First trimester trophoblast and placental bed vascular volume measurements in IVF or IVF/ICSI pregnancies
STUDY QUESTION Are first trimester trophoblast volume (TV) and placental bed vascular volume (PBVV) different in IVF or IVF/ICSI pregnancies in comparison with spontaneously conceived pregnancies? SUMMARY ANSWER Any possible abnormal placentation in IVF or IVF/ICSI pregnancies in comparison with spo...
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| Veröffentlicht in: | Human reproduction (Oxford) 2014-12, Vol.29 (12), p.2644-2649 |
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| creator | Rifouna, M.S. Reus, A.D. Koning, A.H.J. van der Spek, P.J. Exalto, N. Steegers, E.A.P. Laven, J.S.E. |
| description | STUDY QUESTION
Are first trimester trophoblast volume (TV) and placental bed vascular volume (PBVV) different in IVF or IVF/ICSI pregnancies in comparison with spontaneously conceived pregnancies?
SUMMARY ANSWER
Any possible abnormal placentation in IVF or IVF/ICSI pregnancies in comparison with spontaneously conceived pregnancies is not detected by a difference in PBVV or TV at an early gestational age (GA).
WHAT IS KNOWN ALREADY
Assisted reproductive technology pregnancies have been associated with an increased risk of placenta-related adverse pregnancy outcomes. It is unclear whether these effects originate from infertility or from the technique itself.
STUDY DESIGN, SIZE, DURATION
We performed a retrospective cohort study in which 154 pregnant patients qualified for participation.
PARTICIPANTS/MATERIALS, SETTING, METHODS
Out of 154 pregnant patients, 84 conceived spontaneously and 70 conceived after IVF or IVF/ICSI. We determined the TV at 10 weeks GA by Virtual Organ Computer-aided AnaLysis measuring application and the PBVV at 12 weeks GA by the virtual reality operating system of BARCO I-Space in both subgroups. The investigators were blinded to the mode of conception during the measurements. Analysis was limited to singleton pregnancies with only one sac ever detectable.
MAIN RESULTS AND THE ROLE OF CHANCE
There were no differences in TV (mean 42.7, SD 15.9 versus mean 41.2, SD 13.9, P = 0.70) and PBVV (mean 27.6, SD 16.9 versus mean 24.8, SD 19.9, P = 0.20) between IVF or IVF/ICSI pregnancies and spontaneously conceived pregnancies. There was a significant correlation between TV and PBVV (rs = 0.283, P = 0.004).
LIMITATIONS, REASONS FOR CAUTION
The limitations of the present study concern the small size of the study groups.
WIDER IMPLICATIONS OF THE FINDINGS
IVF or IVF/ICSI does not seem to be associated with abnormal placentation.
STUDY FUNDING/COMPETING INTEREST(S)
This study was financially supported by the Erasmus Trustfonds, the Meindert de Hoop foundation and the Fonds NutsOhra. No competing interests are declared. |
| doi_str_mv | 10.1093/humrep/deu273 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1624934745</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><oup_id>10.1093/humrep/deu273</oup_id><sourcerecordid>1624934745</sourcerecordid><originalsourceid>FETCH-LOGICAL-c365t-81172979c7c03e1b6d7e45248e4e89bbfcbfeedbc8da2ab547880ecd1ca6eba53</originalsourceid><addsrcrecordid>eNqFkEtLw0AURgdRbK0u3cos3cTOK5NkKcVqoeDCxzbM48ZGJg9nMoL_3pRUXbq6H5fDd7kHoUtKbigp-HIXGw_90kJkGT9CcyokSRhPyTGaEybzhFJJZ-gshHdCxpjLUzRjKecyI8Uc1evahwEPvm4gDODH1PW7Tjs1blVrce-UgXZQDmuw-FMFE53y-LNzsQHcgArRQzMSAdct3ryucef3Y7lZPW1w7-GtVa2pIZyjk0q5ABeHuUAv67vn1UOyfbzfrG63ieEyHZKc0owVWWEyQzhQLW0GImUiBwF5oXVldAVgtcmtYkqnIstzAsZSoyRolfIFup56e999xPGpsqmDAedUC10MJZVMFFxkYo8mE2p8F4KHquxHD8p_lZSUe7vlZLec7I781aE66gbsL_2j8-92F_t_ur4BXOKH1Q</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1624934745</pqid></control><display><type>article</type><title>First trimester trophoblast and placental bed vascular volume measurements in IVF or IVF/ICSI pregnancies</title><source>Oxford University Press Journals All Titles (1996-Current)</source><source>MEDLINE</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>Alma/SFX Local Collection</source><creator>Rifouna, M.S. ; Reus, A.D. ; Koning, A.H.J. ; van der Spek, P.J. ; Exalto, N. ; Steegers, E.A.P. ; Laven, J.S.E.</creator><creatorcontrib>Rifouna, M.S. ; Reus, A.D. ; Koning, A.H.J. ; van der Spek, P.J. ; Exalto, N. ; Steegers, E.A.P. ; Laven, J.S.E.</creatorcontrib><description>STUDY QUESTION
Are first trimester trophoblast volume (TV) and placental bed vascular volume (PBVV) different in IVF or IVF/ICSI pregnancies in comparison with spontaneously conceived pregnancies?
SUMMARY ANSWER
Any possible abnormal placentation in IVF or IVF/ICSI pregnancies in comparison with spontaneously conceived pregnancies is not detected by a difference in PBVV or TV at an early gestational age (GA).
WHAT IS KNOWN ALREADY
Assisted reproductive technology pregnancies have been associated with an increased risk of placenta-related adverse pregnancy outcomes. It is unclear whether these effects originate from infertility or from the technique itself.
STUDY DESIGN, SIZE, DURATION
We performed a retrospective cohort study in which 154 pregnant patients qualified for participation.
PARTICIPANTS/MATERIALS, SETTING, METHODS
Out of 154 pregnant patients, 84 conceived spontaneously and 70 conceived after IVF or IVF/ICSI. We determined the TV at 10 weeks GA by Virtual Organ Computer-aided AnaLysis measuring application and the PBVV at 12 weeks GA by the virtual reality operating system of BARCO I-Space in both subgroups. The investigators were blinded to the mode of conception during the measurements. Analysis was limited to singleton pregnancies with only one sac ever detectable.
MAIN RESULTS AND THE ROLE OF CHANCE
There were no differences in TV (mean 42.7, SD 15.9 versus mean 41.2, SD 13.9, P = 0.70) and PBVV (mean 27.6, SD 16.9 versus mean 24.8, SD 19.9, P = 0.20) between IVF or IVF/ICSI pregnancies and spontaneously conceived pregnancies. There was a significant correlation between TV and PBVV (rs = 0.283, P = 0.004).
LIMITATIONS, REASONS FOR CAUTION
The limitations of the present study concern the small size of the study groups.
WIDER IMPLICATIONS OF THE FINDINGS
IVF or IVF/ICSI does not seem to be associated with abnormal placentation.
STUDY FUNDING/COMPETING INTEREST(S)
This study was financially supported by the Erasmus Trustfonds, the Meindert de Hoop foundation and the Fonds NutsOhra. No competing interests are declared.</description><identifier>ISSN: 0268-1161</identifier><identifier>EISSN: 1460-2350</identifier><identifier>DOI: 10.1093/humrep/deu273</identifier><identifier>PMID: 25336709</identifier><language>eng</language><publisher>England: Oxford University Press</publisher><subject>Blood Volume ; Female ; Fertilization in Vitro ; Fetal Development ; Humans ; Placenta - blood supply ; Placenta - diagnostic imaging ; Placentation ; Pregnancy ; Pregnancy Trimester, First ; Trophoblasts - diagnostic imaging ; Ultrasonography</subject><ispartof>Human reproduction (Oxford), 2014-12, Vol.29 (12), p.2644-2649</ispartof><rights>The Author 2014. Published by Oxford University Press on behalf of the European Society of Human Reproduction and Embryology. All rights reserved. For Permissions, please email: journals.permissions@oup.com 2014</rights><rights>The Author 2014. Published by Oxford University Press on behalf of the European Society of Human Reproduction and Embryology. All rights reserved. For Permissions, please email: journals.permissions@oup.com.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c365t-81172979c7c03e1b6d7e45248e4e89bbfcbfeedbc8da2ab547880ecd1ca6eba53</citedby><cites>FETCH-LOGICAL-c365t-81172979c7c03e1b6d7e45248e4e89bbfcbfeedbc8da2ab547880ecd1ca6eba53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,1578,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25336709$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Rifouna, M.S.</creatorcontrib><creatorcontrib>Reus, A.D.</creatorcontrib><creatorcontrib>Koning, A.H.J.</creatorcontrib><creatorcontrib>van der Spek, P.J.</creatorcontrib><creatorcontrib>Exalto, N.</creatorcontrib><creatorcontrib>Steegers, E.A.P.</creatorcontrib><creatorcontrib>Laven, J.S.E.</creatorcontrib><title>First trimester trophoblast and placental bed vascular volume measurements in IVF or IVF/ICSI pregnancies</title><title>Human reproduction (Oxford)</title><addtitle>Hum Reprod</addtitle><description>STUDY QUESTION
Are first trimester trophoblast volume (TV) and placental bed vascular volume (PBVV) different in IVF or IVF/ICSI pregnancies in comparison with spontaneously conceived pregnancies?
SUMMARY ANSWER
Any possible abnormal placentation in IVF or IVF/ICSI pregnancies in comparison with spontaneously conceived pregnancies is not detected by a difference in PBVV or TV at an early gestational age (GA).
WHAT IS KNOWN ALREADY
Assisted reproductive technology pregnancies have been associated with an increased risk of placenta-related adverse pregnancy outcomes. It is unclear whether these effects originate from infertility or from the technique itself.
STUDY DESIGN, SIZE, DURATION
We performed a retrospective cohort study in which 154 pregnant patients qualified for participation.
PARTICIPANTS/MATERIALS, SETTING, METHODS
Out of 154 pregnant patients, 84 conceived spontaneously and 70 conceived after IVF or IVF/ICSI. We determined the TV at 10 weeks GA by Virtual Organ Computer-aided AnaLysis measuring application and the PBVV at 12 weeks GA by the virtual reality operating system of BARCO I-Space in both subgroups. The investigators were blinded to the mode of conception during the measurements. Analysis was limited to singleton pregnancies with only one sac ever detectable.
MAIN RESULTS AND THE ROLE OF CHANCE
There were no differences in TV (mean 42.7, SD 15.9 versus mean 41.2, SD 13.9, P = 0.70) and PBVV (mean 27.6, SD 16.9 versus mean 24.8, SD 19.9, P = 0.20) between IVF or IVF/ICSI pregnancies and spontaneously conceived pregnancies. There was a significant correlation between TV and PBVV (rs = 0.283, P = 0.004).
LIMITATIONS, REASONS FOR CAUTION
The limitations of the present study concern the small size of the study groups.
WIDER IMPLICATIONS OF THE FINDINGS
IVF or IVF/ICSI does not seem to be associated with abnormal placentation.
STUDY FUNDING/COMPETING INTEREST(S)
This study was financially supported by the Erasmus Trustfonds, the Meindert de Hoop foundation and the Fonds NutsOhra. No competing interests are declared.</description><subject>Blood Volume</subject><subject>Female</subject><subject>Fertilization in Vitro</subject><subject>Fetal Development</subject><subject>Humans</subject><subject>Placenta - blood supply</subject><subject>Placenta - diagnostic imaging</subject><subject>Placentation</subject><subject>Pregnancy</subject><subject>Pregnancy Trimester, First</subject><subject>Trophoblasts - diagnostic imaging</subject><subject>Ultrasonography</subject><issn>0268-1161</issn><issn>1460-2350</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkEtLw0AURgdRbK0u3cos3cTOK5NkKcVqoeDCxzbM48ZGJg9nMoL_3pRUXbq6H5fDd7kHoUtKbigp-HIXGw_90kJkGT9CcyokSRhPyTGaEybzhFJJZ-gshHdCxpjLUzRjKecyI8Uc1evahwEPvm4gDODH1PW7Tjs1blVrce-UgXZQDmuw-FMFE53y-LNzsQHcgArRQzMSAdct3ryucef3Y7lZPW1w7-GtVa2pIZyjk0q5ABeHuUAv67vn1UOyfbzfrG63ieEyHZKc0owVWWEyQzhQLW0GImUiBwF5oXVldAVgtcmtYkqnIstzAsZSoyRolfIFup56e999xPGpsqmDAedUC10MJZVMFFxkYo8mE2p8F4KHquxHD8p_lZSUe7vlZLec7I781aE66gbsL_2j8-92F_t_ur4BXOKH1Q</recordid><startdate>20141201</startdate><enddate>20141201</enddate><creator>Rifouna, M.S.</creator><creator>Reus, A.D.</creator><creator>Koning, A.H.J.</creator><creator>van der Spek, P.J.</creator><creator>Exalto, N.</creator><creator>Steegers, E.A.P.</creator><creator>Laven, J.S.E.</creator><general>Oxford University Press</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20141201</creationdate><title>First trimester trophoblast and placental bed vascular volume measurements in IVF or IVF/ICSI pregnancies</title><author>Rifouna, M.S. ; Reus, A.D. ; Koning, A.H.J. ; van der Spek, P.J. ; Exalto, N. ; Steegers, E.A.P. ; Laven, J.S.E.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c365t-81172979c7c03e1b6d7e45248e4e89bbfcbfeedbc8da2ab547880ecd1ca6eba53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Blood Volume</topic><topic>Female</topic><topic>Fertilization in Vitro</topic><topic>Fetal Development</topic><topic>Humans</topic><topic>Placenta - blood supply</topic><topic>Placenta - diagnostic imaging</topic><topic>Placentation</topic><topic>Pregnancy</topic><topic>Pregnancy Trimester, First</topic><topic>Trophoblasts - diagnostic imaging</topic><topic>Ultrasonography</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Rifouna, M.S.</creatorcontrib><creatorcontrib>Reus, A.D.</creatorcontrib><creatorcontrib>Koning, A.H.J.</creatorcontrib><creatorcontrib>van der Spek, P.J.</creatorcontrib><creatorcontrib>Exalto, N.</creatorcontrib><creatorcontrib>Steegers, E.A.P.</creatorcontrib><creatorcontrib>Laven, J.S.E.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Human reproduction (Oxford)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Rifouna, M.S.</au><au>Reus, A.D.</au><au>Koning, A.H.J.</au><au>van der Spek, P.J.</au><au>Exalto, N.</au><au>Steegers, E.A.P.</au><au>Laven, J.S.E.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>First trimester trophoblast and placental bed vascular volume measurements in IVF or IVF/ICSI pregnancies</atitle><jtitle>Human reproduction (Oxford)</jtitle><addtitle>Hum Reprod</addtitle><date>2014-12-01</date><risdate>2014</risdate><volume>29</volume><issue>12</issue><spage>2644</spage><epage>2649</epage><pages>2644-2649</pages><issn>0268-1161</issn><eissn>1460-2350</eissn><abstract>STUDY QUESTION
Are first trimester trophoblast volume (TV) and placental bed vascular volume (PBVV) different in IVF or IVF/ICSI pregnancies in comparison with spontaneously conceived pregnancies?
SUMMARY ANSWER
Any possible abnormal placentation in IVF or IVF/ICSI pregnancies in comparison with spontaneously conceived pregnancies is not detected by a difference in PBVV or TV at an early gestational age (GA).
WHAT IS KNOWN ALREADY
Assisted reproductive technology pregnancies have been associated with an increased risk of placenta-related adverse pregnancy outcomes. It is unclear whether these effects originate from infertility or from the technique itself.
STUDY DESIGN, SIZE, DURATION
We performed a retrospective cohort study in which 154 pregnant patients qualified for participation.
PARTICIPANTS/MATERIALS, SETTING, METHODS
Out of 154 pregnant patients, 84 conceived spontaneously and 70 conceived after IVF or IVF/ICSI. We determined the TV at 10 weeks GA by Virtual Organ Computer-aided AnaLysis measuring application and the PBVV at 12 weeks GA by the virtual reality operating system of BARCO I-Space in both subgroups. The investigators were blinded to the mode of conception during the measurements. Analysis was limited to singleton pregnancies with only one sac ever detectable.
MAIN RESULTS AND THE ROLE OF CHANCE
There were no differences in TV (mean 42.7, SD 15.9 versus mean 41.2, SD 13.9, P = 0.70) and PBVV (mean 27.6, SD 16.9 versus mean 24.8, SD 19.9, P = 0.20) between IVF or IVF/ICSI pregnancies and spontaneously conceived pregnancies. There was a significant correlation between TV and PBVV (rs = 0.283, P = 0.004).
LIMITATIONS, REASONS FOR CAUTION
The limitations of the present study concern the small size of the study groups.
WIDER IMPLICATIONS OF THE FINDINGS
IVF or IVF/ICSI does not seem to be associated with abnormal placentation.
STUDY FUNDING/COMPETING INTEREST(S)
This study was financially supported by the Erasmus Trustfonds, the Meindert de Hoop foundation and the Fonds NutsOhra. No competing interests are declared.</abstract><cop>England</cop><pub>Oxford University Press</pub><pmid>25336709</pmid><doi>10.1093/humrep/deu273</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
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| ispartof | Human reproduction (Oxford), 2014-12, Vol.29 (12), p.2644-2649 |
| issn | 0268-1161 1460-2350 |
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| source | Oxford University Press Journals All Titles (1996-Current); MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | Blood Volume Female Fertilization in Vitro Fetal Development Humans Placenta - blood supply Placenta - diagnostic imaging Placentation Pregnancy Pregnancy Trimester, First Trophoblasts - diagnostic imaging Ultrasonography |
| title | First trimester trophoblast and placental bed vascular volume measurements in IVF or IVF/ICSI pregnancies |
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