The complete structure of the large subunit of the mammalian mitochondrial ribosome

The structure of the 39S large mitoribosome subunit is solved by cryo-electron microscopy at an impressive 3.4 Å resolution, revealing the location of 50 ribosomal proteins, the peptidyl transferase centre, the tRNAs within this active site, and the nascent peptide chain within the exit tunnel. Mamm...

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Veröffentlicht in:	Nature (London) 2014-11, Vol.515 (7526), p.283-286
Hauptverfasser:	Greber, Basil J., Boehringer, Daniel, Leibundgut, Marc, Bieri, Philipp, Leitner, Alexander, Schmitz, Nikolaus, Aebersold, Ruedi, Ban, Nenad
Format:	Artikel
Sprache:	eng
Schlagworte:	101/28 101/58 631/1647/527/296 631/337/574/1789 631/45/500 631/535/1258/1259 Animals Binding sites Cross-Linking Reagents Cryoelectron Microscopy Energy conversion Humanities and Social Sciences letter Mammals Mass Spectrometry Mitochondria Mitochondria - chemistry Mitochondria - ultrastructure Mitochondrial Proteins - chemistry Mitochondrial Proteins - metabolism Mitochondrial Proteins - ultrastructure Models, Molecular Molecular Conformation Molecular structure multidisciplinary Peptidyl Transferases - metabolism Polypeptides Proteins Ribonucleic acid Ribosome Subunits, Large - chemistry Ribosome Subunits, Large - genetics Ribosome Subunits, Large - ultrastructure RNA RNA, Ribosomal - chemistry RNA, Ribosomal - metabolism RNA, Ribosomal - ultrastructure Science Sus scrofa - genetics Yeast
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