Differential effects of ketoconazole, itraconazole and voriconazole on the pharmacokinetics of imatinib and its main metabolite GCP74588 in rat

Abstract The aim of the study was to develop a high performance liquid chromatography method for simultaneous determination of imatinib and CGP74588 in rat serum and study the inhibition effects of ketoconazole, itraconazole and voriconazole on pharmacokinetics of imatinib and CGP74588 in rats. In o...

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Veröffentlicht in:	Drug development and industrial pharmacy 2014-12, Vol.40 (12), p.1616-1622
Hauptverfasser:	Lin, Gaotong, Wang, Chenming, Qiu, Xiangjun, Wang, Zhe, Han, Anyue, Xu, Tao, Kan, Xin, Hu, Guoxin
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antifungal Agents - blood Antifungal Agents - pharmacology Benzamides - blood Benzamides - pharmacology CGP74588 Drug Interactions - physiology HPLC imatinib Imatinib Mesylate itraconazole Itraconazole - blood Itraconazole - pharmacology ketoconazole Ketoconazole - blood Ketoconazole - pharmacology Male Piperazines - blood Piperazines - pharmacology Pyrimidines - blood Pyrimidines - pharmacology Random Allocation Rats Rats, Sprague-Dawley voriconazole Voriconazole - blood Voriconazole - pharmacology
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