The long-term retention of platinum in human tissues following the administration of cisplatin or carboplatin for cancer chemotherapy
Mass spectrometry has been used to study the distribution and retention of platinum in the tissues of patients following the administration of cisplatin or carboplatin. Blood platinum was measured up to 2 years and renal excretion up to 5 years after treatment. Platinum concentrations in plasma and...
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| Veröffentlicht in: | European journal of cancer (1990) 1992, Vol.28 (8), p.1358-1361 |
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| container_title | European journal of cancer (1990) |
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| creator | Tothill, Peter Klys, Howard S. Matheson, Lillian M. McKay, Keith Smyth, John F. |
| description | Mass spectrometry has been used to study the distribution and retention of platinum in the tissues of patients following the administration of cisplatin or carboplatin. Blood platinum was measured up to 2 years and renal excretion up to 5 years after treatment. Platinum concentrations in plasma and red cells fell according to a power function, approximately as the inverse square of the time after administration. The concentration in the urine fell more slowly. Necropsy samples were used to examine the distribution of platinum in various human organs up to 17 months after treatment. The highest concentrations were found in the liver, which retained approximately 2% of the dose. Although the results were scattered between patients, there was little loss of platinum after about 1 month. The prolonged retention of platinum may be relevant to long-term toxicity. |
| doi_str_mv | 10.1016/0959-8049(92)90519-8 |
| format | Article |
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Blood platinum was measured up to 2 years and renal excretion up to 5 years after treatment. Platinum concentrations in plasma and red cells fell according to a power function, approximately as the inverse square of the time after administration. The concentration in the urine fell more slowly. Necropsy samples were used to examine the distribution of platinum in various human organs up to 17 months after treatment. The highest concentrations were found in the liver, which retained approximately 2% of the dose. Although the results were scattered between patients, there was little loss of platinum after about 1 month. The prolonged retention of platinum may be relevant to long-term toxicity.</description><identifier>ISSN: 0959-8049</identifier><identifier>EISSN: 1879-0852</identifier><identifier>DOI: 10.1016/0959-8049(92)90519-8</identifier><identifier>PMID: 1515251</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Adolescent ; Adult ; Aged ; Carboplatin - metabolism ; Carboplatin - therapeutic use ; Carcinoma - drug therapy ; Carcinoma - metabolism ; Cisplatin - metabolism ; Cisplatin - therapeutic use ; Erythrocytes - chemistry ; Female ; Humans ; Liver - metabolism ; Male ; Middle Aged ; Osteosarcoma - drug therapy ; Osteosarcoma - metabolism ; Ovarian Neoplasms - drug therapy ; Ovarian Neoplasms - metabolism ; Platinum - metabolism ; Teratoma - drug therapy ; Teratoma - metabolism ; Testicular Neoplasms - drug therapy ; Testicular Neoplasms - metabolism ; Time Factors</subject><ispartof>European journal of cancer (1990), 1992, Vol.28 (8), p.1358-1361</ispartof><rights>1992</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c388t-c5f1cfe8f98e82ee2c2c4752bed46f867e347c1ddcee48a3aed72adaa49642173</citedby><cites>FETCH-LOGICAL-c388t-c5f1cfe8f98e82ee2c2c4752bed46f867e347c1ddcee48a3aed72adaa49642173</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0959-8049(92)90519-8$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,4024,27923,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1515251$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tothill, Peter</creatorcontrib><creatorcontrib>Klys, Howard S.</creatorcontrib><creatorcontrib>Matheson, Lillian M.</creatorcontrib><creatorcontrib>McKay, Keith</creatorcontrib><creatorcontrib>Smyth, John F.</creatorcontrib><title>The long-term retention of platinum in human tissues following the administration of cisplatin or carboplatin for cancer chemotherapy</title><title>European journal of cancer (1990)</title><addtitle>Eur J Cancer</addtitle><description>Mass spectrometry has been used to study the distribution and retention of platinum in the tissues of patients following the administration of cisplatin or carboplatin. Blood platinum was measured up to 2 years and renal excretion up to 5 years after treatment. Platinum concentrations in plasma and red cells fell according to a power function, approximately as the inverse square of the time after administration. The concentration in the urine fell more slowly. Necropsy samples were used to examine the distribution of platinum in various human organs up to 17 months after treatment. The highest concentrations were found in the liver, which retained approximately 2% of the dose. Although the results were scattered between patients, there was little loss of platinum after about 1 month. The prolonged retention of platinum may be relevant to long-term toxicity.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Carboplatin - metabolism</subject><subject>Carboplatin - therapeutic use</subject><subject>Carcinoma - drug therapy</subject><subject>Carcinoma - metabolism</subject><subject>Cisplatin - metabolism</subject><subject>Cisplatin - therapeutic use</subject><subject>Erythrocytes - chemistry</subject><subject>Female</subject><subject>Humans</subject><subject>Liver - metabolism</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Osteosarcoma - drug therapy</subject><subject>Osteosarcoma - metabolism</subject><subject>Ovarian Neoplasms - drug therapy</subject><subject>Ovarian Neoplasms - metabolism</subject><subject>Platinum - metabolism</subject><subject>Teratoma - drug therapy</subject><subject>Teratoma - metabolism</subject><subject>Testicular Neoplasms - drug therapy</subject><subject>Testicular Neoplasms - metabolism</subject><subject>Time Factors</subject><issn>0959-8049</issn><issn>1879-0852</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1992</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kM9O3DAQh62qFSzQN6CSTxUc0tpeJ7EvlRDiTyWkXuBsee0xa5TYi-2AeADeu16ypTdOo59mvhnNh9AxJT8ood1PIlvZCMLliWSnkrS0pk9oQUUvGyJa9hkt3kf20UHOD4SQXnCyh_ZoS1vW0gV6vV0DHmK4bwqkEScoEIqPAUeHN4MuPkwj9gGvp1EHXHzOE2Ts4jDEZx_ucam4tqMPPpek_5HG5xnGMWGj0yruonvLwUAtaxhjxZPevByhL04PGb7u6iG6u7y4Pb9ubv5c_T4_u2nMUojSmNZR40A4KUAwAGaY4X3LVmB550TXw5L3hlprALjQSw22Z9pqzWXHGe2Xh-j7vHeT4mN9pKjRZwPDoAPEKSvaMU4lI3WQz4MmxZwTOLVJftTpRVGitvbVVq3aqlWSqTf7SlTs227_tBrB_odm3bX_a-5DffLJQ1LZeKg6rE9girLRf3zgLzK2mGs</recordid><startdate>1992</startdate><enddate>1992</enddate><creator>Tothill, Peter</creator><creator>Klys, Howard S.</creator><creator>Matheson, Lillian M.</creator><creator>McKay, Keith</creator><creator>Smyth, John F.</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U7</scope><scope>C1K</scope></search><sort><creationdate>1992</creationdate><title>The long-term retention of platinum in human tissues following the administration of cisplatin or carboplatin for cancer chemotherapy</title><author>Tothill, Peter ; 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Blood platinum was measured up to 2 years and renal excretion up to 5 years after treatment. Platinum concentrations in plasma and red cells fell according to a power function, approximately as the inverse square of the time after administration. The concentration in the urine fell more slowly. Necropsy samples were used to examine the distribution of platinum in various human organs up to 17 months after treatment. The highest concentrations were found in the liver, which retained approximately 2% of the dose. Although the results were scattered between patients, there was little loss of platinum after about 1 month. The prolonged retention of platinum may be relevant to long-term toxicity.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>1515251</pmid><doi>10.1016/0959-8049(92)90519-8</doi><tpages>4</tpages></addata></record> |
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| identifier | ISSN: 0959-8049 |
| ispartof | European journal of cancer (1990), 1992, Vol.28 (8), p.1358-1361 |
| issn | 0959-8049 1879-0852 |
| language | eng |
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| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Adolescent Adult Aged Carboplatin - metabolism Carboplatin - therapeutic use Carcinoma - drug therapy Carcinoma - metabolism Cisplatin - metabolism Cisplatin - therapeutic use Erythrocytes - chemistry Female Humans Liver - metabolism Male Middle Aged Osteosarcoma - drug therapy Osteosarcoma - metabolism Ovarian Neoplasms - drug therapy Ovarian Neoplasms - metabolism Platinum - metabolism Teratoma - drug therapy Teratoma - metabolism Testicular Neoplasms - drug therapy Testicular Neoplasms - metabolism Time Factors |
| title | The long-term retention of platinum in human tissues following the administration of cisplatin or carboplatin for cancer chemotherapy |
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