Production of pure indinavir free base nanoparticles by a supercritical anti-solvent (SAS) method

Abstract Context: This work investigated the production of pure indinavir free base nanoparticles by a supercritical anti-solvent method to improve the drug dissolution in intestine-like medium. Objective: To increase the dissolution of the drug by means of a supercritical fluid processing method. M...

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Veröffentlicht in:	Drug development and industrial pharmacy 2014-12, Vol.40 (12), p.1607-1615
Hauptverfasser:	Imperiale, Julieta C., Bevilacqua, Gabriela, Rosa, Paulo de Tarso Vieira e, Sosnik, Alejandro
Format:	Artikel
Sprache:	eng
Schlagworte:	Chromatography, Supercritical Fluid - methods Drug dissolution drug solubility HIV Indinavir - chemical synthesis indinavir free base Nanoparticles - chemistry pure drug nanoparticles Solvents supercritical anti-solvent method X-Ray Diffraction
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