Gadolinium-free T1 contrast agents for MRI: Tunable pharmacokinetics of a new class of manganese porphyrins

Purpose To evaluate a new class of manganese porphyrins with tunable pharmacokinetics as potential gadolinium (Gd)‐free T1 agents for contrast‐enhanced magnetic resonance imaging (MRI). Materials and Methods Two new contrast agents, MnTCP and MnP2, were evaluated in four female rats. MRI was perform...

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Veröffentlicht in:	Journal of magnetic resonance imaging 2014-12, Vol.40 (6), p.1474-1480
Hauptverfasser:	Cheng, Hai-Ling Margaret, Haedicke, Inga E., Cheng, Weiran, Tchouala Nofiele, Joris, Zhang, Xiao-an
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals cardiovascular imaging Contrast Media - pharmacokinetics dynamic contrast-enhanced (DCE) MRI Female liver imaging Magnesium Compounds - pharmacokinetics Magnetic resonance imaging Magnetic Resonance Imaging - methods Metabolic Clearance Rate Organ Specificity - physiology permeability imaging pharmacokinetics Porphyrins - pharmacokinetics positive contrast MRI contrast agents Rats Rats, Long-Evans Tissue Distribution Whole Body Imaging - methods
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