The popliteal lymph node assay: results of a preliminary interlaboratory validation study

The popliteal lymph node (PLN) assay was proposed to predict possible autoimmune effects of xenobiotics. A preliminary interlaboratory validation study of the PLN assay was conducted in Wistar rats. Three laboratories tested in blind fashion four compounds, namely chlorpromazine, zimeldine, hydrazin...

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Veröffentlicht in:	Toxicology (Amsterdam) 1997-10, Vol.122 (3), p.213-218
Hauptverfasser:	Vial, T, Carleer, J, Legrain, B, Verdier, F, Descotes, J
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Bacterial Agents - toxicity Barbital - toxicity Biological and medical sciences Chlorpromazine - toxicity Drug-Related Side Effects and Adverse Reactions Experimental and animal immunopathology. Animal models GABA Modulators - toxicity General aspects. Methods Hindlimb Hydrazines - toxicity Immunoassay - methods Immunopathology Interlaboratory validation study Lymph Nodes - cytology Lymph Nodes - drug effects Lymph Nodes - immunology Male Medical sciences Popliteal lymph node assay Rats Rats, Wistar Reproducibility of Results Serotonin Uptake Inhibitors - toxicity Streptozocin - toxicity Toxicology Wistar rats Zimeldine - toxicity
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