Innate immune cells express IL-17A/F in acute generalized exanthematous pustulosis and generalized pustular psoriasis

Acute generalized exanthematous pustulosis (AGEP) and generalized pustular psoriasis (GPP) are rare pustular skin disorders with systemic involvement. IL-17A/F is a proinflammatory cytokine involved in various neutrophilic inflammatory disorders. Here we show that IL-17A/F is highly expressed by inn...

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Veröffentlicht in:	Archives of Dermatological Research 2014-12, Vol.306 (10), p.933-938
Hauptverfasser:	Kakeda, M., Schlapbach, Christoph, Danelon, G., Tang, M. M., Cecchinato, V., Yawalkar, N., Uguccioni, M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute Generalized Exanthematous Pustulosis - genetics Acute Generalized Exanthematous Pustulosis - immunology Acute Generalized Exanthematous Pustulosis - metabolism Adult Aged Aged, 80 and over Case-Control Studies Concise Communication Dermatology Female Humans Immunity, Innate Inflammation Mediators - immunology Inflammation Mediators - metabolism Interleukin-17 - genetics Interleukin-17 - immunology Interleukin-17 - metabolism Male Mast Cells - immunology Mast Cells - metabolism Medicine Medicine & Public Health Middle Aged Neutrophils - immunology Neutrophils - metabolism Psoriasis - genetics Psoriasis - immunology Psoriasis - metabolism RNA, Messenger - metabolism Signal Transduction Skin - immunology Skin - metabolism Young Adult
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Zusammenfassung:	Acute generalized exanthematous pustulosis (AGEP) and generalized pustular psoriasis (GPP) are rare pustular skin disorders with systemic involvement. IL-17A/F is a proinflammatory cytokine involved in various neutrophilic inflammatory disorders. Here we show that IL-17A/F is highly expressed by innate immune cells such as neutrophils and mast cells in both AGEP and GPP.
ISSN:	0340-3696 1432-069X
DOI:	10.1007/s00403-014-1488-0