Urinary Mercury in Twelve Cases of Cutaneous Mercurous Chloride (Calomel) Exposure: Effect of Sodium 2,3-Dimercaptopropane-1-sulfonate (DMPS) Therapy
Abstract Objective: To evaluate clinical symptoms and urinary mercury before and after chelation therapy in subjects with chronic cutaneous mercurous chloride (HgCl; calomel) exposure. Subjects: Twelve women from 19-45 years who had used a facial cream which contained HgCl (5.9%) for 2 to 10 years....
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| Veröffentlicht in: | Clinical toxicology (Philadelphia, Pa.) Pa.), 1997, Vol.35 (6), p.653-655 |
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| container_title | Clinical toxicology (Philadelphia, Pa.) |
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| creator | Garza-Ocañas, Lourdes Torres-Alanís, Oscar Piñeyro-López, Alfredo |
| description | Abstract
Objective: To evaluate clinical symptoms and urinary mercury before and after chelation therapy in subjects with chronic cutaneous mercurous chloride (HgCl; calomel) exposure. Subjects: Twelve women from 19-45 years who had used a facial cream which contained HgCl (5.9%) for 2 to 10 years. Design: Twenty-four hour urine samples were collected for basal urine mercury. All the subjects received a 5-day cycle of oral sodium 2,3-dimercaptopropane-1-sulfonate (Dimaval capsules 100 mg) 200 mg/d on an outpatient basis. The urine mercury excretion was monitored 24 hours after the first dose and 72 hours after the last dose in eight subjects. Result: Exanthem and tremor were detected in two of 12 subjects. The range of urine mercury was 180 to 1876 μg/g creatinine. A significant increase in the urinary mercury excretion was observed in the first 24 hours after beginning sodium 2,3-dimercaptopropane-1-sulfonate. Conclusion: Chronic topical application of 5.9% HgCl cream was associated with clinical mercurialism in two subjects and with high urinary mercury level in all the cases. Sodium 2,3-dimercaptopropane-1-sulfonate was effective in increasing urine mercury. |
| doi_str_mv | 10.3109/15563659709001249 |
| format | Article |
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Objective: To evaluate clinical symptoms and urinary mercury before and after chelation therapy in subjects with chronic cutaneous mercurous chloride (HgCl; calomel) exposure. Subjects: Twelve women from 19-45 years who had used a facial cream which contained HgCl (5.9%) for 2 to 10 years. Design: Twenty-four hour urine samples were collected for basal urine mercury. All the subjects received a 5-day cycle of oral sodium 2,3-dimercaptopropane-1-sulfonate (Dimaval capsules 100 mg) 200 mg/d on an outpatient basis. The urine mercury excretion was monitored 24 hours after the first dose and 72 hours after the last dose in eight subjects. Result: Exanthem and tremor were detected in two of 12 subjects. The range of urine mercury was 180 to 1876 μg/g creatinine. A significant increase in the urinary mercury excretion was observed in the first 24 hours after beginning sodium 2,3-dimercaptopropane-1-sulfonate. Conclusion: Chronic topical application of 5.9% HgCl cream was associated with clinical mercurialism in two subjects and with high urinary mercury level in all the cases. Sodium 2,3-dimercaptopropane-1-sulfonate was effective in increasing urine mercury.</description><identifier>ISSN: 1556-3650</identifier><identifier>ISSN: 0731-3810</identifier><identifier>EISSN: 1556-9519</identifier><identifier>DOI: 10.3109/15563659709001249</identifier><identifier>PMID: 9365436</identifier><language>eng</language><publisher>United States: Informa UK Ltd</publisher><subject>Administration, Oral ; Adult ; Chelating Agents - administration & dosage ; Chelating Agents - therapeutic use ; Face ; Female ; Humans ; Mercury - urine ; Mercury Compounds - poisoning ; Mercury Poisoning - drug therapy ; Mercury Poisoning - urine ; Middle Aged ; Ointments - poisoning ; Skin Absorption - drug effects ; Spectrophotometry, Atomic ; Unithiol - administration & dosage ; Unithiol - therapeutic use</subject><ispartof>Clinical toxicology (Philadelphia, Pa.), 1997, Vol.35 (6), p.653-655</ispartof><rights>1997 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted 1997</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c432t-caa41045edaeb5d3fc3dc727da13c2220c4f2d2f16a39584852ba7278af57dae3</citedby><cites>FETCH-LOGICAL-c432t-caa41045edaeb5d3fc3dc727da13c2220c4f2d2f16a39584852ba7278af57dae3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.tandfonline.com/doi/pdf/10.3109/15563659709001249$$EPDF$$P50$$Ginformahealthcare$$H</linktopdf><linktohtml>$$Uhttps://www.tandfonline.com/doi/full/10.3109/15563659709001249$$EHTML$$P50$$Ginformahealthcare$$H</linktohtml><link.rule.ids>314,780,784,4024,27923,27924,27925,59647,59753,60436,60542,61221,61256,61402,61437</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9365436$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Garza-Ocañas, Lourdes</creatorcontrib><creatorcontrib>Torres-Alanís, Oscar</creatorcontrib><creatorcontrib>Piñeyro-López, Alfredo</creatorcontrib><title>Urinary Mercury in Twelve Cases of Cutaneous Mercurous Chloride (Calomel) Exposure: Effect of Sodium 2,3-Dimercaptopropane-1-sulfonate (DMPS) Therapy</title><title>Clinical toxicology (Philadelphia, Pa.)</title><addtitle>J Toxicol Clin Toxicol</addtitle><description>Abstract
Objective: To evaluate clinical symptoms and urinary mercury before and after chelation therapy in subjects with chronic cutaneous mercurous chloride (HgCl; calomel) exposure. Subjects: Twelve women from 19-45 years who had used a facial cream which contained HgCl (5.9%) for 2 to 10 years. Design: Twenty-four hour urine samples were collected for basal urine mercury. All the subjects received a 5-day cycle of oral sodium 2,3-dimercaptopropane-1-sulfonate (Dimaval capsules 100 mg) 200 mg/d on an outpatient basis. The urine mercury excretion was monitored 24 hours after the first dose and 72 hours after the last dose in eight subjects. Result: Exanthem and tremor were detected in two of 12 subjects. The range of urine mercury was 180 to 1876 μg/g creatinine. A significant increase in the urinary mercury excretion was observed in the first 24 hours after beginning sodium 2,3-dimercaptopropane-1-sulfonate. Conclusion: Chronic topical application of 5.9% HgCl cream was associated with clinical mercurialism in two subjects and with high urinary mercury level in all the cases. Sodium 2,3-dimercaptopropane-1-sulfonate was effective in increasing urine mercury.</description><subject>Administration, Oral</subject><subject>Adult</subject><subject>Chelating Agents - administration & dosage</subject><subject>Chelating Agents - therapeutic use</subject><subject>Face</subject><subject>Female</subject><subject>Humans</subject><subject>Mercury - urine</subject><subject>Mercury Compounds - poisoning</subject><subject>Mercury Poisoning - drug therapy</subject><subject>Mercury Poisoning - urine</subject><subject>Middle Aged</subject><subject>Ointments - poisoning</subject><subject>Skin Absorption - drug effects</subject><subject>Spectrophotometry, Atomic</subject><subject>Unithiol - administration & dosage</subject><subject>Unithiol - therapeutic use</subject><issn>1556-3650</issn><issn>0731-3810</issn><issn>1556-9519</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9Ud1q1UAQXsRSa_UBvBD2Slowur85ifVG0lMVWhR6eh3mbGY5KZts3E2s50F8XzecIIjo1Qzz_TDzDSEvOHsjOSvfcq1zmetyxUrGuFDlI3Iyz7JS8_Lx0icCe0KexnjPmCxUyY_JcZmGSuYn5OddaHsIe3qDwUyptj3dPKD7jrSCiJF6S6tphB79FBfS3FU750PbID2rwPkO3Tld_xh8nAK-o2tr0Yyz9NY37dRR8Vpml22X1DCMfgh-SIYZz-LkrO9hTDaXN19vz-lmhwGG_TNyZMFFfL7UU3J3td5Un7LrLx8_Vx-uM6OkGDMDoDhTGhvArW6kNbIxK7FqgEsjhGBGWdEIy3OQpS5UocUWEl6A1YmE8pS8Ovimlb5NGMe6a6NB5w731jwXSmtdJCI_EE3wMQa09RDaLuVWc1bPr6j_ekXSvFzMp22HzW_Fkn3C3x_wtrc-dPDgg2vqEfYpWRugN22crf9tf_GHfIfgxp2BgPW9n0KfcvvPcr8AXvCqcg</recordid><startdate>1997</startdate><enddate>1997</enddate><creator>Garza-Ocañas, Lourdes</creator><creator>Torres-Alanís, Oscar</creator><creator>Piñeyro-López, Alfredo</creator><general>Informa UK Ltd</general><general>Taylor & Francis</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U7</scope><scope>C1K</scope></search><sort><creationdate>1997</creationdate><title>Urinary Mercury in Twelve Cases of Cutaneous Mercurous Chloride (Calomel) Exposure: Effect of Sodium 2,3-Dimercaptopropane-1-sulfonate (DMPS) Therapy</title><author>Garza-Ocañas, Lourdes ; Torres-Alanís, Oscar ; Piñeyro-López, Alfredo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c432t-caa41045edaeb5d3fc3dc727da13c2220c4f2d2f16a39584852ba7278af57dae3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1997</creationdate><topic>Administration, Oral</topic><topic>Adult</topic><topic>Chelating Agents - administration & dosage</topic><topic>Chelating Agents - therapeutic use</topic><topic>Face</topic><topic>Female</topic><topic>Humans</topic><topic>Mercury - urine</topic><topic>Mercury Compounds - poisoning</topic><topic>Mercury Poisoning - drug therapy</topic><topic>Mercury Poisoning - urine</topic><topic>Middle Aged</topic><topic>Ointments - poisoning</topic><topic>Skin Absorption - drug effects</topic><topic>Spectrophotometry, Atomic</topic><topic>Unithiol - administration & dosage</topic><topic>Unithiol - therapeutic use</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Garza-Ocañas, Lourdes</creatorcontrib><creatorcontrib>Torres-Alanís, Oscar</creatorcontrib><creatorcontrib>Piñeyro-López, Alfredo</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>Clinical toxicology (Philadelphia, Pa.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Garza-Ocañas, Lourdes</au><au>Torres-Alanís, Oscar</au><au>Piñeyro-López, Alfredo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Urinary Mercury in Twelve Cases of Cutaneous Mercurous Chloride (Calomel) Exposure: Effect of Sodium 2,3-Dimercaptopropane-1-sulfonate (DMPS) Therapy</atitle><jtitle>Clinical toxicology (Philadelphia, Pa.)</jtitle><addtitle>J Toxicol Clin Toxicol</addtitle><date>1997</date><risdate>1997</risdate><volume>35</volume><issue>6</issue><spage>653</spage><epage>655</epage><pages>653-655</pages><issn>1556-3650</issn><issn>0731-3810</issn><eissn>1556-9519</eissn><abstract>Abstract
Objective: To evaluate clinical symptoms and urinary mercury before and after chelation therapy in subjects with chronic cutaneous mercurous chloride (HgCl; calomel) exposure. Subjects: Twelve women from 19-45 years who had used a facial cream which contained HgCl (5.9%) for 2 to 10 years. Design: Twenty-four hour urine samples were collected for basal urine mercury. All the subjects received a 5-day cycle of oral sodium 2,3-dimercaptopropane-1-sulfonate (Dimaval capsules 100 mg) 200 mg/d on an outpatient basis. The urine mercury excretion was monitored 24 hours after the first dose and 72 hours after the last dose in eight subjects. Result: Exanthem and tremor were detected in two of 12 subjects. The range of urine mercury was 180 to 1876 μg/g creatinine. A significant increase in the urinary mercury excretion was observed in the first 24 hours after beginning sodium 2,3-dimercaptopropane-1-sulfonate. Conclusion: Chronic topical application of 5.9% HgCl cream was associated with clinical mercurialism in two subjects and with high urinary mercury level in all the cases. Sodium 2,3-dimercaptopropane-1-sulfonate was effective in increasing urine mercury.</abstract><cop>United States</cop><pub>Informa UK Ltd</pub><pmid>9365436</pmid><doi>10.3109/15563659709001249</doi><tpages>3</tpages></addata></record> |
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| source | MEDLINE; Taylor & Francis Online; Taylor & Francis Medical Library - CRKN |
| subjects | Administration, Oral Adult Chelating Agents - administration & dosage Chelating Agents - therapeutic use Face Female Humans Mercury - urine Mercury Compounds - poisoning Mercury Poisoning - drug therapy Mercury Poisoning - urine Middle Aged Ointments - poisoning Skin Absorption - drug effects Spectrophotometry, Atomic Unithiol - administration & dosage Unithiol - therapeutic use |
| title | Urinary Mercury in Twelve Cases of Cutaneous Mercurous Chloride (Calomel) Exposure: Effect of Sodium 2,3-Dimercaptopropane-1-sulfonate (DMPS) Therapy |
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