, Inbred Strains</subject><subject>Retina - physiology</subject><subject>Superior Colliculi - cytology</subject><subject>Superior Colliculi - enzymology</subject><subject>Vertebrates: nervous system and sense organs</subject><subject>Visual Pathways - physiology</subject><issn>0959-4965</issn><issn>1473-558X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kUtLJDEQgIOs6Pj4CUIOy95ak-7O6yjiqiB6URA8hHS6wkQz3WPSQebfb-bh3DaXQNVXqaovCGFKLilR4oqUQwXjFVVKEkoYqUqkVgdoRlvRVIzJt19oRhRTVas4O0YnKX0URBEqj9BRideEsxl6v10BhiHbAGby44BNmCAm7IcpGgsh5GAi7n2aou_yhhgdfnrGaTVMc5OgkHiaA055CdGPEdsxBG9zyOkMHToTEpzv7lP0-vf25ea-eny-e7i5fqxsI1tVKUGIYNa1AJIKRXivqDOM274VomuaxknVM6k62QKtHSd90wnHqespc0q55hT92b67jONXhjTphU_r2c0AY06a8nq9riyg3II2jilFcHoZ_cLElaZEr73qH69671VvvJbSi12P3C2g3xfuRJb8713eJGuCi2awPu2xmhJe07pg7Rb7HjeeP0P-hqjnULTP9f9-tfkHXEWQeA</recordid><startdate>19980105</startdate><enddate>19980105</enddate><creator>Tenório, Frank</creator><creator>Giraldi-Guimarães, Arthur</creator><creator>Santos, Hélio R</creator><creator>Cintra, Wagner M</creator><creator>Mendez-Otero, Rosália</creator><general>Lippincott-Raven Publishers</general><general>Lippincott Williams and Wilkins</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope></search><sort><creationdate>19980105</creationdate><title>Eye enucleation alters intracellular distribution of NO synthase in the superior colliculus</title><author>Tenório, Frank ; Giraldi-Guimarães, Arthur ; Santos, Hélio R ; Cintra, Wagner M ; Mendez-Otero, Rosália</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3849-970075cf4ee817906d91fa56cd477b333f89d589b84e12f60d3b7f61fd15f99f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>Analysis of Variance</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Eye and associated structures. Visual pathways and centers. Vision</topic><topic>Eye Enucleation</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Histocytochemistry</topic><topic>NADPH Dehydrogenase</topic><topic>Nitric Oxide Synthase - analysis</topic><topic>Rats</topic><topic>Rats, Inbred Strains</topic><topic>Retina - physiology</topic><topic>Superior Colliculi - cytology</topic><topic>Superior Colliculi - enzymology</topic><topic>Vertebrates: nervous system and sense organs</topic><topic>Visual Pathways - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tenório, Frank</creatorcontrib><creatorcontrib>Giraldi-Guimarães, Arthur</creatorcontrib><creatorcontrib>Santos, Hélio R</creatorcontrib><creatorcontrib>Cintra, Wagner M</creatorcontrib><creatorcontrib>Mendez-Otero, Rosália</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><jtitle>Neuroreport</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tenório, Frank</au><au>Giraldi-Guimarães, Arthur</au><au>Santos, Hélio R</au><au>Cintra, Wagner M</au><au>Mendez-Otero, Rosália</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Eye enucleation alters intracellular distribution of NO synthase in the superior colliculus</atitle><jtitle>Neuroreport</jtitle><addtitle>Neuroreport</addtitle><date>1998-01-05</date><risdate>1998</risdate><volume>9</volume><issue>1</issue><spage>145</spage><epage>148</epage><pages>145-148</pages><issn>0959-4965</issn><eissn>1473-558X</eissn><abstract>WE investigated the role of retinotectal projections on the distribution of nitric oxide synthase (NOS) in the retinoceptive layers of the rat superior colliculus (SC) using histochemical methods. Rats enucleated at birth showed no alteration in the temporal pattern of NOS expression. There was, however, a dramatic change in the NADPH-diaphorase staining pattern of NOS-positive cells. NOS was absent from the distal portions of the dendritic trees of the deafferented SC. Nevertheless, staining the dendritic trees of these cells with Lucifer yellow showed that they were not morphologically different from those of the ipsilateral SC of monoenucleated animals. The same results were obtained when enucleation was performed in adult rats. We conclude that NOS intracellular distribution in the SC cells can be regulated by retinotectal projections in both developing and adult animals.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott-Raven Publishers</pub><pmid>9592065</pmid><doi>10.1097/00001756-199801050-00029</doi><tpages>4</tpages></addata></record> |
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| subjects | Analysis of Variance Animals Biological and medical sciences Eye and associated structures. Visual pathways and centers. Vision Eye Enucleation Fundamental and applied biological sciences. Psychology Histocytochemistry NADPH Dehydrogenase Nitric Oxide Synthase - analysis Rats Rats, Inbred Strains Retina - physiology Superior Colliculi - cytology Superior Colliculi - enzymology Vertebrates: nervous system and sense organs Visual Pathways - physiology |
| title | Eye enucleation alters intracellular distribution of NO synthase in the superior colliculus |
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