Vitamin D Receptor ApaI a Allele Is Associated with Better Childhood Asthma Control and Improvement in Ability for Daily Activities
Vitamin D levels have been suggested as a marker of disease severity in asthmatic children. Our aim was to investigate possible associations between the vitamin D receptor (VDR) FokI, BsmI , ApaI, and TaqI polymorphisms and asthma susceptibility and control in children. 127 Greek children with asthm...
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| Veröffentlicht in: | Omics (Larchmont, N.Y.) N.Y.), 2014-11, Vol.18 (11), p.673-681 |
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| creator | Iordanidou, Maria Paraskakis, Emmanouil Giannakopoulou, Efstathia Tavridou, Anna Gentile, Giovanna Borro, Marina Simmaco, Maurizio Chatzimichael, Athanasios Bush, Andrew Manolopoulos, Vangelis G. |
| description | Vitamin D levels have been suggested as a marker of disease severity in asthmatic children. Our aim was to investigate possible associations between the vitamin D receptor (VDR)
FokI, BsmI
,
ApaI,
and
TaqI
polymorphisms and asthma susceptibility and control in children. 127 Greek children with asthma and 91 healthy controls were genotyped for VDR
FokI
,
BsmI ApaI,
and
TaqI
polymorphisms using Sequenom MassARRAY iPLEX platform. Asthma control was assessed according to the Global Initiative for Asthma guidelines (GINA) and Childhood Asthma Control Test (C-ACT) and, for the first time, tested for its possible association with VDR SNPs. Asthmatic children were grouped as “controlled (
n
=49)”, “partially controlled (
n
=38),” and “uncontrolled (
n
=40),” according to GINA classification. No association was found between VDR polymorphisms and asthma prevalence. Asthmatic children with the VDR
ApaI
aa genotype had significantly higher C-ACT score compared with asthmatic children carrying the AA/AC VDR
ApaI
genotypes (
p
=0.011). The frequency of VDR
ApaI
aa genotype was significantly higher in controlled asthma group (
n
=92) than uncontrolled asthma group (
n
=35), according to C-ACT (24.5% vs 0.0%,
p |
| doi_str_mv | 10.1089/omi.2014.0023 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1624933420</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1624933420</sourcerecordid><originalsourceid>FETCH-LOGICAL-c337t-525f8ff2dca1edae71aa767ac5e3e8a5a1ca76c498bdc9a29d87f00d99a6b0413</originalsourceid><addsrcrecordid>eNqFkM9r2zAUgMXoWNp0x12Ljr041Q87to9esq2BwGCsvZpn6ZmoyFYmKSk57x-vTLJde3p64uPj8RHyhbMFZ1X94AazEIznC8aE_ECueVGUWcUZu5recpkJydmM3ITwkgi-FPITmYlCFlLK8pr8fTYRBjPSNf2FCvfRedrsYUOBNtaiRboJtAnBKQMRNX01cUe_Yozo6WpnrN45pxMQdwPQlRujd5bCqOlm2Ht3xAHHSJO-6Yw18UT75F-DsSfaqGiOJhoMt-RjDzbg58uck6fv336vHrPtzx-bVbPNVDo1ZoUo-qrvhVbAUQOWHKBclqAKlFhBAVylXeV11WlVg6h1VfaM6bqGZcdyLufk_uxNl_05YIjtYIJCa2FEdwhtipPXUuaCJTQ7o8q7EDz27d6bAfyp5aydurepezt1b6fuib-7qA_dgPo__S90AuQZmL5hHK3BDn18R_sG6_CQzQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1624933420</pqid></control><display><type>article</type><title>Vitamin D Receptor ApaI a Allele Is Associated with Better Childhood Asthma Control and Improvement in Ability for Daily Activities</title><source>MEDLINE</source><source>Alma/SFX Local Collection</source><creator>Iordanidou, Maria ; Paraskakis, Emmanouil ; Giannakopoulou, Efstathia ; Tavridou, Anna ; Gentile, Giovanna ; Borro, Marina ; Simmaco, Maurizio ; Chatzimichael, Athanasios ; Bush, Andrew ; Manolopoulos, Vangelis G.</creator><creatorcontrib>Iordanidou, Maria ; Paraskakis, Emmanouil ; Giannakopoulou, Efstathia ; Tavridou, Anna ; Gentile, Giovanna ; Borro, Marina ; Simmaco, Maurizio ; Chatzimichael, Athanasios ; Bush, Andrew ; Manolopoulos, Vangelis G.</creatorcontrib><description>Vitamin D levels have been suggested as a marker of disease severity in asthmatic children. Our aim was to investigate possible associations between the vitamin D receptor (VDR)
FokI, BsmI
,
ApaI,
and
TaqI
polymorphisms and asthma susceptibility and control in children. 127 Greek children with asthma and 91 healthy controls were genotyped for VDR
FokI
,
BsmI ApaI,
and
TaqI
polymorphisms using Sequenom MassARRAY iPLEX platform. Asthma control was assessed according to the Global Initiative for Asthma guidelines (GINA) and Childhood Asthma Control Test (C-ACT) and, for the first time, tested for its possible association with VDR SNPs. Asthmatic children were grouped as “controlled (
n
=49)”, “partially controlled (
n
=38),” and “uncontrolled (
n
=40),” according to GINA classification. No association was found between VDR polymorphisms and asthma prevalence. Asthmatic children with the VDR
ApaI
aa genotype had significantly higher C-ACT score compared with asthmatic children carrying the AA/AC VDR
ApaI
genotypes (
p
=0.011). The frequency of VDR
ApaI
aa genotype was significantly higher in controlled asthma group (
n
=92) than uncontrolled asthma group (
n
=35), according to C-ACT (24.5% vs 0.0%,
p
<0.001) and GINA (32.7% vs 7.5%,
p
=0.001). Also, VDR
ApaI
aa genotype was negatively associated with limitation in daily activities because of asthma (
p
=0.004). VDR
ApaI
aa genotype was positively associated with well-controlled asthma according to GINA and C-ACT questionnaire and negatively associated with decreased limitation in daily activities in asthmatic children, further supporting the importance of Vitamin D pathway in asthma.</description><identifier>ISSN: 1536-2310</identifier><identifier>EISSN: 1557-8100</identifier><identifier>DOI: 10.1089/omi.2014.0023</identifier><identifier>PMID: 25353337</identifier><language>eng</language><publisher>United States: Mary Ann Liebert, Inc</publisher><subject>Activities of Daily Living ; Asthma - genetics ; Asthma - prevention & control ; Case-Control Studies ; Child ; Child, Preschool ; Female ; Gene Frequency ; Genetic Predisposition to Disease ; Genotype ; Humans ; Male ; Original Articles ; Polymorphism, Genetic ; Receptors, Calcitriol - genetics ; Vitamin D - metabolism</subject><ispartof>Omics (Larchmont, N.Y.), 2014-11, Vol.18 (11), p.673-681</ispartof><rights>2014, Mary Ann Liebert, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c337t-525f8ff2dca1edae71aa767ac5e3e8a5a1ca76c498bdc9a29d87f00d99a6b0413</citedby><cites>FETCH-LOGICAL-c337t-525f8ff2dca1edae71aa767ac5e3e8a5a1ca76c498bdc9a29d87f00d99a6b0413</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25353337$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Iordanidou, Maria</creatorcontrib><creatorcontrib>Paraskakis, Emmanouil</creatorcontrib><creatorcontrib>Giannakopoulou, Efstathia</creatorcontrib><creatorcontrib>Tavridou, Anna</creatorcontrib><creatorcontrib>Gentile, Giovanna</creatorcontrib><creatorcontrib>Borro, Marina</creatorcontrib><creatorcontrib>Simmaco, Maurizio</creatorcontrib><creatorcontrib>Chatzimichael, Athanasios</creatorcontrib><creatorcontrib>Bush, Andrew</creatorcontrib><creatorcontrib>Manolopoulos, Vangelis G.</creatorcontrib><title>Vitamin D Receptor ApaI a Allele Is Associated with Better Childhood Asthma Control and Improvement in Ability for Daily Activities</title><title>Omics (Larchmont, N.Y.)</title><addtitle>OMICS</addtitle><description>Vitamin D levels have been suggested as a marker of disease severity in asthmatic children. Our aim was to investigate possible associations between the vitamin D receptor (VDR)
FokI, BsmI
,
ApaI,
and
TaqI
polymorphisms and asthma susceptibility and control in children. 127 Greek children with asthma and 91 healthy controls were genotyped for VDR
FokI
,
BsmI ApaI,
and
TaqI
polymorphisms using Sequenom MassARRAY iPLEX platform. Asthma control was assessed according to the Global Initiative for Asthma guidelines (GINA) and Childhood Asthma Control Test (C-ACT) and, for the first time, tested for its possible association with VDR SNPs. Asthmatic children were grouped as “controlled (
n
=49)”, “partially controlled (
n
=38),” and “uncontrolled (
n
=40),” according to GINA classification. No association was found between VDR polymorphisms and asthma prevalence. Asthmatic children with the VDR
ApaI
aa genotype had significantly higher C-ACT score compared with asthmatic children carrying the AA/AC VDR
ApaI
genotypes (
p
=0.011). The frequency of VDR
ApaI
aa genotype was significantly higher in controlled asthma group (
n
=92) than uncontrolled asthma group (
n
=35), according to C-ACT (24.5% vs 0.0%,
p
<0.001) and GINA (32.7% vs 7.5%,
p
=0.001). Also, VDR
ApaI
aa genotype was negatively associated with limitation in daily activities because of asthma (
p
=0.004). VDR
ApaI
aa genotype was positively associated with well-controlled asthma according to GINA and C-ACT questionnaire and negatively associated with decreased limitation in daily activities in asthmatic children, further supporting the importance of Vitamin D pathway in asthma.</description><subject>Activities of Daily Living</subject><subject>Asthma - genetics</subject><subject>Asthma - prevention & control</subject><subject>Case-Control Studies</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Female</subject><subject>Gene Frequency</subject><subject>Genetic Predisposition to Disease</subject><subject>Genotype</subject><subject>Humans</subject><subject>Male</subject><subject>Original Articles</subject><subject>Polymorphism, Genetic</subject><subject>Receptors, Calcitriol - genetics</subject><subject>Vitamin D - metabolism</subject><issn>1536-2310</issn><issn>1557-8100</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkM9r2zAUgMXoWNp0x12Ljr041Q87to9esq2BwGCsvZpn6ZmoyFYmKSk57x-vTLJde3p64uPj8RHyhbMFZ1X94AazEIznC8aE_ECueVGUWcUZu5recpkJydmM3ITwkgi-FPITmYlCFlLK8pr8fTYRBjPSNf2FCvfRedrsYUOBNtaiRboJtAnBKQMRNX01cUe_Yozo6WpnrN45pxMQdwPQlRujd5bCqOlm2Ht3xAHHSJO-6Yw18UT75F-DsSfaqGiOJhoMt-RjDzbg58uck6fv336vHrPtzx-bVbPNVDo1ZoUo-qrvhVbAUQOWHKBclqAKlFhBAVylXeV11WlVg6h1VfaM6bqGZcdyLufk_uxNl_05YIjtYIJCa2FEdwhtipPXUuaCJTQ7o8q7EDz27d6bAfyp5aydurepezt1b6fuib-7qA_dgPo__S90AuQZmL5hHK3BDn18R_sG6_CQzQ</recordid><startdate>20141101</startdate><enddate>20141101</enddate><creator>Iordanidou, Maria</creator><creator>Paraskakis, Emmanouil</creator><creator>Giannakopoulou, Efstathia</creator><creator>Tavridou, Anna</creator><creator>Gentile, Giovanna</creator><creator>Borro, Marina</creator><creator>Simmaco, Maurizio</creator><creator>Chatzimichael, Athanasios</creator><creator>Bush, Andrew</creator><creator>Manolopoulos, Vangelis G.</creator><general>Mary Ann Liebert, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20141101</creationdate><title>Vitamin D Receptor ApaI a Allele Is Associated with Better Childhood Asthma Control and Improvement in Ability for Daily Activities</title><author>Iordanidou, Maria ; Paraskakis, Emmanouil ; Giannakopoulou, Efstathia ; Tavridou, Anna ; Gentile, Giovanna ; Borro, Marina ; Simmaco, Maurizio ; Chatzimichael, Athanasios ; Bush, Andrew ; Manolopoulos, Vangelis G.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c337t-525f8ff2dca1edae71aa767ac5e3e8a5a1ca76c498bdc9a29d87f00d99a6b0413</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Activities of Daily Living</topic><topic>Asthma - genetics</topic><topic>Asthma - prevention & control</topic><topic>Case-Control Studies</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Female</topic><topic>Gene Frequency</topic><topic>Genetic Predisposition to Disease</topic><topic>Genotype</topic><topic>Humans</topic><topic>Male</topic><topic>Original Articles</topic><topic>Polymorphism, Genetic</topic><topic>Receptors, Calcitriol - genetics</topic><topic>Vitamin D - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Iordanidou, Maria</creatorcontrib><creatorcontrib>Paraskakis, Emmanouil</creatorcontrib><creatorcontrib>Giannakopoulou, Efstathia</creatorcontrib><creatorcontrib>Tavridou, Anna</creatorcontrib><creatorcontrib>Gentile, Giovanna</creatorcontrib><creatorcontrib>Borro, Marina</creatorcontrib><creatorcontrib>Simmaco, Maurizio</creatorcontrib><creatorcontrib>Chatzimichael, Athanasios</creatorcontrib><creatorcontrib>Bush, Andrew</creatorcontrib><creatorcontrib>Manolopoulos, Vangelis G.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Omics (Larchmont, N.Y.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Iordanidou, Maria</au><au>Paraskakis, Emmanouil</au><au>Giannakopoulou, Efstathia</au><au>Tavridou, Anna</au><au>Gentile, Giovanna</au><au>Borro, Marina</au><au>Simmaco, Maurizio</au><au>Chatzimichael, Athanasios</au><au>Bush, Andrew</au><au>Manolopoulos, Vangelis G.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Vitamin D Receptor ApaI a Allele Is Associated with Better Childhood Asthma Control and Improvement in Ability for Daily Activities</atitle><jtitle>Omics (Larchmont, N.Y.)</jtitle><addtitle>OMICS</addtitle><date>2014-11-01</date><risdate>2014</risdate><volume>18</volume><issue>11</issue><spage>673</spage><epage>681</epage><pages>673-681</pages><issn>1536-2310</issn><eissn>1557-8100</eissn><abstract>Vitamin D levels have been suggested as a marker of disease severity in asthmatic children. Our aim was to investigate possible associations between the vitamin D receptor (VDR)
FokI, BsmI
,
ApaI,
and
TaqI
polymorphisms and asthma susceptibility and control in children. 127 Greek children with asthma and 91 healthy controls were genotyped for VDR
FokI
,
BsmI ApaI,
and
TaqI
polymorphisms using Sequenom MassARRAY iPLEX platform. Asthma control was assessed according to the Global Initiative for Asthma guidelines (GINA) and Childhood Asthma Control Test (C-ACT) and, for the first time, tested for its possible association with VDR SNPs. Asthmatic children were grouped as “controlled (
n
=49)”, “partially controlled (
n
=38),” and “uncontrolled (
n
=40),” according to GINA classification. No association was found between VDR polymorphisms and asthma prevalence. Asthmatic children with the VDR
ApaI
aa genotype had significantly higher C-ACT score compared with asthmatic children carrying the AA/AC VDR
ApaI
genotypes (
p
=0.011). The frequency of VDR
ApaI
aa genotype was significantly higher in controlled asthma group (
n
=92) than uncontrolled asthma group (
n
=35), according to C-ACT (24.5% vs 0.0%,
p
<0.001) and GINA (32.7% vs 7.5%,
p
=0.001). Also, VDR
ApaI
aa genotype was negatively associated with limitation in daily activities because of asthma (
p
=0.004). VDR
ApaI
aa genotype was positively associated with well-controlled asthma according to GINA and C-ACT questionnaire and negatively associated with decreased limitation in daily activities in asthmatic children, further supporting the importance of Vitamin D pathway in asthma.</abstract><cop>United States</cop><pub>Mary Ann Liebert, Inc</pub><pmid>25353337</pmid><doi>10.1089/omi.2014.0023</doi><tpages>9</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1536-2310 |
| ispartof | Omics (Larchmont, N.Y.), 2014-11, Vol.18 (11), p.673-681 |
| issn | 1536-2310 1557-8100 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1624933420 |
| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Activities of Daily Living Asthma - genetics Asthma - prevention & control Case-Control Studies Child Child, Preschool Female Gene Frequency Genetic Predisposition to Disease Genotype Humans Male Original Articles Polymorphism, Genetic Receptors, Calcitriol - genetics Vitamin D - metabolism |
| title | Vitamin D Receptor ApaI a Allele Is Associated with Better Childhood Asthma Control and Improvement in Ability for Daily Activities |
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