Efficacy of Two Commercial Products for Altering Urine Drug Test Results
Abstract Objective: We have become aware of several commercial products that, when orally ingested, will purportedly not only eliminate "toxins" from a person's system, but will also correct any Urinary imbalances caused by excessive water consumption. Method: Unblinded study of one v...
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| Veröffentlicht in: | Clinical toxicology (Philadelphia, Pa.) Pa.), 1997, Vol.35 (6), p.637-642 |
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| container_title | Clinical toxicology (Philadelphia, Pa.) |
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| creator | Coleman, Daniel E. Baselt, Randall C. |
| description | Abstract
Objective: We have become aware of several commercial products that, when orally ingested, will purportedly not only eliminate "toxins" from a person's system, but will also correct any Urinary imbalances caused by excessive water consumption. Method: Unblinded study of one volunteer subject, tested weekly × 4 for 24 hour urine elimination of test drug under conditions of control, control plus 1200 mL water, Quick Flush®, and Eliminator®. Results: Each of the treatment protocols studied caused reductions of drug or metabolite concentrations as measured by gas chromatography-mass spectrometry in urine specimens collected up to 24 hours after ingestion of amphetamine, 9-carboxy-l1-nor-delta-9-THC, benzoylecgonine, or codeine, yet the radioimmunoassay screening results demonstrated very little effect. Water alone was approximately as effective as the two commercial products in reducing the metabolite level. None of the treatment protocols employed in this study altered urinary pH, specific gravity, or creatinine concentration outside the normally accepted physiological range. Conclusions: Attempts to conceal drug abuse by water dilution are most likely to play a substantial role when concentrations are at or near the detection threshold for a particular assay such as the terminal stages of drug elimination |
| doi_str_mv | 10.3109/15563659709001246 |
| format | Article |
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Objective: We have become aware of several commercial products that, when orally ingested, will purportedly not only eliminate "toxins" from a person's system, but will also correct any Urinary imbalances caused by excessive water consumption. Method: Unblinded study of one volunteer subject, tested weekly × 4 for 24 hour urine elimination of test drug under conditions of control, control plus 1200 mL water, Quick Flush®, and Eliminator®. Results: Each of the treatment protocols studied caused reductions of drug or metabolite concentrations as measured by gas chromatography-mass spectrometry in urine specimens collected up to 24 hours after ingestion of amphetamine, 9-carboxy-l1-nor-delta-9-THC, benzoylecgonine, or codeine, yet the radioimmunoassay screening results demonstrated very little effect. Water alone was approximately as effective as the two commercial products in reducing the metabolite level. None of the treatment protocols employed in this study altered urinary pH, specific gravity, or creatinine concentration outside the normally accepted physiological range. Conclusions: Attempts to conceal drug abuse by water dilution are most likely to play a substantial role when concentrations are at or near the detection threshold for a particular assay such as the terminal stages of drug elimination</description><identifier>ISSN: 1556-3650</identifier><identifier>ISSN: 0731-3810</identifier><identifier>EISSN: 1556-9519</identifier><identifier>EISSN: 1097-9875</identifier><identifier>DOI: 10.3109/15563659709001246</identifier><identifier>PMID: 9365433</identifier><language>eng</language><publisher>Monticello, NY: Informa UK Ltd</publisher><subject>Amphetamine - urine ; Biological and medical sciences ; Cocaine - analogs & derivatives ; Cocaine - urine ; Codeine - urine ; Creatinine - urine ; Dronabinol - urine ; Drug addictions ; Drug and Narcotic Control - methods ; Gas Chromatography-Mass Spectrometry ; Humans ; Male ; Medical sciences ; Radioimmunoassay ; Street Drugs - urine ; Substance Abuse Detection - methods ; Substance-Related Disorders - urine ; Toxicology ; Urinalysis - methods</subject><ispartof>Clinical toxicology (Philadelphia, Pa.), 1997, Vol.35 (6), p.637-642</ispartof><rights>1997 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted 1997</rights><rights>1998 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c461t-58d68f67c12b015eff9e61080d5836ca82c8f683795bbae88dce273eb230f0c73</citedby><cites>FETCH-LOGICAL-c461t-58d68f67c12b015eff9e61080d5836ca82c8f683795bbae88dce273eb230f0c73</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.tandfonline.com/doi/pdf/10.3109/15563659709001246$$EPDF$$P50$$Ginformaworld$$H</linktopdf><linktohtml>$$Uhttps://www.tandfonline.com/doi/full/10.3109/15563659709001246$$EHTML$$P50$$Ginformaworld$$H</linktohtml><link.rule.ids>314,780,784,4024,27923,27924,27925,59647,59753,60436,60542,61221,61256,61402,61437</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2045650$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9365433$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Coleman, Daniel E.</creatorcontrib><creatorcontrib>Baselt, Randall C.</creatorcontrib><title>Efficacy of Two Commercial Products for Altering Urine Drug Test Results</title><title>Clinical toxicology (Philadelphia, Pa.)</title><addtitle>J Toxicol Clin Toxicol</addtitle><description>Abstract
Objective: We have become aware of several commercial products that, when orally ingested, will purportedly not only eliminate "toxins" from a person's system, but will also correct any Urinary imbalances caused by excessive water consumption. Method: Unblinded study of one volunteer subject, tested weekly × 4 for 24 hour urine elimination of test drug under conditions of control, control plus 1200 mL water, Quick Flush®, and Eliminator®. Results: Each of the treatment protocols studied caused reductions of drug or metabolite concentrations as measured by gas chromatography-mass spectrometry in urine specimens collected up to 24 hours after ingestion of amphetamine, 9-carboxy-l1-nor-delta-9-THC, benzoylecgonine, or codeine, yet the radioimmunoassay screening results demonstrated very little effect. Water alone was approximately as effective as the two commercial products in reducing the metabolite level. None of the treatment protocols employed in this study altered urinary pH, specific gravity, or creatinine concentration outside the normally accepted physiological range. Conclusions: Attempts to conceal drug abuse by water dilution are most likely to play a substantial role when concentrations are at or near the detection threshold for a particular assay such as the terminal stages of drug elimination</description><subject>Amphetamine - urine</subject><subject>Biological and medical sciences</subject><subject>Cocaine - analogs & derivatives</subject><subject>Cocaine - urine</subject><subject>Codeine - urine</subject><subject>Creatinine - urine</subject><subject>Dronabinol - urine</subject><subject>Drug addictions</subject><subject>Drug and Narcotic Control - methods</subject><subject>Gas Chromatography-Mass Spectrometry</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Radioimmunoassay</subject><subject>Street Drugs - urine</subject><subject>Substance Abuse Detection - methods</subject><subject>Substance-Related Disorders - urine</subject><subject>Toxicology</subject><subject>Urinalysis - methods</subject><issn>1556-3650</issn><issn>0731-3810</issn><issn>1556-9519</issn><issn>1097-9875</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1LxDAQhoMofv8AD0IO4m01aZo0QS_L-gkLiuyeS5pOtJI2mrTI_nsjWwURvCRh5nmHyYPQESVnjBJ1TjkXTHBVEEUIzXKxgXa_ahPFqdoc3wkgO2gvxldCmMwV3UbbKhVzxnbR3bW1jdFmhb3Fiw-PZ75tIZhGO_wYfD2YPmLrA566HkLTPeNlOgFfheEZLyD2-Ani4Pp4gLasdhEOx3sfLW-uF7O7yfzh9n42nU9MLmg_4bIW0orC0KwilIO1CgQlktRcMmG0zExqS1YoXlUapKwNZAWDKmPEElOwfXS6nvsW_PuQFijbJhpwTnfgh1hSkfG8kDKBdA2a4GMMYMu30LQ6rEpKyi975R97KXM8Dh-qFuqfxKgr9U_Gvo5GOxt0Z5r4g2Uk50l2wi7XWNMlda3-8MHVZa9XzofvDPtvi4tf8RfQrn8xOkD56ofQJb3__OET04ebKQ</recordid><startdate>1997</startdate><enddate>1997</enddate><creator>Coleman, Daniel E.</creator><creator>Baselt, Randall C.</creator><general>Informa UK Ltd</general><general>Taylor & Francis</general><general>Dekker</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U7</scope><scope>C1K</scope></search><sort><creationdate>1997</creationdate><title>Efficacy of Two Commercial Products for Altering Urine Drug Test Results</title><author>Coleman, Daniel E. ; Baselt, Randall C.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c461t-58d68f67c12b015eff9e61080d5836ca82c8f683795bbae88dce273eb230f0c73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1997</creationdate><topic>Amphetamine - urine</topic><topic>Biological and medical sciences</topic><topic>Cocaine - analogs & derivatives</topic><topic>Cocaine - urine</topic><topic>Codeine - urine</topic><topic>Creatinine - urine</topic><topic>Dronabinol - urine</topic><topic>Drug addictions</topic><topic>Drug and Narcotic Control - methods</topic><topic>Gas Chromatography-Mass Spectrometry</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Radioimmunoassay</topic><topic>Street Drugs - urine</topic><topic>Substance Abuse Detection - methods</topic><topic>Substance-Related Disorders - urine</topic><topic>Toxicology</topic><topic>Urinalysis - methods</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Coleman, Daniel E.</creatorcontrib><creatorcontrib>Baselt, Randall C.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>Clinical toxicology (Philadelphia, Pa.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Coleman, Daniel E.</au><au>Baselt, Randall C.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Efficacy of Two Commercial Products for Altering Urine Drug Test Results</atitle><jtitle>Clinical toxicology (Philadelphia, Pa.)</jtitle><addtitle>J Toxicol Clin Toxicol</addtitle><date>1997</date><risdate>1997</risdate><volume>35</volume><issue>6</issue><spage>637</spage><epage>642</epage><pages>637-642</pages><issn>1556-3650</issn><issn>0731-3810</issn><eissn>1556-9519</eissn><eissn>1097-9875</eissn><abstract>Abstract
Objective: We have become aware of several commercial products that, when orally ingested, will purportedly not only eliminate "toxins" from a person's system, but will also correct any Urinary imbalances caused by excessive water consumption. Method: Unblinded study of one volunteer subject, tested weekly × 4 for 24 hour urine elimination of test drug under conditions of control, control plus 1200 mL water, Quick Flush®, and Eliminator®. Results: Each of the treatment protocols studied caused reductions of drug or metabolite concentrations as measured by gas chromatography-mass spectrometry in urine specimens collected up to 24 hours after ingestion of amphetamine, 9-carboxy-l1-nor-delta-9-THC, benzoylecgonine, or codeine, yet the radioimmunoassay screening results demonstrated very little effect. Water alone was approximately as effective as the two commercial products in reducing the metabolite level. None of the treatment protocols employed in this study altered urinary pH, specific gravity, or creatinine concentration outside the normally accepted physiological range. Conclusions: Attempts to conceal drug abuse by water dilution are most likely to play a substantial role when concentrations are at or near the detection threshold for a particular assay such as the terminal stages of drug elimination</abstract><cop>Monticello, NY</cop><pub>Informa UK Ltd</pub><pmid>9365433</pmid><doi>10.3109/15563659709001246</doi><tpages>6</tpages></addata></record> |
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| source | MEDLINE; Taylor & Francis:Master (3349 titles); Taylor & Francis Medical Library - CRKN |
| subjects | Amphetamine - urine Biological and medical sciences Cocaine - analogs & derivatives Cocaine - urine Codeine - urine Creatinine - urine Dronabinol - urine Drug addictions Drug and Narcotic Control - methods Gas Chromatography-Mass Spectrometry Humans Male Medical sciences Radioimmunoassay Street Drugs - urine Substance Abuse Detection - methods Substance-Related Disorders - urine Toxicology Urinalysis - methods |
| title | Efficacy of Two Commercial Products for Altering Urine Drug Test Results |
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