A pathogenic trace of Tannerella forsythia - shedding of soluble fully active tumor necrosis factor α from the macrophage surface by karilysin

Summary Tannerella forsythia is implicated as a pathogen causing chronic and aggressive periodontitis. However, its virulence factors, including numerous putative proteases, are mostly uncharacterized. Karilysin is a newly described matrix metalloprotease‐like enzyme of T. forsythia. Since pathogen‐...

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Veröffentlicht in:	Molecular oral microbiology 2014-12, Vol.29 (6), p.294-306
Hauptverfasser:	Bryzek, D., Ksiazek, M., Bielecka, E., Karim, A.Y., Potempa, B., Staniec, D., Koziel, J., Potempa, J.
Format:	Artikel
Sprache:	eng
Schlagworte:	ADAM Proteins - metabolism ADAM17 Protein Apoptosis Bacterial Proteins - metabolism Bacteroidetes - enzymology Bacteroidetes - pathogenicity Cell Line Cells, Cultured Cytokines - metabolism Dentistry Humans karilysin macrophages Macrophages - immunology Macrophages - metabolism Matrix Metalloproteinases - metabolism periodontitis Periodontitis - immunology Periodontitis - microbiology Protein Stability Real-Time Polymerase Chain Reaction Tannerella forsythia Tumor Necrosis Factor-alpha - genetics Tumor Necrosis Factor-alpha - metabolism tumor necrosis factor-α Virulence Factors - metabolism
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