Antecedent Antimicrobial Use Increases the Risk of Uncomplicated Cystitis in Young Women
To examine whether antecedent antimicrobial use influenced subsequent relative risk of urinary tract infection (UTI) in premenopausal women, data were analyzed from two cohorts of women observed prospectively for 6 months to determine risk factors for UTI. Using a Cox proportional hazards model to a...
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| Veröffentlicht in: | Clinical infectious diseases 1997-07, Vol.25 (1), p.63-68 |
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| container_title | Clinical infectious diseases |
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| creator | Smith, Heidi S. Hughes, James P. Hooton, Thomas M. Roberts, Pacita Scholes, Delia Stergachis, Andy Stapleton, Ann Stamm, Walter E. |
| description | To examine whether antecedent antimicrobial use influenced subsequent relative risk of urinary tract infection (UTI) in premenopausal women, data were analyzed from two cohorts of women observed prospectively for 6 months to determine risk factors for UTI. Using a Cox proportional hazards model to adjust for covariates, we found that 326 women in a University cohort and 425 women in a health-maintenance organization cohort were at increased risks for UTI (2.57 [95% confidence interval (CI), 1.24–5.32] and 5.83 [95% CI, 3.17–10.70], respectively) if antimicrobials had been taken during the previous 15–28 days but not during the previous 3, 7, or 14 days. The increased risks were noted both for women whose antimicrobial use was for treatment of a previous UTI and for women who received antimicrobials for other illnesses. These results suggest that recent antimicrobial use increases a woman's risk of UTI, perhaps by altering the indigenous urogenital flora and predisposing to vaginal colonization with uropathogens. |
| doi_str_mv | 10.1086/514502 |
| format | Article |
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Using a Cox proportional hazards model to adjust for covariates, we found that 326 women in a University cohort and 425 women in a health-maintenance organization cohort were at increased risks for UTI (2.57 [95% confidence interval (CI), 1.24–5.32] and 5.83 [95% CI, 3.17–10.70], respectively) if antimicrobials had been taken during the previous 15–28 days but not during the previous 3, 7, or 14 days. The increased risks were noted both for women whose antimicrobial use was for treatment of a previous UTI and for women who received antimicrobials for other illnesses. These results suggest that recent antimicrobial use increases a woman's risk of UTI, perhaps by altering the indigenous urogenital flora and predisposing to vaginal colonization with uropathogens.</description><identifier>ISSN: 1058-4838</identifier><identifier>EISSN: 1537-6591</identifier><identifier>DOI: 10.1086/514502</identifier><identifier>PMID: 9243034</identifier><identifier>CODEN: CIDIEL</identifier><language>eng</language><publisher>Chicago, IL: The University of Chicago Press</publisher><subject>Adolescent ; Adult ; Anti-Infective Agents - adverse effects ; Antimicrobials ; Bacterial diseases ; Bacterial diseases of the urinary system ; Biological and medical sciences ; Clinical Articles ; Cohort Studies ; Cystitis ; Cystitis - epidemiology ; Cystitis - etiology ; Diaries ; Female ; Flora ; Follow-Up Studies ; Health maintenance organizations ; Human bacterial diseases ; Humans ; Infections ; Infectious diseases ; Longitudinal Studies ; Medical sciences ; Predisposing factors ; Prospective Studies ; Recurrence ; Risk Factors ; Spermicides ; Urinary tract infections ; Womens health</subject><ispartof>Clinical infectious diseases, 1997-07, Vol.25 (1), p.63-68</ispartof><rights>Copyright 1997 The University of Chicago</rights><rights>1997 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c450t-5ddac942e20c4bc920f7d495a95064ce8cad550a36223858a9ce28ae9d6e44c33</citedby><cites>FETCH-LOGICAL-c450t-5ddac942e20c4bc920f7d495a95064ce8cad550a36223858a9ce28ae9d6e44c33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/4460081$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/4460081$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,776,780,799,27901,27902,57992,58225</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2741056$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9243034$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Smith, Heidi S.</creatorcontrib><creatorcontrib>Hughes, James P.</creatorcontrib><creatorcontrib>Hooton, Thomas M.</creatorcontrib><creatorcontrib>Roberts, Pacita</creatorcontrib><creatorcontrib>Scholes, Delia</creatorcontrib><creatorcontrib>Stergachis, Andy</creatorcontrib><creatorcontrib>Stapleton, Ann</creatorcontrib><creatorcontrib>Stamm, Walter E.</creatorcontrib><title>Antecedent Antimicrobial Use Increases the Risk of Uncomplicated Cystitis in Young Women</title><title>Clinical infectious diseases</title><addtitle>Clinical Infectious Diseases</addtitle><description>To examine whether antecedent antimicrobial use influenced subsequent relative risk of urinary tract infection (UTI) in premenopausal women, data were analyzed from two cohorts of women observed prospectively for 6 months to determine risk factors for UTI. Using a Cox proportional hazards model to adjust for covariates, we found that 326 women in a University cohort and 425 women in a health-maintenance organization cohort were at increased risks for UTI (2.57 [95% confidence interval (CI), 1.24–5.32] and 5.83 [95% CI, 3.17–10.70], respectively) if antimicrobials had been taken during the previous 15–28 days but not during the previous 3, 7, or 14 days. The increased risks were noted both for women whose antimicrobial use was for treatment of a previous UTI and for women who received antimicrobials for other illnesses. These results suggest that recent antimicrobial use increases a woman's risk of UTI, perhaps by altering the indigenous urogenital flora and predisposing to vaginal colonization with uropathogens.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Anti-Infective Agents - adverse effects</subject><subject>Antimicrobials</subject><subject>Bacterial diseases</subject><subject>Bacterial diseases of the urinary system</subject><subject>Biological and medical sciences</subject><subject>Clinical Articles</subject><subject>Cohort Studies</subject><subject>Cystitis</subject><subject>Cystitis - epidemiology</subject><subject>Cystitis - etiology</subject><subject>Diaries</subject><subject>Female</subject><subject>Flora</subject><subject>Follow-Up Studies</subject><subject>Health maintenance organizations</subject><subject>Human bacterial diseases</subject><subject>Humans</subject><subject>Infections</subject><subject>Infectious diseases</subject><subject>Longitudinal Studies</subject><subject>Medical sciences</subject><subject>Predisposing factors</subject><subject>Prospective Studies</subject><subject>Recurrence</subject><subject>Risk Factors</subject><subject>Spermicides</subject><subject>Urinary tract infections</subject><subject>Womens health</subject><issn>1058-4838</issn><issn>1537-6591</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkF1LHDEUhkOpqNX6CyzkQno3Nd-TubSLVWGhRVxqvQnZzBmNzmS2OVnQf9-RXbZX58DzcD5eQk44-8aZNeeaK83EB3LItawroxv-ceqZtpWy0h6QT4jPjHFumd4n-41Qkkl1SO4vUoEALaRCpzYOMeRxGX1PFwj0JoUMHgFpeQJ6G_GFjh1dpDAOqz4GX6ClszcssUSkMdE_4zo90t_jAOmY7HW-R_i8rUdk8ePybnZdzX9e3cwu5lWY7i2VblsfGiVAsKCWoRGsq1vVaN9oZlQAG3yrNfPSCCGttr4JIKyHpjWgVJDyiHzdzF3l8e8asLghYoC-9wnGNTpuhLZGmP_i9CBihs6tchx8fnOcufcI3SbCSfyynbheDtDutG1mEz_bco_B9132KUTcaaJWU-zv-0432jOWMe-wUoYxyydcbXDEAq877POLM7Wstbu-f3B3v-bf61sh3ZX8ByiOj7w</recordid><startdate>19970701</startdate><enddate>19970701</enddate><creator>Smith, Heidi S.</creator><creator>Hughes, James P.</creator><creator>Hooton, Thomas M.</creator><creator>Roberts, Pacita</creator><creator>Scholes, Delia</creator><creator>Stergachis, Andy</creator><creator>Stapleton, Ann</creator><creator>Stamm, Walter E.</creator><general>The University of Chicago Press</general><general>University of Chicago Press</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7U1</scope><scope>7U2</scope><scope>C1K</scope></search><sort><creationdate>19970701</creationdate><title>Antecedent Antimicrobial Use Increases the Risk of Uncomplicated Cystitis in Young Women</title><author>Smith, Heidi S. ; Hughes, James P. ; Hooton, Thomas M. ; Roberts, Pacita ; Scholes, Delia ; Stergachis, Andy ; Stapleton, Ann ; Stamm, Walter E.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c450t-5ddac942e20c4bc920f7d495a95064ce8cad550a36223858a9ce28ae9d6e44c33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1997</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Anti-Infective Agents - adverse effects</topic><topic>Antimicrobials</topic><topic>Bacterial diseases</topic><topic>Bacterial diseases of the urinary system</topic><topic>Biological and medical sciences</topic><topic>Clinical Articles</topic><topic>Cohort Studies</topic><topic>Cystitis</topic><topic>Cystitis - epidemiology</topic><topic>Cystitis - etiology</topic><topic>Diaries</topic><topic>Female</topic><topic>Flora</topic><topic>Follow-Up Studies</topic><topic>Health maintenance organizations</topic><topic>Human bacterial diseases</topic><topic>Humans</topic><topic>Infections</topic><topic>Infectious diseases</topic><topic>Longitudinal Studies</topic><topic>Medical sciences</topic><topic>Predisposing factors</topic><topic>Prospective Studies</topic><topic>Recurrence</topic><topic>Risk Factors</topic><topic>Spermicides</topic><topic>Urinary tract infections</topic><topic>Womens health</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Smith, Heidi S.</creatorcontrib><creatorcontrib>Hughes, James P.</creatorcontrib><creatorcontrib>Hooton, Thomas M.</creatorcontrib><creatorcontrib>Roberts, Pacita</creatorcontrib><creatorcontrib>Scholes, Delia</creatorcontrib><creatorcontrib>Stergachis, Andy</creatorcontrib><creatorcontrib>Stapleton, Ann</creatorcontrib><creatorcontrib>Stamm, Walter E.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Risk Abstracts</collection><collection>Safety Science and Risk</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>Clinical infectious diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Smith, Heidi S.</au><au>Hughes, James P.</au><au>Hooton, Thomas M.</au><au>Roberts, Pacita</au><au>Scholes, Delia</au><au>Stergachis, Andy</au><au>Stapleton, Ann</au><au>Stamm, Walter E.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Antecedent Antimicrobial Use Increases the Risk of Uncomplicated Cystitis in Young Women</atitle><jtitle>Clinical infectious diseases</jtitle><addtitle>Clinical Infectious Diseases</addtitle><date>1997-07-01</date><risdate>1997</risdate><volume>25</volume><issue>1</issue><spage>63</spage><epage>68</epage><pages>63-68</pages><issn>1058-4838</issn><eissn>1537-6591</eissn><coden>CIDIEL</coden><abstract>To examine whether antecedent antimicrobial use influenced subsequent relative risk of urinary tract infection (UTI) in premenopausal women, data were analyzed from two cohorts of women observed prospectively for 6 months to determine risk factors for UTI. Using a Cox proportional hazards model to adjust for covariates, we found that 326 women in a University cohort and 425 women in a health-maintenance organization cohort were at increased risks for UTI (2.57 [95% confidence interval (CI), 1.24–5.32] and 5.83 [95% CI, 3.17–10.70], respectively) if antimicrobials had been taken during the previous 15–28 days but not during the previous 3, 7, or 14 days. The increased risks were noted both for women whose antimicrobial use was for treatment of a previous UTI and for women who received antimicrobials for other illnesses. These results suggest that recent antimicrobial use increases a woman's risk of UTI, perhaps by altering the indigenous urogenital flora and predisposing to vaginal colonization with uropathogens.</abstract><cop>Chicago, IL</cop><pub>The University of Chicago Press</pub><pmid>9243034</pmid><doi>10.1086/514502</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Clinical infectious diseases, 1997-07, Vol.25 (1), p.63-68 |
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| source | Jstor Complete Legacy; Oxford University Press Journals All Titles (1996-Current); MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Adolescent Adult Anti-Infective Agents - adverse effects Antimicrobials Bacterial diseases Bacterial diseases of the urinary system Biological and medical sciences Clinical Articles Cohort Studies Cystitis Cystitis - epidemiology Cystitis - etiology Diaries Female Flora Follow-Up Studies Health maintenance organizations Human bacterial diseases Humans Infections Infectious diseases Longitudinal Studies Medical sciences Predisposing factors Prospective Studies Recurrence Risk Factors Spermicides Urinary tract infections Womens health |
| title | Antecedent Antimicrobial Use Increases the Risk of Uncomplicated Cystitis in Young Women |
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