In vitro evidence of a tissue factor-independent mode of action of recombinant factor VIIa in hemophilia

Successful competition of activated factor VII (FVIIa) with zymogen factor VII (FVII) for tissue factor (TF) and loading of the platelet surface with FVIIa are plausible driving forces behind the pharmacological effect of recombinant FVIIa (rFVIIa) in hemophilia patients. Thrombin generation measure...

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Veröffentlicht in:	Blood 2014-11, Vol.124 (20), p.3172-3174
Hauptverfasser:	Augustsson, Cecilia, Persson, Egon
Format:	Artikel
Sprache:	eng
Schlagworte:	Coagulants - therapeutic use Factor VII - metabolism Factor VIIa - therapeutic use Factor VIII - metabolism Hemophilia A - blood Hemophilia A - drug therapy Humans Recombinant Proteins - therapeutic use Thrombin - analysis Thrombin - metabolism Thromboplastin - metabolism
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