Dendritic Cell Maturation and Antigen Presentation in the Absence of Invariant Chain
In immature dendritic cells (DCs), major histocompatibility complex class II molecules accumulate in peptide-loading compartments and, during DC maturation, are exported to the cell surface in response to inflammatory stimuli. Moreover, it has recently been proposed that DCs have specific mechanisms...
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| Veröffentlicht in: | Proceedings of the National Academy of Sciences - PNAS 1998-02, Vol.95 (3), p.1067-1072 |
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| container_title | Proceedings of the National Academy of Sciences - PNAS |
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| creator | Rovere, Patrizia Zimmermann, Valerie S. Forquet, Frederique Demandolx, Denis Trucy, Jeannine Ricciardi-Castagnoli, Paola Davoust, Jean |
| description | In immature dendritic cells (DCs), major histocompatibility complex class II molecules accumulate in peptide-loading compartments and, during DC maturation, are exported to the cell surface in response to inflammatory stimuli. Moreover, it has recently been proposed that DCs have specific mechanisms of antigen uptake and delivery into major histocompatibility complex class II-loading compartments. B cells bearing a genetically disrupted invariant chain gene (Ii -/-) show alterations in the transport and function of class II molecules. We herein report that DCs derived from Ii -/- H2kbut not Ii -/- H2bmice undergo normal maturation in response to tumor necrosis factor α and show a high degree of class II surface expression. Class II molecules are accumulated in cathepsin D- and H2-M-positive compartments in immature Ii -/- DC and, during DC maturation, are exported to the cell membrane as compact dimers. Ii -/- DCs present putative Ii-dependent hen egg lysozyme-derived epitopes to T cells. These data support the existence of Ii-independent molecular requirements for class II transport and peptide loading in DCs. |
| doi_str_mv | 10.1073/pnas.95.3.1067 |
| format | Article |
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Moreover, it has recently been proposed that DCs have specific mechanisms of antigen uptake and delivery into major histocompatibility complex class II-loading compartments. B cells bearing a genetically disrupted invariant chain gene (Ii -/-) show alterations in the transport and function of class II molecules. We herein report that DCs derived from Ii -/- H2kbut not Ii -/- H2bmice undergo normal maturation in response to tumor necrosis factor α and show a high degree of class II surface expression. Class II molecules are accumulated in cathepsin D- and H2-M-positive compartments in immature Ii -/- DC and, during DC maturation, are exported to the cell membrane as compact dimers. Ii -/- DCs present putative Ii-dependent hen egg lysozyme-derived epitopes to T cells. 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Moreover, it has recently been proposed that DCs have specific mechanisms of antigen uptake and delivery into major histocompatibility complex class II-loading compartments. B cells bearing a genetically disrupted invariant chain gene (Ii -/-) show alterations in the transport and function of class II molecules. We herein report that DCs derived from Ii -/- H2kbut not Ii -/- H2bmice undergo normal maturation in response to tumor necrosis factor α and show a high degree of class II surface expression. Class II molecules are accumulated in cathepsin D- and H2-M-positive compartments in immature Ii -/- DC and, during DC maturation, are exported to the cell membrane as compact dimers. Ii -/- DCs present putative Ii-dependent hen egg lysozyme-derived epitopes to T cells. These data support the existence of Ii-independent molecular requirements for class II transport and peptide loading in DCs.</description><subject>Animals</subject><subject>Antigen Presentation</subject><subject>Antigens</subject><subject>Antigens, Differentiation, B-Lymphocyte - physiology</subject><subject>B lymphocytes</subject><subject>Biological Sciences</subject><subject>Cell membranes</subject><subject>Cells</subject><subject>Cellular biology</subject><subject>Dendritic Cells - cytology</subject><subject>Dendritic Cells - immunology</subject><subject>Dimers</subject><subject>Epitopes</subject><subject>Flow Cytometry</subject><subject>H-2 Antigens - immunology</subject><subject>Haplotypes</subject><subject>Histocompatibility Antigens Class II - physiology</subject><subject>Mice</subject><subject>Mice, Inbred C57BL</subject><subject>Microscopy, Confocal</subject><subject>Molecules</subject><subject>Neurons</subject><subject>Spleen</subject><subject>Spleen - cytology</subject><subject>T lymphocytes</subject><issn>0027-8424</issn><issn>1091-6490</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUFvEzEQhS1EVULhygEJyeLQ26b22t71SFyiUKBSKziUs-XdtRtHGzvY3gr-fR0ligIHKh8sz_veaDwPoXeUzClp2dXW6zQHMWfl2bQv0IwSoFXDgbxEM0LqtpK85q_Q65TWhBAQkpyjc-Bc1rKZofvPxg_RZdfjpRlHfKfzFHV2wWPtB7zw2T0Yj39Ek4zPe8F5nFcGL7pS6g0OFt_4Rx2d9hkvV9r5N-jM6jGZt4f7Av38cn2__Fbdfv96s1zcVr2gLFed5ETTgRjelnF6bfoOwErQkpnGasZLlVEQ1Fo2WKiFZOVIBgyo6GjLLtCnfd_t1G3M0JcJox7VNrqNjn9U0E79rXi3Ug_hUVHZtLzYLw_2GH5NJmW1cakvW9DehCmpFpq2BgrPgrSpBYOGFPDjP-A6TNGXHaiaUCaIkLRA8z3Ux5BSNPY4MCVql6naZapAKKZ2mRbDh9NvHvFDiCf6zndUT_yX_9OVncYxm9-5gO_34DrlEI8k5zXj7AlBOL0y</recordid><startdate>19980203</startdate><enddate>19980203</enddate><creator>Rovere, Patrizia</creator><creator>Zimmermann, Valerie S.</creator><creator>Forquet, Frederique</creator><creator>Demandolx, Denis</creator><creator>Trucy, Jeannine</creator><creator>Ricciardi-Castagnoli, Paola</creator><creator>Davoust, Jean</creator><general>National Academy of Sciences of the United States of America</general><general>National Acad Sciences</general><general>National Academy of Sciences</general><general>The National Academy of Sciences</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QG</scope><scope>7QL</scope><scope>7QP</scope><scope>7QR</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TK</scope><scope>7TM</scope><scope>7TO</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>M7N</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>19980203</creationdate><title>Dendritic Cell Maturation and Antigen Presentation in the Absence of Invariant Chain</title><author>Rovere, Patrizia ; 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| ispartof | Proceedings of the National Academy of Sciences - PNAS, 1998-02, Vol.95 (3), p.1067-1072 |
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| subjects | Animals Antigen Presentation Antigens Antigens, Differentiation, B-Lymphocyte - physiology B lymphocytes Biological Sciences Cell membranes Cells Cellular biology Dendritic Cells - cytology Dendritic Cells - immunology Dimers Epitopes Flow Cytometry H-2 Antigens - immunology Haplotypes Histocompatibility Antigens Class II - physiology Mice Mice, Inbred C57BL Microscopy, Confocal Molecules Neurons Spleen Spleen - cytology T lymphocytes |
| title | Dendritic Cell Maturation and Antigen Presentation in the Absence of Invariant Chain |
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