Expressions of aquaporin-4, matrix metallo-proteinase-2 and matrix metallo-proteinase-14 in peritumor edematous zone of glioma and clinical implications
To distinguish the expressions of matrix metallo-poteinase and aquaporin in peritumor edematous zone and normal brain tissue for different pathological levels of glioma and explore the relationship of glioma cell invasiveness and brain edema. The immunohistochemical method of SP was employed to dete...
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| Veröffentlicht in: | Zhong hua yi xue za zhi 2014-08, Vol.94 (29), p.2290-2292 |
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| container_title | Zhong hua yi xue za zhi |
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| creator | Wang, Yang Guan, Shusen Zhao, Gang Shi, Pengqiang Wang, Jinzhong |
| description | To distinguish the expressions of matrix metallo-poteinase and aquaporin in peritumor edematous zone and normal brain tissue for different pathological levels of glioma and explore the relationship of glioma cell invasiveness and brain edema.
The immunohistochemical method of SP was employed to detect the expressions of aquaporin-4 (AQP-4), matrix metallo-proteinase-2 (MMP-2) and matrix metallo-proteinase-14 (MMP-14) in glioma and normal brain tissue. Due to a rarity of glioma Grades I and II, grades I and II glioma were pooled into low malignancy group (LMG) and grades III and IV into high malignancy group (HMG). The software program SPSS 11.0 was used for Kolmogorov-Smirnov test of independent samplets. The differences were detected between normal brain tissue and LMG and HMG. Also the relationship of AQP4, MMP-2 and MMP-14 was analyzed.
With the advancing pathological grades of glioma, the expression of AQP-4, MMP-2 and MMP-14 were higher in positive areas. There were significant deviations among 3 groups. |
| format | Article |
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The immunohistochemical method of SP was employed to detect the expressions of aquaporin-4 (AQP-4), matrix metallo-proteinase-2 (MMP-2) and matrix metallo-proteinase-14 (MMP-14) in glioma and normal brain tissue. Due to a rarity of glioma Grades I and II, grades I and II glioma were pooled into low malignancy group (LMG) and grades III and IV into high malignancy group (HMG). The software program SPSS 11.0 was used for Kolmogorov-Smirnov test of independent samplets. The differences were detected between normal brain tissue and LMG and HMG. Also the relationship of AQP4, MMP-2 and MMP-14 was analyzed.
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The immunohistochemical method of SP was employed to detect the expressions of aquaporin-4 (AQP-4), matrix metallo-proteinase-2 (MMP-2) and matrix metallo-proteinase-14 (MMP-14) in glioma and normal brain tissue. Due to a rarity of glioma Grades I and II, grades I and II glioma were pooled into low malignancy group (LMG) and grades III and IV into high malignancy group (HMG). The software program SPSS 11.0 was used for Kolmogorov-Smirnov test of independent samplets. The differences were detected between normal brain tissue and LMG and HMG. Also the relationship of AQP4, MMP-2 and MMP-14 was analyzed.
With the advancing pathological grades of glioma, the expression of AQP-4, MMP-2 and MMP-14 were higher in positive areas. There were significant deviations among 3 groups.</description><subject>Aquaporin 4 - metabolism</subject><subject>Brain Edema - metabolism</subject><subject>Brain Neoplasms - metabolism</subject><subject>Glioma - metabolism</subject><subject>Humans</subject><subject>Matrix Metalloproteinase 14 - metabolism</subject><subject>Matrix Metalloproteinase 2 - metabolism</subject><subject>Matrix Metalloproteinase 9</subject><issn>0376-2491</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kMtKAzEUhmeh2FL7CpKlCweSTDpJllLqBQpudD1kZs5IILcmGag-iY9rqnXr6hw4H__5-S6qJW54W1MmyaJap6R7zHgjKabkqlrQTSOJ4GxZfe2OIUK5e5eQn5A6zCr4qF3N7pBVOeojspCVMb4O0WfQTiWoKVJu_OdOGNIOBYg6z9ZHBCMU2M8JfXoHp0fvRnurfmIGo50elEHaBlOWfCpzXV1OyiRYn-eqenvYvW6f6v3L4_P2fl8HQttcSzH2LWsGoYBPfMMaKnrGcSvlRPk4YjmSARjdcMYmaAuwoZgNWLSEClIUNavq9je3tD_MkHJndRrAGOWg9O1IW2QVdUwU9OaMzr2FsQtRWxU_uj-bzTeKmnKH</recordid><startdate>20140805</startdate><enddate>20140805</enddate><creator>Wang, Yang</creator><creator>Guan, Shusen</creator><creator>Zhao, Gang</creator><creator>Shi, Pengqiang</creator><creator>Wang, Jinzhong</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>20140805</creationdate><title>Expressions of aquaporin-4, matrix metallo-proteinase-2 and matrix metallo-proteinase-14 in peritumor edematous zone of glioma and clinical implications</title><author>Wang, Yang ; Guan, Shusen ; Zhao, Gang ; Shi, Pengqiang ; Wang, Jinzhong</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p126t-98db643c8ae7f754328b470699f27dd09d1ce425744fe67545204c08612810373</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>chi</language><creationdate>2014</creationdate><topic>Aquaporin 4 - metabolism</topic><topic>Brain Edema - metabolism</topic><topic>Brain Neoplasms - metabolism</topic><topic>Glioma - metabolism</topic><topic>Humans</topic><topic>Matrix Metalloproteinase 14 - metabolism</topic><topic>Matrix Metalloproteinase 2 - metabolism</topic><topic>Matrix Metalloproteinase 9</topic><toplevel>online_resources</toplevel><creatorcontrib>Wang, Yang</creatorcontrib><creatorcontrib>Guan, Shusen</creatorcontrib><creatorcontrib>Zhao, Gang</creatorcontrib><creatorcontrib>Shi, Pengqiang</creatorcontrib><creatorcontrib>Wang, Jinzhong</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Zhong hua yi xue za zhi</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wang, Yang</au><au>Guan, Shusen</au><au>Zhao, Gang</au><au>Shi, Pengqiang</au><au>Wang, Jinzhong</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Expressions of aquaporin-4, matrix metallo-proteinase-2 and matrix metallo-proteinase-14 in peritumor edematous zone of glioma and clinical implications</atitle><jtitle>Zhong hua yi xue za zhi</jtitle><addtitle>Zhonghua Yi Xue Za Zhi</addtitle><date>2014-08-05</date><risdate>2014</risdate><volume>94</volume><issue>29</issue><spage>2290</spage><epage>2292</epage><pages>2290-2292</pages><issn>0376-2491</issn><abstract>To distinguish the expressions of matrix metallo-poteinase and aquaporin in peritumor edematous zone and normal brain tissue for different pathological levels of glioma and explore the relationship of glioma cell invasiveness and brain edema.
The immunohistochemical method of SP was employed to detect the expressions of aquaporin-4 (AQP-4), matrix metallo-proteinase-2 (MMP-2) and matrix metallo-proteinase-14 (MMP-14) in glioma and normal brain tissue. Due to a rarity of glioma Grades I and II, grades I and II glioma were pooled into low malignancy group (LMG) and grades III and IV into high malignancy group (HMG). The software program SPSS 11.0 was used for Kolmogorov-Smirnov test of independent samplets. The differences were detected between normal brain tissue and LMG and HMG. Also the relationship of AQP4, MMP-2 and MMP-14 was analyzed.
With the advancing pathological grades of glioma, the expression of AQP-4, MMP-2 and MMP-14 were higher in positive areas. There were significant deviations among 3 groups.</abstract><cop>China</cop><pmid>25391874</pmid><tpages>3</tpages></addata></record> |
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| ispartof | Zhong hua yi xue za zhi, 2014-08, Vol.94 (29), p.2290-2292 |
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| language | chi |
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| source | MEDLINE; EZB-FREE-00999 freely available EZB journals |
| subjects | Aquaporin 4 - metabolism Brain Edema - metabolism Brain Neoplasms - metabolism Glioma - metabolism Humans Matrix Metalloproteinase 14 - metabolism Matrix Metalloproteinase 2 - metabolism Matrix Metalloproteinase 9 |
| title | Expressions of aquaporin-4, matrix metallo-proteinase-2 and matrix metallo-proteinase-14 in peritumor edematous zone of glioma and clinical implications |
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