Ion channel TRPM8 promotes hypoxic growth of prostate cancer cells via an O2-independent and RACK1-mediated mechanism of HIF-1α stabilization

The growth adaptation of cancer cells to a hypoxic tumour microenvironment is mostly regulated by hypoxia‐induced transcription factor HIF‐1. HIF‐1 transcriptional activity is strictly controlled by protein levels of the HIF‐1α subunit, which is tightly regulated by a well‐characterized O2‐dependent...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	The Journal of pathology 2014-12, Vol.234 (4), p.514-525
Hauptverfasser:	Yu, Shan, Xu, Zhenyu, Zou, Chang, Wu, Dinglan, Wang, Yuliang, Yao, Xiaoqiang, Ng, Chi-Fai, Chan, Franky L
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptation, Physiological - physiology Animals Cell Hypoxia - physiology Cell Line, Tumor Cell Proliferation - physiology Flow Cytometry GTP-Binding Proteins - metabolism Heterografts HIF-1α Humans hypoxia Hypoxia-Inducible Factor 1, alpha Subunit - metabolism Immunoblotting Immunohistochemistry Male Mice Neoplasm Proteins - metabolism Oxygen - metabolism Polymerase Chain Reaction prostate cancer Prostatic Neoplasms - metabolism Prostatic Neoplasms - pathology RACK1 Receptors for Activated C Kinase Receptors, Cell Surface - metabolism transient receptor potential channel TRPM Cation Channels - metabolism Tumor Microenvironment - physiology ubiquitination
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!