Rat p53 Gene Mutations in Primary Zymbal Gland Tumors Induced by 2-Amino-3-Methylimidazo[4,5-f]Quinoline, a Food Mutagen

There are reports of p53 gene mutations in various human cancers but not in rat tumor cell lines or rat primary tumor tissue. We found a p53 gene mutation in a cell line of a spontaneous squamous cell carcinoma of the rat Zymbal gland, SCC131, at codon 171 by direct sequencing of cDNA fragments ampl...

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