The differential effects of hepatotoxicants on the sulfation pathway in rats

This study characterized the effects of liver damage produced by a variety of hepatotoxicants on several components of the sulfation pathway in rats. Specifically, the concentration of cosubstrate, adenosine 3′-phosphate 5′-phosphosulfate (PAPS), and the hepatic capacity for PAPS synthesis were meas...

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Veröffentlicht in:	Toxicology and applied pharmacology 1991-09, Vol.110 (3), p.365-373
Hauptverfasser:	Maziasz, T.J., Liu, J., Madhu, C., Klaassen, C.D.
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Naphthylisothiocyanate - adverse effects 1-Propanol - adverse effects Aflatoxin B1 - adverse effects Alanine Transaminase - blood Animals Arylsulfotransferase - drug effects Arylsulfotransferase - metabolism Biological and medical sciences Bromobenzenes - adverse effects Cadmium - adverse effects Cadmium Chloride Carbon Tetrachloride - adverse effects Chemical and Drug Induced Liver Injury Cytosol - enzymology Dichloroethylenes - adverse effects General aspects. Methods L-Iditol 2-Dehydrogenase - blood Liver - drug effects Liver - enzymology Liver - metabolism Liver Diseases - enzymology Liver Diseases - metabolism Male Medical sciences Phosphoadenosine Phosphosulfate - biosynthesis Propanols Rats Rats, Inbred Strains Sulfates - metabolism Thioacetamide - adverse effects Toxicology
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